Difference between revisions of "ZNF451-AS1"
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| − | ''ZNF451-AS1'' is a long non-coding RNA that suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451. | + | ''ZNF451-AS1'', is a long non-coding RNA that suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451. |
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''ZNF451-AS1'' suppresses tumor growth in a xenograft model of pancreatic ductal adenocarcinoma (PDAC) by inhibiting zinc finger protein 451 (ZNF451) expression <ref name="ref1" />. | ''ZNF451-AS1'' suppresses tumor growth in a xenograft model of pancreatic ductal adenocarcinoma (PDAC) by inhibiting zinc finger protein 451 (ZNF451) expression <ref name="ref1" />. | ||
| − | + | ZNF451 expression inversely correlated with the ''ZNF451-AS1'' levels in the pancreatic ductal adenocarcinoma (PDAC) tumor tissues and cell lines. ''ZNF451-AS1'' over-expression led to decreased the levels of ZNF451 expression in the pancreatic cancer cells and enhanced the level of p15 and p21 expression, and suppressed the proliferation and migration of the AsPC-1 and PANC-1 cells, ultimately lead to growth arrest in pancreatic cancer cells <ref name="ref1" />. | |
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===Expression=== | ===Expression=== | ||
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| | 5'-ACTTGCTGGGAGTGTTGGT- 3'<ref name="ref1" /> | | | 5'-ACTTGCTGGGAGTGTTGGT- 3'<ref name="ref1" /> | ||
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===Regulation=== | ===Regulation=== | ||
Revision as of 06:30, 26 December 2018
ZNF451-AS1, is a long non-coding RNA that suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451.
Contents
Annotated Information
Name
ZNF451-AS1: ZNF451 regulatory antisense RNA 1 (HGNC nomenclature) BC032020 [1].
Characteristics
ZNF451-AS1 is four exon transcript consisting of 690 bp and located on human chromosome chr6p12.1 [1].
Function
ZNF451-AS1 suppresses tumor growth in a xenograft model of pancreatic ductal adenocarcinoma (PDAC) by inhibiting zinc finger protein 451 (ZNF451) expression [1].
ZNF451 expression inversely correlated with the ZNF451-AS1 levels in the pancreatic ductal adenocarcinoma (PDAC) tumor tissues and cell lines. ZNF451-AS1 over-expression led to decreased the levels of ZNF451 expression in the pancreatic cancer cells and enhanced the level of p15 and p21 expression, and suppressed the proliferation and migration of the AsPC-1 and PANC-1 cells, ultimately lead to growth arrest in pancreatic cancer cells [1].
Expression
ZNF451-AS1 levels in the pancreatic ductal adenocarcinoma (PDAC) tumor tissues were lower than those in the adjacent normal tissues [1].
| Experiment | Forward primer | Reverse primer |
|---|---|---|
| RT-qPCR | 5'-CACTGAAGCCTCAACCTCC- 3' | 5'-ACTTGCTGGGAGTGTTGGT- 3'[1] |
Regulation
please input information here
Diseases
- Pancreatic ductal adenocarcinoma (PDAC) [1]
Labs working on this lncRNA
- Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China [1]
References
Sequence
>gi|101927211|ref|NR_110742.1| Homo sapiens ZNF451 regulatory antisense RNA 1 (ZNF451-AS1), long non-coding RNA
000081 ATTCAAAGCA AGAACAACGA CATTATGGGG AGAAAACGTC CTTTTGTGAA ACAGAAGGCA ATCCACACCA TTAGTAAACC 000160
000161 CCATCAATTT TGCCTTCAGA ATATATCCAG ATTCTTCCCA ATTCTACCGC CACCATTCTG GTTCAAGCTA CCTGGTAAAA 000240
000241 CATGCACAGA GCAAATTTCG GTTGTATCCT AGAAATGATA GCCATATTGA GGATACTGGT TACACCTGAC GAAACATCTC 000320
000321 CATGAAAGTT AAGCATACAC AGGATCTCAC TTTGTTACCC AGGCTAGAGT GCAATGGTGT GACCACAGCT CACTGAAGCC 000400
000401 TCAACCTCCT GAGCTCACTT TTAAGCAATC CTCTCACTTC GGCCTCCTGA GTAGCTGGGC CTACAGGCAT GTACCAACAC 000480
000481 TCCCAGCAAG TTTTTCTTAT TTTTGTGAAG ACAGAGTCTT GCAGTATTGC CCAAGCTGGA CTTGAACTCC TGGCCTCAAG 000560
000561 CAATCCTCCC ATCTAGGCCT CCCAAAGTGC TAGGATTACA GGCATGAGCC ACTGTGCCAA GCAACACTTG CAGTTTTTAA 000640
000641 GTGAAAATGA TCCTGTAAAT ATATATATGA ATAAAATCTA GAAAGCTATA
