NONHSAT107640
Revision as of 11:54, 6 October 2014 by 111.204.253.116 (talk)
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Contents
Annotated Information
Transcriptomic Nomeclature
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Function
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Regulation
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Expression
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Allelic Information and Variation
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Evolution
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Labs working on this lncRNA
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References
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Basic Information
Transcript ID |
NONHSAT107640 |
Source |
NONCODE4.0 |
Same with |
, |
Classification |
intergenic |
Length |
500 nt |
Genomic location |
chr6+:8652442..8654459 |
Exon number |
3 |
Exons |
8652442..8652623,8653778..8654079,8654444..8654459 |
Genome context |
|
Sequence |
000001 ATGGGGGTGG AACTCATGAT GGAATTGGAG CCTTTACAAG GGAATGAAGA GACAAGAGCT CTCTTTATGC CACGTGAGGA 000080
000081 TACAGCAAGG CCCCAATCTG CAAGCCAGGA AGAGTCGTCA CGAGAACCAG ACCATGCAGG AACTCTGATC GTGGACATTT 000160 000161 CAACCTCCAG AACTGTGATC CAAAATGCAT ATGTATCTTT GGAAGAAACT CTGAAGTAAA GGCCGGAATA TTCTTTGTTT 000240 000241 AAAACATTAA AAACAAAACA GACCAAAGCA TCAAGCAAGA AGTTTCCTGG CAATAAACTA AGCACAGCAT TATTTTTTAA 000320 000321 GGAACACAAA TTAAGTGTTC AACCTGTGGC AAATTTGTAC TTTCTCCCTG AATTATGTTG TTATCAAAGA AAAAAATTGG 000400 000401 GAAGCATGGC AAAATATCAT CAAAACTGAA ACTAGAATTA AACAAAACTA AATTAAAATG AAATAAAATG ATGTCCATTC 000480 000481 TTAAAAAAAA AAAAAAAAAA |
Annotation (From lncRNAdb)
Section | Description |
---|---|
ID | HULC |
Characteristics | ~500nuc, spliced, polyadenylated, two exon transcript (Panzitt (2007)). Exon 1 mainly consists of an LTR (MLT1A) (Panzitt (2007)). |
Expression | Binding of phospho-CREB to the HULC promoter activates HULC expression. Phosphorylation of CREB was stimulated by PKA signaling (Wang (2010)). Highly up-regulated in hepatocellular carcinoma (HCC) and to a lesser extent in liver focal nodular hyperplasia (FNH). Up-regulation was specific to HCC with high expression not detected in normal liver, other tissues and their associated neoplasms (Panzitt (2007)). HULC expression was also up-regulated in colorectal carcinomas that metastasised to the liver but not in primary colorectal carcinomas or carcinomas that metastasised to lymph nodes (Matouk (2009)). HULC RNA could be detected in the blood of HCC patients (Panzitt (2007)). Localised to the cytoplasm, may associate with ribosomes, but no sign of translated products could be found (Panzitt (2007)). HULC expression was also identified in 3 old world monkeys (Panzitt (2007)). |
Function | Competing endogenous RNA (ceRNA). Functions as a sponge/ target mimic for miR-372 through a conserved target site, reducing the expression and activity of miR-372 (Wang (2010)). One of targets of miR-372 is Prkacb (catalytic subunit of PKA) which is able to phophorylate CREB. Hence expression of HULC stimulates further HULC expression by inhibiting miR-372, and allowing PRKACB to create active CREB (Wang (2010)). HULC knockdown affects expression of other genes including some described in liver cancer (Panzitt (2007)). |
Conservation | HLUC also present in other primates, gene shows good conservation above that of surrounding sequence. Not detected in rodents so may be primate specific (Panzitt (2007)). |
Name | HULC: Highly upregulated in liver cancer RNA |