LINC00458
LncRNA ES3 was significantly upregulated in HER2-positive breast tumors and may contribute to breast cancer proliferation as a downstream target of HER2. [1].
Contents
Annotated Information
Name
Approved symbol:LINC00458
Approved name:long intergenic non-protein coding RNA 458
HGNC ID HGNC:42807
Alias symbol:LncRNA-ES3|ES3
RefSeq ID:NR_108062
LncBook ID:https://bigd.big.ac.cn/lncbook/gene?geneid=HSALNG0097328
Characteristics
The long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide.The peptide mainly interacts with the RNA-binding proteins, including the m6A reader IGF2BP1, and is thus named "RNA-binding regulatory peptide" (RBRP). [2].
Function
LINC00458 has diagnostic value in breast cancer diagnosis. [1].
Regulation
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Expression
ES3 upregulation in breast cancer .[1] ES3 expression downregulated during neural differentiation.[1]
Diseases
Breast cancer.[1]
Labs working on this lncRNA
- Stem Cell and Developmental Biology Group, Genome Institute of Singapore, Singapore.[2]
- Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Keshavarz M, Asadi MH, Riahi-Madvar A. Upregulation of pluripotent long noncoding RNA ES3 in HER2-positive breast cancer. J Cell Biochem. 2019 Oct;120(10):18398-18405. doi: 10.1002/jcb.29152. Epub 2019 Jun 18. PMID: 31211468.
- ↑ 2.0 2.1 Ng SY, Johnson R, Stanton LW. Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors. EMBO J. 2012 Feb 1;31(3):522-33. doi: 10.1038/emboj.2011.459. Epub 2011 Dec 23. PMID: 22193719; PMCID: PMC3273385.
