Difference between revisions of "LINC00174"
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| − | <ref name="ref1">Shen Y, Gao X, Tan W, Xu T. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ | + | <ref name="ref1">Shen Y, Gao X, Tan W, Xu T. STAT1-mediated upregulation of lncRNA LINC00174 functions a ceRNA for miR-1910-3p to facilitate colorectal carcinoma progression through regulation of TAZ. Gene. 2018, 666:64-71. |
</ref>(1)</references> | </ref>(1)</references> | ||
Revision as of 05:56, 18 December 2018
Overexpression of LINC00174 in colorectal cancer (CRC) tissues and cells correlates with poor prognosis and might be critical to CRC progression.
Contents
Annotated Information
Name
LINC00174: long intergenic non-protein coding RNA 174 (HGNC nomenclature).
Characteristics
Long intergenic non-protein coding RNA 174 (LINC00174) (NR_026873.1), is located on chromosome 7q11.21 and has a transcript length of 4426 nucleotides [1].
Function
LINC00174 contributes to CRC progression by regulating miR-1910-3p/TAZ signal pathway. Oncogenic role of LINC00174 in clinical specimens and cellular experiments has been identified, showing the potential LINC00174/miR-1910-3p/TAZ pathway [1].
Diseases
- Colorectal cancer (CRC) [1]
Expression
Increased expression of LINC00174 has been observed in CRC tissues and cells in comparison to their corresponding controls [1]. Also, the aberrant overexpression of LINC00174 indicated the poor prognosis of CRC patients [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| qRT-PCR | 5'-GGCCCAACACTTCCCTCAAA- 3' | 5'-CAGGGAGAAACGACCTGGAG- 3'[1] |
Labs working on this lncRNA
- Department of Geratology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. [1]
- Department of Endocrinology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. [1]
- Department of Gastroenterology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. [1]
- Department of Endocrinology, Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. [1]
References
Sequence
>gi|285908|ref|NR_026873.1| Homo sapiens long intergenic non-protein coding RNA 174 (LINC00174), long non-coding RNA
000001 GTGGTTTGAT CTTGGCTCAC TGCAGTCTCA ACCTCTCAGG CTCAAGCTAT CCTTCTGCCT CAGACTCTGG GGTAGCTGGG 000080
000081 ACAACAGCCT CAGCCAAGAT GTCTCACCCT ACTCTCTATG ATGCAACAAG AAGCCCCTGG GGAATGTTTC AGTCCCAGTC 000160
000161 TGTACTATTG TCATGTGCTC ATCACAGTCT GGTGGAATTT AAATGACCTT TTATCAAGAT GGATAAACGC AAGTTTCCCA 000240
000241 GTGCTGGAAT ACAGAAAATG GATGGACAAA CAGGGTCTTG CTCTGTTGTC CAGGCTGGAG TGCGGTAGTG CTATCACAGC 000320
000321 TGACTGCATC CTCAACCTCT CAGGCTCAAG CAGTCCTCCC ACCTCAGCCT CCCAGGTGGC TGAGACTGTA CGTGCTTGCC 000400
000401 ACAATGCCCA ACTAATAATT TGGACTTTTC CTATACATGG GTTCCAAAGG GCTGACTGCG AAACGAAGTG ACCTCACAAT 000480
000481 GACTCAAGCT ACCACTTAGT GTTGATTGTG ATGAAATGCC AGCTGTGGCA TATGCCTTGG GAGCTAAGTG GCTGCTGCAC 000560
000561 TTGACCACTA TGAAGACTGG TGTGGAAGGG TCCTTCTGGA TGTACTTGGG CAGGGTCCCC AACGCCAGAG CCATGGAACT 000640
000641 GTAAGGAGCC ACACAGCCGG AGGTGAATGG TGTTGAATGA GGGAAGCTTC ATCTGTGTTT ACAGCCACTC CCCATTGCTC 000720
000721 ACATTCCTGC CTGAGCTCTG CCTTCTCTCA GATCAGCAGC AGCATTAGAT TCTCATAGGA GCATGCACCC CATTGTGAAC 000800
000801 CATGCATGTG AGGGATCTAC GTTGCGCTGT CCCTATGAGA ATCTAATGCC TGATGCTCTG TCACTTTCTC CAATATTATC 000880
000881 TTCAAGTGAG CCACTCCTGG CCCAATTCCT GTCTCCCGTT GGCCTATAGA GGCCAAGCCT CTGCCTCATG ATGGCCTCTG 000960
000961 CAGGTCAAGC TCCTCCTCCT GGTTCCGTCT ACAGGCCCAA CACTTCCCTC AAATAAACTC TTCTGCCCAG CTCCTGTCCA 001040
001041 GCTCACGGCA GCCACTGTCG GCATGAAAAT TCCTCAATTC AAGCTCTCTA GGCCCACCTT CTGCCTCCCA CTGGCCTGGA 001120
001121 CACGCCCAGC TCCAACCTGA CAATGGTCTC TACAGGCCCA GCTCATCGGG CTCTGAGGGA CCTCTCCAGG CCAAGCTCTT 001200
001201 ACCTCACGGA GGCTTCTCCA GGTCGTTTCT CCCTGTCTTC AGGCAGTGGT GACAGGTCAG CTCCTCCTCC ACAGTGGCCT 001280
001281 CGTTTGGGCA GGTCCTGCCT CTTGCAGCCT CTCAAAGCCC AGCTCCTGCC TCTGAGTGGC TTCTGCGCAC CCAAATGTCC 001360
001361 TCCAGTCAGC CTGTCCTGGC TGAGCTCCTG CGACCTGGCT GAGCTCCTGC CTCCTGTCGG CCTCTATAAA CCCAGCCTCT 001440
001441 GCTGTATGGT GGCTTCTTCA GGCCCAGCTC TTCCTCCTGG CGGTGTATAC AGGTCCAACT CCTGCTTCCC AATGGACTCT 001520
001521 TTAGGCCAGG CTCATGCCTT ACGGCAGCCT TTCCTGGCCC AGCTTTTGCC TGTTGGCATA CCCTCCAGGC CCACAATGTA 001600
001601 CTCAGATCAG CCACTCCATT CCCAGCTCTT CTTCCTGGCT GTGTCTACAG GCCCAACTGC TGCCTCACAA CACCCTCTTT 001680
001681 TGGCCCAGCT CCTGCCCAGC ACCTGGTGGC CTCTATATGC CCCAGACTTC TTAAAGTCAA CTTTGCTAGG CCCACCTTTG 001760
001761 GCCTCCCAGC GGCTTTGACA GGACCAGCTC TTGCCTCATG GCAGCTTCCC AACGCCAGGT TTCTGCCTGC ATTGTGGCAT 001840
001841 CCTTGATGGA CCCAACTCTT GCTTTATGCC GGCCTTCCCA CACCAAGTTT CTGCCTGCCT CATGGCAGGA TCCGATAGGC 001920
001921 CCAGCTCCTG CCTCTAATGG CCTGGTTAGG CTCATCTCAT CCCTCAAGGT GGCCACCCCA GATGAAGCTC CTGCCTTTTG 002000
002001 GCAGCCTTTA GAGGCCCAGC TCATGCATCT CATTGCCTCT TGAAGCCCAG CTCATTCCTC AAAACGGCCT ATCCACGCCC 002080
002081 AGCTTTTCCC TTTGGTGGCT TCTCCAGGCC CAGAAATTCC TCAGTTCGGC TTCGCAAGGT GAAGTTGCTG CCTCCCTGTG 002160
002161 CCTTCTCCAG GCCCAGTTCT TCCTCCCAGC TGGGTCTACA GTCCCATCTC CTGACTCAAA ACAACCTATT TTGGCTCGGC 002240
002241 TCCTGCCCAG CACCTGGCGG CCTTTGTAGG CCTAAAGCTT CCTCAAGTCA AGCGTTCCAG GCCCAGATCA TGCTGCCCAG 002320
002321 GGGCCTTCAC AGGCCCAGCT ACTGCCTGAC GATGGCTTCC CCAGGCCCAG GTCTTGCCTT CCCCCAGCCT CCCGAGGCCC 002400
002401 AGCCCTTGCC TCACAGTTGC TTTCCCAGTC CACGTTACAG CCTGTTACCC GACGGCCTTG ACAGACCAAA CTCTTCCTTC 002480
002481 ACACTGGACA GTTTAGGACA AGCTCATACG TCTTCCAGCC TCTCCAGGTC AAGCTCCTGC CTCACACTGG CCTCTATAGG 002560
002561 CCCAGGTGCT GAATCGCAAT GGTCTGTTTA GGTCCATCTC ATGCCTTTCT CAGACTCTCC AAGCGACGAT CTGGCCTGAC 002640
002641 ACTTGCTTCT GTGGGCCATG TGATCACTCA CACTGGCCTC TTTAGGATCA GGGGATGCCT CTCCACAGGC CGAGATCCTG 002720
002721 CCTGTTGTAG GCCCCTTCAG GATGCGCCGC TGCCTGACAG TGGACCCTCC AGGCCTAGAT GTTACGTGAT CATGGCCTCT 002800
002801 GCAGGTCAAG AATTTAAATT TTCGCAGCCT CTATAGGCCA GGCTACTGCC TCCTGATAAT GGCTTCTGCA GGCCCAAATC 002880
002881 GTCCTGAAAT AAGCCTCGCC AGGAACAGCA CGTGTGTTGG ATGCCCGAAC AACCATAGCT TCTCCCGCAC AGTGGCCCAT 002960
002961 GGGGGCCGGG CTCTTGCCTC AGCCTGGCCA CCTCAGGCCC AGTTCTTGCC TGTTGGCGGC CGCTCCAGGC CCGGCTCCTG 003040
003041 CCCCTCGGCC TCCTCTCCAG GCCCAGAACT GGTTCCCGTC GGCCTCTCCA GGCCCAGCTC TCCCGGCCAC CTCCACGGGC 003120
003121 CCAGCTCCTG CCTCACGACA ACCACGTTCG GCCCAGCTCC TGCCCAGCTC CTGGCAGCCG TTGTAGGCCC CAGGCTTCCC 003200
003201 TGCGTTCAGG CCTCCCGGAC CCACCTTCGG CTTTCCGGCG GCCCTGAGAG ACCCGGCTCC TGCCTGCCAG CGGCCTCTCC 003280
003281 CGGCCCAGCT GCGGCCTCAC GTCGGCCTCC CCAGGCCACG TTTCCGCCTG CCTCACGGCA GCCCCGGCAG GCCCGGCTCC 003360
003361 CGCCTGCCGG GGGCCTCTTG AGGAGGCTCA TCTCGTGCCC GGCCGCGGCC TCCCCAGGCC AGGCTCCTGC CTGCCGGCAG 003440
003441 GCGCCACAAG CCCAGCTCCT GCGTCCCGAA GGCTTCTCTA GGCCCGGCTC GTGCCTCGCT GCGGCCTCTT GAGGCCCAGC 003520
003521 TTTTCCCTTG TGGTGGCCTC TCCAGGCCCA GAACTTCCTC AAGTCGGCCT CCCCCGGTCC AGTGGCTGCC TCCCGGCCTC 003600
003601 CTCTCCGGGC CCAGCTCTTT GCTCGCGTCT GCGCCCGTGG GCCCAGCTCC CGTCTCCAAA CAGCCTCCTT CGACTCGGCT 003680
003681 CCTGCCCAGC TCCCGGCGGC CTTCGTAGGC CCGAAGCCTC CTCCAGTCCA GCTCTCCAGG GCCGCGTCTT GCCTCGCCTC 003760
003761 GCCTCCCCTC ACCTTGCCTC ACCTCGCAGC AGCCTTTCCA GGCCCAGCTC CCGCCTCCCG GCGGCCTTCC CCTGCCACGC 003840
003841 TCGTGCCGGC CTCCCGGCAG CCTCCACCAG CCCGGCTCCT GCCTCACGCT GGCCCCTCTG GGCCCAGCTC ATGCCTCGCG 003920
003921 GTGGCCTCTC CGGGCCCAGC TCCCACCCAG CCTGACGGCG CCTCCCGGCC CCAAGCTGCC TTCCTCGATG TGGCCCAAAG 004000
004001 TGGCCCAAAG CGTCCCAAAG TAGGCCTCGC CAGGCCCACC TCCTGCCCGG CGTAGGCCCT GAGGGGCGCG GCCCCTGCCC 004080
004081 CATACTGGCC TCTTTTGGGC CCTCTCTTAC ACCAGCCCCT GTCTCAGGAT TGTCTCTTCA CGCCCATCTT CTGCCTCATA 004160
004161 GTGGTCACTC AAGGCCTCGC TTTTGCCTGA TGATTGCGTT TTCTGGTTTT GCTCTTGCCT TGTATTCCCT TCTTCGGGAT 004240
004241 ACAGCTTTTA CGTCTTCCAT GGTGAACCTC ATCAAGGAGA CTAAATCTTC CCTGGTCTGT CATTTTTTTC ACTTCACACC 004320
004321 AGAGTGCCTT GGGAAAACCC CATCTCTTCT TTTAACCTTG AGAGTGGATT TCTGACGAAT TGATAATAAA TTTTTTCTCT 004400
004401 GTGGTTTCAG TGATTTCTGT TTTAAA
000081 ACAACAGCCT CAGCCAAGAT GTCTCACCCT ACTCTCTATG ATGCAACAAG AAGCCCCTGG GGAATGTTTC AGTCCCAGTC 000160
000161 TGTACTATTG TCATGTGCTC ATCACAGTCT GGTGGAATTT AAATGACCTT TTATCAAGAT GGATAAACGC AAGTTTCCCA 000240
000241 GTGCTGGAAT ACAGAAAATG GATGGACAAA CAGGGTCTTG CTCTGTTGTC CAGGCTGGAG TGCGGTAGTG CTATCACAGC 000320
000321 TGACTGCATC CTCAACCTCT CAGGCTCAAG CAGTCCTCCC ACCTCAGCCT CCCAGGTGGC TGAGACTGTA CGTGCTTGCC 000400
000401 ACAATGCCCA ACTAATAATT TGGACTTTTC CTATACATGG GTTCCAAAGG GCTGACTGCG AAACGAAGTG ACCTCACAAT 000480
000481 GACTCAAGCT ACCACTTAGT GTTGATTGTG ATGAAATGCC AGCTGTGGCA TATGCCTTGG GAGCTAAGTG GCTGCTGCAC 000560
000561 TTGACCACTA TGAAGACTGG TGTGGAAGGG TCCTTCTGGA TGTACTTGGG CAGGGTCCCC AACGCCAGAG CCATGGAACT 000640
000641 GTAAGGAGCC ACACAGCCGG AGGTGAATGG TGTTGAATGA GGGAAGCTTC ATCTGTGTTT ACAGCCACTC CCCATTGCTC 000720
000721 ACATTCCTGC CTGAGCTCTG CCTTCTCTCA GATCAGCAGC AGCATTAGAT TCTCATAGGA GCATGCACCC CATTGTGAAC 000800
000801 CATGCATGTG AGGGATCTAC GTTGCGCTGT CCCTATGAGA ATCTAATGCC TGATGCTCTG TCACTTTCTC CAATATTATC 000880
000881 TTCAAGTGAG CCACTCCTGG CCCAATTCCT GTCTCCCGTT GGCCTATAGA GGCCAAGCCT CTGCCTCATG ATGGCCTCTG 000960
000961 CAGGTCAAGC TCCTCCTCCT GGTTCCGTCT ACAGGCCCAA CACTTCCCTC AAATAAACTC TTCTGCCCAG CTCCTGTCCA 001040
001041 GCTCACGGCA GCCACTGTCG GCATGAAAAT TCCTCAATTC AAGCTCTCTA GGCCCACCTT CTGCCTCCCA CTGGCCTGGA 001120
001121 CACGCCCAGC TCCAACCTGA CAATGGTCTC TACAGGCCCA GCTCATCGGG CTCTGAGGGA CCTCTCCAGG CCAAGCTCTT 001200
001201 ACCTCACGGA GGCTTCTCCA GGTCGTTTCT CCCTGTCTTC AGGCAGTGGT GACAGGTCAG CTCCTCCTCC ACAGTGGCCT 001280
001281 CGTTTGGGCA GGTCCTGCCT CTTGCAGCCT CTCAAAGCCC AGCTCCTGCC TCTGAGTGGC TTCTGCGCAC CCAAATGTCC 001360
001361 TCCAGTCAGC CTGTCCTGGC TGAGCTCCTG CGACCTGGCT GAGCTCCTGC CTCCTGTCGG CCTCTATAAA CCCAGCCTCT 001440
001441 GCTGTATGGT GGCTTCTTCA GGCCCAGCTC TTCCTCCTGG CGGTGTATAC AGGTCCAACT CCTGCTTCCC AATGGACTCT 001520
001521 TTAGGCCAGG CTCATGCCTT ACGGCAGCCT TTCCTGGCCC AGCTTTTGCC TGTTGGCATA CCCTCCAGGC CCACAATGTA 001600
001601 CTCAGATCAG CCACTCCATT CCCAGCTCTT CTTCCTGGCT GTGTCTACAG GCCCAACTGC TGCCTCACAA CACCCTCTTT 001680
001681 TGGCCCAGCT CCTGCCCAGC ACCTGGTGGC CTCTATATGC CCCAGACTTC TTAAAGTCAA CTTTGCTAGG CCCACCTTTG 001760
001761 GCCTCCCAGC GGCTTTGACA GGACCAGCTC TTGCCTCATG GCAGCTTCCC AACGCCAGGT TTCTGCCTGC ATTGTGGCAT 001840
001841 CCTTGATGGA CCCAACTCTT GCTTTATGCC GGCCTTCCCA CACCAAGTTT CTGCCTGCCT CATGGCAGGA TCCGATAGGC 001920
001921 CCAGCTCCTG CCTCTAATGG CCTGGTTAGG CTCATCTCAT CCCTCAAGGT GGCCACCCCA GATGAAGCTC CTGCCTTTTG 002000
002001 GCAGCCTTTA GAGGCCCAGC TCATGCATCT CATTGCCTCT TGAAGCCCAG CTCATTCCTC AAAACGGCCT ATCCACGCCC 002080
002081 AGCTTTTCCC TTTGGTGGCT TCTCCAGGCC CAGAAATTCC TCAGTTCGGC TTCGCAAGGT GAAGTTGCTG CCTCCCTGTG 002160
002161 CCTTCTCCAG GCCCAGTTCT TCCTCCCAGC TGGGTCTACA GTCCCATCTC CTGACTCAAA ACAACCTATT TTGGCTCGGC 002240
002241 TCCTGCCCAG CACCTGGCGG CCTTTGTAGG CCTAAAGCTT CCTCAAGTCA AGCGTTCCAG GCCCAGATCA TGCTGCCCAG 002320
002321 GGGCCTTCAC AGGCCCAGCT ACTGCCTGAC GATGGCTTCC CCAGGCCCAG GTCTTGCCTT CCCCCAGCCT CCCGAGGCCC 002400
002401 AGCCCTTGCC TCACAGTTGC TTTCCCAGTC CACGTTACAG CCTGTTACCC GACGGCCTTG ACAGACCAAA CTCTTCCTTC 002480
002481 ACACTGGACA GTTTAGGACA AGCTCATACG TCTTCCAGCC TCTCCAGGTC AAGCTCCTGC CTCACACTGG CCTCTATAGG 002560
002561 CCCAGGTGCT GAATCGCAAT GGTCTGTTTA GGTCCATCTC ATGCCTTTCT CAGACTCTCC AAGCGACGAT CTGGCCTGAC 002640
002641 ACTTGCTTCT GTGGGCCATG TGATCACTCA CACTGGCCTC TTTAGGATCA GGGGATGCCT CTCCACAGGC CGAGATCCTG 002720
002721 CCTGTTGTAG GCCCCTTCAG GATGCGCCGC TGCCTGACAG TGGACCCTCC AGGCCTAGAT GTTACGTGAT CATGGCCTCT 002800
002801 GCAGGTCAAG AATTTAAATT TTCGCAGCCT CTATAGGCCA GGCTACTGCC TCCTGATAAT GGCTTCTGCA GGCCCAAATC 002880
002881 GTCCTGAAAT AAGCCTCGCC AGGAACAGCA CGTGTGTTGG ATGCCCGAAC AACCATAGCT TCTCCCGCAC AGTGGCCCAT 002960
002961 GGGGGCCGGG CTCTTGCCTC AGCCTGGCCA CCTCAGGCCC AGTTCTTGCC TGTTGGCGGC CGCTCCAGGC CCGGCTCCTG 003040
003041 CCCCTCGGCC TCCTCTCCAG GCCCAGAACT GGTTCCCGTC GGCCTCTCCA GGCCCAGCTC TCCCGGCCAC CTCCACGGGC 003120
003121 CCAGCTCCTG CCTCACGACA ACCACGTTCG GCCCAGCTCC TGCCCAGCTC CTGGCAGCCG TTGTAGGCCC CAGGCTTCCC 003200
003201 TGCGTTCAGG CCTCCCGGAC CCACCTTCGG CTTTCCGGCG GCCCTGAGAG ACCCGGCTCC TGCCTGCCAG CGGCCTCTCC 003280
003281 CGGCCCAGCT GCGGCCTCAC GTCGGCCTCC CCAGGCCACG TTTCCGCCTG CCTCACGGCA GCCCCGGCAG GCCCGGCTCC 003360
003361 CGCCTGCCGG GGGCCTCTTG AGGAGGCTCA TCTCGTGCCC GGCCGCGGCC TCCCCAGGCC AGGCTCCTGC CTGCCGGCAG 003440
003441 GCGCCACAAG CCCAGCTCCT GCGTCCCGAA GGCTTCTCTA GGCCCGGCTC GTGCCTCGCT GCGGCCTCTT GAGGCCCAGC 003520
003521 TTTTCCCTTG TGGTGGCCTC TCCAGGCCCA GAACTTCCTC AAGTCGGCCT CCCCCGGTCC AGTGGCTGCC TCCCGGCCTC 003600
003601 CTCTCCGGGC CCAGCTCTTT GCTCGCGTCT GCGCCCGTGG GCCCAGCTCC CGTCTCCAAA CAGCCTCCTT CGACTCGGCT 003680
003681 CCTGCCCAGC TCCCGGCGGC CTTCGTAGGC CCGAAGCCTC CTCCAGTCCA GCTCTCCAGG GCCGCGTCTT GCCTCGCCTC 003760
003761 GCCTCCCCTC ACCTTGCCTC ACCTCGCAGC AGCCTTTCCA GGCCCAGCTC CCGCCTCCCG GCGGCCTTCC CCTGCCACGC 003840
003841 TCGTGCCGGC CTCCCGGCAG CCTCCACCAG CCCGGCTCCT GCCTCACGCT GGCCCCTCTG GGCCCAGCTC ATGCCTCGCG 003920
003921 GTGGCCTCTC CGGGCCCAGC TCCCACCCAG CCTGACGGCG CCTCCCGGCC CCAAGCTGCC TTCCTCGATG TGGCCCAAAG 004000
004001 TGGCCCAAAG CGTCCCAAAG TAGGCCTCGC CAGGCCCACC TCCTGCCCGG CGTAGGCCCT GAGGGGCGCG GCCCCTGCCC 004080
004081 CATACTGGCC TCTTTTGGGC CCTCTCTTAC ACCAGCCCCT GTCTCAGGAT TGTCTCTTCA CGCCCATCTT CTGCCTCATA 004160
004161 GTGGTCACTC AAGGCCTCGC TTTTGCCTGA TGATTGCGTT TTCTGGTTTT GCTCTTGCCT TGTATTCCCT TCTTCGGGAT 004240
004241 ACAGCTTTTA CGTCTTCCAT GGTGAACCTC ATCAAGGAGA CTAAATCTTC CCTGGTCTGT CATTTTTTTC ACTTCACACC 004320
004321 AGAGTGCCTT GGGAAAACCC CATCTCTTCT TTTAACCTTG AGAGTGGATT TCTGACGAAT TGATAATAAA TTTTTTCTCT 004400
004401 GTGGTTTCAG TGATTTCTGT TTTAAA
