ENST00000501122.2
This is the long isoform of Neat1.
Contents
Annotated Information
Name
Neat1: Nuclear enriched abundant transcript 1, also known as Men (multiple endocrine neoplasia) ɛ/β orVINC (virus-inducible ncRNA).
This is the long isoform of Neat1, which is named as Neat1 v2 or Neat1_2. The short isoform is named as Neat1 v1 or Neat1_1.
Multiple endocrine neoplasia 1 (MEN1).
Long isoform - MEN beta.
VINC: Virus-inducible ncRNA
Disease
cancer
Characteristics
Processing of two isoforms of NEAT1. NEAT1 has two isoforms. [[1]]
Neat1 is broadly expressed and highly abundant lncRNA in mammalian cell nuclei and have two isoforms[1]: ~3.7 (NEAT1 v1/ MEN epsilon) and ~23 kb (NEAT1 v2/ MEN beta) transcribed from the MEN1 locus[2][3][4][5].
Single exon transcript,long isoform is a continuation of the short isoform[4].
These two isoforms share the same transcriptional start site, but their 3′ ends are processed by distinct mechanisms: canonical polyadenylation or RNase P cleavage.Intergenic[6].
The two Neat1 isoforms also have differing stability, with the long (v2/Men beta) isoform more stable than than the shorter (v1/Men epsilon) isoform in N2A and 3T3 cells[7]. NEAT1 was exclusively localized in the nuclei of the villous trophoblasts and was expressed in more nuclei and with greater intensity in IUGR placentas than in CTRLs. PSPC1, one of the three main proteins of the paraspeckle, co-localized with NEAT1 in the villous trophoblasts. The expression of NEAT1_2 mRNA, the long isoform of NEAT1, was only modestly increased in IUGR vs. CTRL placentas[8].
A conserved tRNA like sequence at the 3' end is cleaved off and processed to generate a short tRNA-like ncRNA from the long (Men beta) transcript, similar to Malat1[5]. The last ~500bp of the short (Men epsilon) isoform has been shown to be expressed in trophoblast cells with a function potentially independent from the Neat1 transcript.
NEAT1_2 is non-polyadenylated[1].
NEAT1_2 is processed by RNase P with a similar mechanism to that of MALAT1 ,RNase P cleavage leads to the formation of a mature 3′ end of NEAT1_2 , which is protected by a triple helical structure[1].
Function
Transcription of Neat1 is essential for the assembly, maintenance and structural integrity of paraspeckles[9][10][5][11][6]. p53 has been found to induce formation of Neat1-containing paraspeckles and modulate replication stress response and chemosensitivity, which makes Neat1 a promising target in cancer therapy[6].
Newly transcribed Neat1 RNA nucleates the formation of paraspeckles at its transcription site, recruiting paraspeckle proteins. Continued expression is required to maintain paraspeckles, identifying the dynamic nature of this nuclear body[11]. Literature currently provides conflicting evidence about whether Neat1 v1 is sufficient for the formation of paraspeckles, or if this requires full length Neat1 v2 [10][12].
In vivo however, significant expression of Neat1 v2 appears to be required for cells to form more than 1 or 2 paraspeckles[13]. Neat1 appears to constrain the size and mediate the cylindrical geometry of paraspeckles.
Neat1 short and the identical 5' end of Neat1 long plus the 3' of Neat1 long all localise to the periphery of paraspeckles, while the central region of Neat1 long is found in the interior of the nuclear body[14]. Interacts with paraspeckles proteins PSPC1, PSF/SFPQ and NONO/P54NRB either directly or in a complex[9][10][5]. Interaction of short isoform with p54 requires protein interaction regions near the 5' and 3' of the transcript[15]. Neat1 knockout lead to loss of paraspeckles, however mice were viable and fertile with normal morphology and populations of differentiated cells in one Neat1 v1 and v2 expressing tissue tested[13].
Expression
A summary of differentially expressed lncRNAs in HIV-1-infected Jurkat and MT4 cells [[16]]
Expressed in a wide range of human and mouse tissues[17][3][4][5]. Although expression of the long isoform (Neat1 v2/ Men beta) is much lower than Neat1 v1/ Men epsilon in many tissues[13]. Up-regulation of Neat1 (and subsequent formation of/increase in paraspeckles) may be a general feature of differentiation. Neat1 is up-regulated upon human ESC differentiation[14], muscle differentiation[5]and in-vitro neuronal differentiation[18]. Up-regulated upon infection of mice with Japanese encephalitis virus or Rabies virus[3]. Expressed in the nucleus accumbens of normal human brains and upregulated in this brain region in heroin abusers[19]. In addition, expression levels are elevated in the caudate nucleus of patients suffering from the neurodegenerative condition, Huntington's disease[20]. Localised to paraspeckles within the nucleus[4][5]. Mouse Neat1 found to be highly unstable (half-life <2 hr) in N2A (neuroblastoma) and 3T3 cells, although low stability did not prevent paraspeckle formation[21][7], while human NEAT1 appears to be more stable[10][5][21].
NEAT1 is one of several lncRNAs whose expression is changed by HIV-1 infection[16].
The expression level of NEAT1_1 and NEAT1_2 is likely controlled by HNRNPK, which is a newly identified paraspeckle protein and interferes with the CFIm complex cleavage to keep NEAT1_2 synthesis low[1].
Conservation
Placental mammals. Dog Neat1 is found in several genomic locations, version that is found near single dog Malat1 gene is given below[4].
Regulation
FUS (Fused in sarcoma (FUS) protein, linked to a number of neurodegenerative disorders, is an essential paraspeckle component, and paraspeckles are nuclear bodies formed by a set of specialized proteins assembled on NEAT1) regulates NEAT1 levels[22].
p53 has been found to induce formation of Neat1-containing paraspeckles[6].
Neat1 has also been reported to interact with a number of chromatin binding protein/complexes in mouse embryonic stem cells including PRC1, PRC2, JARID1B, ESET and SUV39H1, with the general pattern being interaction with repressors of gene expression[23].
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Labs working on this lncRNA
School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK [22].
References
Annotation originally sourced from lncRNAdb
- ↑ 1.0 1.1 1.2 1.3 1.4 Zhang, Y., et al. (2014). "Life without A tail: New formats of long noncoding RNAs." Int J Biochem Cell Biol 54C: 338-349.
- ↑ Guru, S. C., et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus." Genome Res 7(7): 725-735.
- ↑ 3.0 3.1 3.2 Saha, S., et al. (2006). "Identification and characterization of a virus-inducible non-coding RNA in mouse brain." J Gen Virol 87(Pt 7): 1991-1995.
- ↑ 4.0 4.1 4.2 4.3 4.4 Hutchinson, J. N., et al. (2007). "A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains." BMC Genomics 8: 39.
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Sunwoo H1, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL..(2009).MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles. Genome Res. 2009 Mar;19(3):347-59. doi: 10.1101/gr.087775.108. Epub 2008 Dec 22.
- ↑ 6.0 6.1 6.2 6.3 Adriaens, C. et al. (2016). p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med.
- ↑ 7.0 7.1 Clark, M. B., et al. (2012). "Genome-wide analysis of long noncoding RNA stability." Genome Res 22(5): 885-898.
- ↑ Gremlich, S., et al. (2014). "The long non-coding RNA NEAT1 is increased in IUGR placentas, leading to potential new hypotheses of IUGR origin/development." Placenta 35(1): 44-49.
- ↑ 9.0 9.1 Clemson, C. M., et al. (2009). "An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles." Mol Cell 33(6): 717-726.
- ↑ 10.0 10.1 10.2 10.3 Sasaki, Y. T., et al. (2009). "MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles." Proc Natl Acad Sci U S A 106(8): 2525-2530.
- ↑ 11.0 11.1 Mao, Y. S., et al. (2011). "Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs." Nat Cell Biol 13(1): 95-101.
- ↑ Shevtsov, S. P. and M. Dundr (2011). "Nucleation of nuclear bodies by RNA." Nat Cell Biol 13(2): 167-173.
- ↑ 13.0 13.1 13.2 Nakagawa, S., et al. (2011). "Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice." J Cell Biol 193(1): 31-39.
- ↑ 14.0 14.1 Chen, L. L. and G. G. Carmichael (2009). "Altered nuclear retention of mRNAs containing inverted repeats in human embryonic stem cells: functional role of a nuclear noncoding RNA." Mol Cell 35(4): 467-478.
- ↑ Murthy, U. M. and P. N. Rangarajan (2010). "Identification of protein interaction regions of VINC/NEAT1/Men epsilon RNA." FEBS Lett 584(8): 1531-1535.
- ↑ 16.0 16.1 Zhang, Q., et al. (2013). "NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression." MBio 4(1): e00596-00512.
- ↑ Peyman, J. A. (1999). "Repression of major histocompatibility complex genes by a human trophoblast ribonucleic acid." Biol Reprod 60(1): 23-31.
- ↑ Mercer, T. R., et al. (2010). "Long noncoding RNAs in neuronal-glial fate specification and oligodendrocyte lineage maturation." BMC Neurosci 11: 14.
- ↑ Michelhaugh, S. K., et al. (2011). "Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers." J Neurochem 116(3): 459-466.
- ↑ Johnson, R. (2012). "Long non-coding RNAs in Huntington's disease neurodegeneration." Neurobiol Dis 46(2): 245-254.
- ↑ 21.0 21.1 Friedel, C. C., et al. (2009). "Conserved principles of mammalian transcriptional regulation revealed by RNA half-life." Nucleic Acids Res 37(17): e115.
- ↑ 22.0 22.1 Shelkovnikova, T. A., et al. (2014). "Compromised paraspeckle formation as a pathogenic factor in FUSopathies." Hum Mol Genet 23(9): 2298-2312.
- ↑ Guttman, M., et al. (2011). "lincRNAs act in the circuitry controlling pluripotency and differentiation." Nature 477(7364): 295-300.
Basic Information
| Transcript ID |
ENST00000501122.2 |
| Source |
Gencode19 |
| Same with |
lnc-AP000769.1-2:3,NONHSAT022112 |
| Classification |
intergenic |
| Length |
22743 nt |
| Genomic location |
chr11+:65190269..65213011 |
| Exon number |
1 |
| Exons |
65190269..65213011 |
| Genome context |
|
| Sequence |
000001 GGAGTTAGCG ACAGGGAGGG ATGCGCGCCT GGGTGTAGTT GTGGGGGAGG AAGTGGCTAG CTCAGGGCTT CAGGGGACAG 000080
000081 ACAGGGAGAG ATGACTGAGT TAGATGAGAC GAGGGGGCGG GCTGGGGGTG CGAGAAGGAA GCTTGGCAAG GAGACTAGGT 000160 000161 CTAGGGGGAC CACAGTGGGG CAGGCTGCAT GGAAAATATC CGCAGGGTCC CCCAGGCAGA ACAGCCACGC TCCAGGCCAG 000240 000241 GCTGTCCCTA CTGCCTGGTG GAGGGGGAAC TTGACCTCTG GGAGGGCGCC GCTCTTGCAT AGCTGAGCGA GCCCGGGTGC 000320 000321 GCTGGTCTGT GTGGAAGGAG GAAGGCAGGG AGAGGTAGAA GGGGTGGAGG AGTCAGGAGG AATAGGCCGC AGCAGCCCTG 000400 000401 GAAATGATCA GGAAGGCAGG CAGTGGGTGC AGGGCTGCAG GAGGGCCGGG AGGGCTAATC TTCAACTTGT CCATGCCAGC 000480 000481 AGCCCCTTTT TTTCCAGACC AAGGGCTGTG AACCCGCCTG GGGATGAGGC CTGGTCTTGT GGAACTGAAC TTAGCTCGAC 000560 000561 GGGGCTGACC GCTCTGGCCC AGGGTGGTAT GTAATTTTCG CTCGGCCTGG GACGGGGCCC AGGCCGGGCC CAGCCTGGTG 000640 000641 GAGCGTCCAG GTCTGGGTGC GAAGCCAGGC CCCTGGGCGG AGGTGAGGGG TGGTCTGAGG AGTGATGTGG AGTTAAGGCG 000720 000721 CCATCCTCAC CGGTGACTGG TGCGGCACCT AGCATGTTTG ACAGGCGGGG ACTGCGAGGC ACGCTGCTCG GGTGTTGGGG 000800 000801 ACAACATTGA CCAACGCTTT ATTTTCCAGG TGGCAGTGCT CCTTTTGGAC TTTTCTCTAG GTTTGGCGCT AAACTCTTCT 000880 000881 TGTGAGCTCA CTCCACCCCT TCTTCCTCCC TTTAACTTAT CCATTCACTT AAAACATTAC CTGGTCATCT GGTAAGCCCG 000960 000961 GGACAGTAAG CCGAGTGGCT GTTGGAGTCG GTATTGTTGG TAATGGTGGA GGAAGAGAGG CCTTCCCGCT GAGGCTGGGG 001040 001041 TGGGGCGGAT CGGTGTTGCT TGCCTGCAGA GAGGGTGGGG AGTGAATGTG CACCCTTGGG TGGGCCTGCA GCCATCCAGC 001120 001121 TGAAAGTTAC AAAAATGCTT CATGGACCGT GGTTTGTTAC TATAGTGTTC CTCATGGCGA GCAGATGGAA CCGGGAGACA 001200 001201 TGGAGTCCCT GGCCAGTGTG AGTCCTAGCA TTGCAGGAGG GGAGACCCTG GAGGAGAGAG CCCGCCTCAA TTGATGCCTG 001280 001281 CAGATTGAAT TTCCAGAGGC TTAGGAGGAG GAAGTTCTCC AATGTTCTGT TTCCAGGCCT TGCTCAGGAA GCCCTGTATT 001360 001361 CAGGAGGCTA CCATTTAAAG TTTGCAGATG AGCTTATGGG GGGCAATCTT AAAAAGTCCA CAGCAGATGC ATCCGGCTCG 001440 001441 AGGGGCCATC AGCTTTGAAT AAATGCTTGT TCCAGAGCCC ATGAATGCCA GCAGGCACCC CTCCTTTCCT GGGGTAAAGG 001520 001521 TTTTCAGATG CTGCATCTTC TAAATTGAGC CTCCGGTCAT ACTAGTTTTG TGCTTGGAAC CTTGCTTCAA GAAGATCCCT 001600 001601 AAGCTGTAGA ACATTTTAAC GTTGATGCCA CAACGCAGAT TGATGCCTTG TAGATGGAGC TTGCAGATGG AGCCCCGTGA 001680 001681 CCTCTCACCT ACCCACCTGT TTGCCTGCCT TCTTGTGCGT TTCTCGGAGA AGTTCTTAGC CTGATGAAAT AACTTGGGGC 001760 001761 GTTGAAGAGC TGTTTAATTT TAAATGCCTT AGACTGGGGA TATATTAGAG GAAGCAGATT GTCAAATTAA GGGTGTCATT 001840 001841 GTGTTGTGCT AAACGCTGGG AGGGTACAAG TTGGTCATTC CTAAATCTGT GTGTGAGAAA TGGCAGGTCT AGTTTGGGCA 001920 001921 TTGTGATTGC ATTGCAGATT ACTAGGAGAA GGGAATGGTG GGTACACCGG TAGTGCTCTT TTGTTCTTGC TTCGTTTTTT 002000 002001 TAAACTTGAA CTTTACTTCG TTAGATTTCA TAATACTTTC TTGGCATTCT AGTAAGAGGA CCCTGAGGTG GGAGTTGTGG 002080 002081 GGGACGGGGA GAAGGGGACA GCTTGGCACC GGTCCCGTGG GCGTTGCAGT GTGGGGGATG GGGGTATGCA GCTTGGCACT 002160 002161 GGTACTGGGA GGGATGAGGG TGAAGAAGGG GAGAGGGTTG GTTAGAGATA CAGTGTGGGT GGTGGGGGTG GTAGGAAATG 002240 002241 CAGGTTGAAG GGAATTCTCT GGGGCTTTGG GGAATTTAGT GCGTGGGTGA GCCAAGAAAA TACTAATTAA TAATAGTAAG 002320 002321 TTGTTAGTGT TGGTTAAGTT GTTGCTTGGA AGTGAGAAGT TGCTTAGAAA CTTTCCAAAG TGCTTAGAAC TTTAAGTGCA 002400 002401 AACAGACAAA CTAACAAACA AAAATTGTTT TGCTTTGCTA CAAGGTGGGG AAGACTGAAG AAGTGTTAAC TGAAAACAGG 002480 002481 TGACACAGAG TCACCAGTTT TCCGAGAACC AAAGGGAGGG GTGTGTGATG CCATCTCACA GGCAGGGGAA ATGTCTTTAC 002560 002561 CAGCTTCCTC CTGGTGGCCA AGACAGCCTG TTTCAGAGGG TTGTTTTGTT TGGGGTGTGG GTGTTATCAA GTGAATTAGT 002640 002641 CACTTGAAAG ATGGGCGTCA GACTTGCATA CGCAGCAGAT CAGCATCCTT CGCTGCCCCT TAGCAACTTA GGTGGTTGAT 002720 002721 TTGAAACTGT GAAGGTGTGA TTTTTTCAGG AGCTGGAAGT CTTAGAAAAG CCTTGTAAAT GCCTATATTG TGGGCTTTTA 002800 002801 ACGTATTTAA GGGACCACTT AAGACGAGAT TAGATGGGCT CTTCTGGATT TGTTCCTCAT TTGTCACAGG TGTCTTGTGA 002880 002881 TTGAAAATCA TGAGCGAAGT GAAATTGCAT TGAATTTCAA GGGAATTTAG TATGTAAATC GTGCCTTAGA AACACATCTG 002960 002961 TTGTCTTTTC TGTGTTTGGT CGATATTAAT AATGGCAAAA TTTTTGCCTA TCTAGTATCT TCAAATTGTA GTCTTTGTAA 003040 003041 CAACCAAATA ACCTTTTGTG GTCACTGTAA AATTAATATT TGGTAGACAG AATCCATGTA CCTTTGCTAA GGTTAGAATG 003120 003121 AATAATTTAT TGTATTTTTA ATTTGAATGT TTGTGCTTTT TAAATGAGCC AAGACTAGAG GGGAAACTAT CACCTAAAAT 003200 003201 CAGTTTGGAA AACAAGACCT AAAAAGGGAA GGGGATGGGG ATTGTGGGGA GAGAGTGGGC GAGGTGCCTT TACTACATGT 003280 003281 GTGATCTGAA AACCCTGCTT GGTTCTGAGC TGCGTCTATT GAATTGGTAA AGTAATACCA ATGGCTTTTT ATCATTTCCT 003360 003361 TCTTCCCTTT AAGTTTCACT TGAAATTTTA AAAATCATGG TTATTTTTAT CGTTGGGATC TTTCTGTCTT CTGGGTTCCA 003440 003441 TTTTTTAAAT GTTTAAAAAT ATGTTGACAT GGTAGTTCAG TTCTTAACCA ATGACTTGGG GATGATGCAA ACAATTACTG 003520 003521 TCGTTGGGAT TTAGAGTGTA TTAGTCACGC ATGTATGGGG AAGTAGTCTC GGGTATGCTG TTGTGAAATT GAAACTGTAA 003600 003601 AAGTAGATGG TTGAAAGTAC TGGTATGTTG CTCTGTATGG TAAGAACTAA TTCTGTTACG TCATGTACAT AATTACTAAT 003680 003681 CACTTTTCTT CCCCTTTACA GCACAAATAA AGTTTGAGTT CTAAACTCAT TAGAATTGTT GTATTGCTAT GTTACATTTC 003760 003761 TCGACCCCTA TCACATTGCC TTCATAACGA CTTTGGATGT ATCTTCATAT TGTAGATTTA GGTCTAGATT TGCTAGCTCC 003840 003841 AAGTAATTAA GGCCATGTAG GAGAGCATGG TAACCACAGA TAGAACTGGT ATTATCCCAA GTGGTCTGCA GACTGCTGAG 003920 003921 TGGGGATGGG ATCTGCTCTC TGTTGAGAGT TGGTAATCAT TGGTTTGAAA TGTGATGAAA CCACTCAAGC CAATGAAGGT 004000 004001 GGGTGTGTAG GTGGGGAGTA CTTTGCCATA ATATTTTAAA ACATTACCTG GTTAGAGTTC TAAGTGGTAC TTATTTTTGT 004080 004081 TTGGTTAGGG GAAAGCCTGA ATAAAAACAG AAATGGACAC ATAATATGCA TATTCCATAG TCTTTGGGAG GCTGGAATGT 004160 004161 GCCTGGGATT TGGGTCTAAG TGTATGCGTA ATTCTTACCT CACTAAAGAA TTTGCCTTGT TTTTTTCCTT TTGGTGAGTG 004240 004241 ACTAAAACGT CTGGGCTTCC CTGTGTGCGT GCTACAGTAA GCAAGCAGAG GCTGTGCAAA GGTGTGAGCA GGATCACGTG 004320 004321 GAATCTGGAG GATACATCTT GGCTTGCAAA CTGCCTCTGT CTCCTGGGTG GGACTGTTCT GTCCTTGCAC TGCTGTTCTG 004400 004401 TGTTACCTCT TGGGGTGTAA GGTTTTGCTT ACAGGAGACA AACTTTGGGC GTAGAATGGA AGCCACTGCC AGCCTCTGTG 004480 004481 CTGAGAAGGA AGGTGCTTGT TTCAAAGGGA GCAGCAAGGG AGGCTTGTTC TACTCACCTG GGCCTGTTTG CCTGAGAAGG 004560 004561 GGAGATAAGG GCTGAACTGG GACTAGCCAG GGGGACCAAC ACAAATGGTG GGGGATCATG ACCTGAAGGA TTCTTTCCTT 004640 004641 CCCATGAGCT GCAGGGCTGG TTGCCGTCCT TGCAACTGTG TCTTATTTGC CTGTGCCGTT ATATCTTGGT GACCCCTCCA 004720 004721 CGTGTACACT ACTGACAAAC GGGTGGAGTG CTGGGGAGAA GTCACTGTGC CGCCCACCTA GTAAACCTTC TGTCTGTGCT 004800 004801 CATGGCATCT CCAAGATGGG GCACTGCTGT GTGCAGAATC CAGGGTCCTC TTTCTGCTTG CAACTCCTTT CCCTGGATGC 004880 004881 CCCAGAAACA ATCCAGGCCT CCTTTCCTAT CTTACCCCTT TGCTTTGCTT TTTACCCCAG CACCTCTATA ACCGCCTTCT 004960 004961 CTTCTTTTCA GAACTCCTTG TTTCTCGTCC TGTTTTTTAT GATTACAAAA CTCTTGCTTC CACCCTGGAA GATAACTGCT 005040 005041 ATAGATGCCT GTATGTAAAT GGTGCTGTCT CCAGCAACTG GCATGCTGAA GAAGAATTGA TTCACGGGGT ATAAATGTTG 005120 005121 GGGATTGGAA GTGGGGATGA AATGGCACTT GTTGATACAG GAGCAGAGAG GTGAGGCCGA CTGCTGAAGA CAGCTCGCCA 005200 005201 CCCTCCTTGC CTCCACTCCA ATCCAGGGGC TGGGGCCACA TTCTTTGCCT TCATTTATCC TCAGATCAGG TGAGATCGAC 005280 005281 AGGAGGTGTT GATGGCAGTG CCAGCAATTA TTGCTAATCC GTTTGCATCC TTATGCATAG ATCTGAATTC AGACTTTGTG 005360 005361 AATTTCCAGA GGTGTGGGTA ATATAATAGA ATTCAGTGAG TGGGCATGGC TGATCTTGTG CAAATTAAAA GTTATGGGGC 005440 005441 ATAAGAATAG CAAAAGTTGA ACTTCTTTTA AAAAGGAAAG TACCCTGAGA GCCAGTATTG GTTGAGGCTC TTCAGTATGC 005520 005521 CCAGGTTGGC AGCACTGAGA ACCGCAGGAA CGGCCTGTTG TTACAAAAAG GAGATTGACT CAGCTGCCCT TGGTGCATCT 005600 005601 GACTGACTAT GACTGCTGAG AGATTCCAAG GACCCTTAAT GCCAGGGCTA ACCTCTCCAT GTGCAGTGAG ACCTCTGGAG 005680 005681 GAAGTGTCAT CCTCTGGCTT TGTGTGGTAC TCATTATGGT GCAGTGCGGG CATGAAATGA AGACACCCAA ATAGGCTTAC 005760 005761 AGATACGATA TGTTTTAAAT GTTCGTATTT AACAAAAACA TACTGACACT GTTTGGAAAT GGCAACAGGA AGATAGCAAA 005840 005841 ATGAATACTA ACATTACGAA AAGATGAACA GGTACATGTT CCAAGGCAGG TGGCTGTGAA CTTCCTCTGA GTGAAGGCAT 005920 005921 CCCCTCCAGC ACCTTTCAGC CTGCTAGTTA GGACGACCCG CCGCCACCCT CCAGGACCTC CAGCCCTGCA CTGCCTTTCC 006000 006001 TCTCTTTTAA ATAATTCTTC ATTGAGTTCT AATATGTAAA AAAAAAAAGT TTACTGTAAA GTTTGCAAAT AAGGAAATTT 006080 006081 TTTTTAAAAG TCCTCAGTAA TCTTACCAGT AACAATTGTT ATGGGCACAT TTGCTTTTGG AAGATTTCTT TTGTATGCAT 006160 006161 GGGATAAGTA CATTTTTAAA CAAAAATGGG ATTATGCCAT AAATTCTATT TTGTGACTTT AATATATAGT GAACACCTTT 006240 006241 TTTAATGATG ACAGGATGTT CCCTTGCATG GCTGTATCAA TTTAAACAAT CTTGTTTCAA TGGGCATACA GGGTATTTTC 006320 006321 TAGTTTTTTT TTCCTCTTAG AAAATAATAC TTGCGATGAC TTTCCTTGTA GCTCAGACTT TTTCACGTCT GTTGTTATCT 006400 006401 CTTTGGGAAT GCTGAATACA TACATTTCGA GAAGGAAATG ACTGTTAAAC TCTTAAGACT TCAGGTTCAT ATTGCTAAAC 006480 006481 TGCCCAGCAG GGAGGGATTT TTTCAATTAG TGTTCTCACT GGTGAGGCAA ACCTGATGCC TTCCCCTCTT CCTCAGAACC 006560 006561 GGCTTTATCA CATTGAAAAC CTTTGCTCCT CCGACGGATC GAGTCTGCTT TCCCTCTGGA TGTGAGCATT GCTTTGTCTG 006640 006641 CTGGTGACTG AACATCTCTA CCTTGTGTCA ATTGGCCATT TGTGGTGTGT GTGTGTGTGC GTGTGTGTGT GTGTGTGTGT 006720 006721 GTATGATTTT CTAATTCCTA GTCATTTTTC TATTGATTGT TTTGCAAAAG CCATTTACAT CTTAAGGATA TTGATAATCT 006800 006801 TTTGTTATAT TTGATGCAAA TATTTTTTTC CAGTTTATAG GTTGCCTTTT AATTTTGTGT TTCAGGTAGA TAAAAGTTAA 006880 006881 ACGATTTTCT TAGGTTAGTT TATCACTGTG GTTTCTGAAC TTGTTATGTG TAGATCTTTT CCACCCCAAG AGTACATAAA 006960 006961 TATTAATCCA TACTTTCTTA TGGAACTTGT ATGGTTTCGT TTTTTACATT TAAACCTTCT TCCCCGTGGT GTGTGTTGTG 007040 007041 GAATCTGTGT TTGTGTGAGG AGGGGCATGG TGCTCTCAGA ACCCACCTCC TGTGGCCAGA GAGCCCTGTC CTGTGAGGGT 007120 007121 GGTTGTCACA GTGGCAGGGT TCAATTCAGA AGACCTTGAG GGCAGGCTGA TGTTTCCTGA ATGGGCCCCT GGTTGTTGCT 007200 007201 TGTCCCTGAC TCTCCATTTC CCCATCTGAG TGGATTTGGA CCTAATAGGG CACTGGAGCT GGTTCGAATC CTGACTGGAC 007280 007281 TACTTGGCAA CTTTATGTCT GGGAGCAAGT TACTTAACCT CCCCAAGCCT GTGTCTGTGA AATGCGGGTA AATGAATGTA 007360 007361 GATGTTTGGC AGCAGCTACT CCTTGTTGAG CTCTCACAGT GAACTCTCCT GCCTCTGCCC TCCTTCCCCG CCTCCCCTGG 007440 007441 TGCCTAGCGT CAGGTCTAGC CACTTCCTCC TGGGCCCCTC TCCCTTTTCT GTGGCTGGCT GCCTGCCCGC CTGGCGCTGG 007520 007521 ACCTTTCATG TAACGGGAAT CAGCATGTAT ATTCTGGTCT GGTCTGTTTC TACACTTAAT TTTGTTTCCA GTAGTATTTC 007600 007601 CCTGTACCGG CAGAGTTCAC AAACACATTT GAAGAGGCTT TTTCTCAGGA TTCTTAACCT TCCCAAAGGA AGTCCCATGG 007680 007681 ATGGGTTTCT AGAAGTCTAT AAATGCTCTG AAATTGTATT TTTCTGTGGA AAGCATAACT TTCATCTGCT TGTTCGTGCT 007760 007761 CAAAAAAGAT CATGAATGAA TGATTGCATG ATTTTATGCC ATTGTGCTTA TACTAAAGGA TATGTAGCCC ATCTCTTGAG 007840 007841 CTGTTAAACT GTTTTGACTA CTTTAAATCG TGCAGCTGTG AGCATCTCTG TAAATTTAGT GTACACATGT ATCCCCTGGA 007920 007921 GTGGCATTGC CTCGGCAGTG AGCACTTATG GTTTTATAAC TCTCTTCACA GACTCAAATG ACTCCAGAAA GCTACACTTC 008000 008001 CTGTTGTGAG TATATGATAT CCATTTCCCT ACATAGCCAC TAACATCAGG TTTTTACAAT TTTATTTATT TCTTGCTACT 008080 008081 TTAAGAAATT TTTGTGGTGA AATACATATA ATAGAAGTTG ACTATCTGAA TCATTTTTAA GTATACATTC AGTAGTGTTA 008160 008161 AGTATGTCGC CATTGTTGTA CAACCAATCT CCAGAACTTT TTCATCTTGC AAAACAAACT CTGTACCCAT TAAATAACAT 008240 008241 TAAACATTCC ATTCCCTCCA GCCTCAGCAA CCCCATTCTA CTTTCTGTTT CTGTGAGTTT GACTATTCCA AGCACTTCAT 008320 008321 ATCAGTTAAA TCATGAAGTA TTTGTCTGTC TGTGACTGGC TTATTTCTCT GAGCACAGTG TCCTCGAGAT GCGTCTATGT 008400 008401 TGTAGCATAT GTCAGAATTT CCTTCCTTTT TAAAAGATCC AAATAATATT CTTATTTTAT ATCTTTTTTT TATCCATTCA 008480 008481 TCCATTAGTG GACACTTGGG TTGCTTTTGG CTATTGTAAA TAATGGTGCT ATGTACAAAT ATCTATATTA TTGTATTTAC 008560 008561 AAGTATAATG CTGTAATGTA CACACATCTT TTTGAGATCC TACCTTCAGT TCTTTTGAGT ATATAGCCAG AAGTGGTATT 008640 008641 ACTAAATCTT ACGATATTTC TATTTTTAAT TTATTGAGGA ACCACTGTAG TTTTTCATAG CAACTGCACC ATTTTACGTT 008720 008721 CTCACCAAGA GTGCACAAGG GTTCCGAGGT TCCCACATCC TCCCCAACAC TTGTTATTTT CTGCTTTTTT TAGATTGCAG 008800 008801 CCATCATAGT GGGTGTGAGG TGACATTTCA TTGTGGTTTT GATTTGCATT TCCCTAATGA GGAGTGATGC TGAGCATCTT 008880 008881 TTCATATGCT TACTGGTCAT TTGTATGTTG TCTTTGGAAA AATGTCTATT CAAGTCCTTT GACTATTTTA AAAATTGGGT 008960 008961 TATTAGAGTT ATCGTTGTTG TTGACTTGTA GGAGTTTCTT TCTATATTCT GGATATTAAT CCCCTATCAG ATATATGATT 009040 009041 TGCAAATATC TTCTCTTATT CCATAAGGTT ACTTTTTCAC TTTGTTGATT GTGTTCTTTG ATGTATAGAA GTTTTTAGTT 009120 009121 TTGAAATAGT CTAATTTATC TGTTTTTACT TTTGTGGTCT GTGCTTTTGG TGTCATATCC AAGAAATCCT TGCCAAATCC 009200 009201 AACGTTATAA GGTACTTTTA AGGTATTTTA GTTGTCTTAG TCTATATTTC TGTACTCACC TTTCTTTATC CACTCATCAG 009280 009281 TTGATGGGCA TGTAGGTTGG TTCCATATCT TTGCAATTCT GAATTGTGCT ATGATCAGGT GTCTTTTTAG TATAATGATT 009360 009361 TACTCTCCTT TGGGTAGATA CCCAGTAGTG GGATTGCTGG ATCGAATGGT TTTTATAATT TTCTATTTTA CCACAGTTTC 009440 009441 TCTCTGCATT TTTCCTCTTT GACCACTAAC CATGTGAAAT TCTCATATTG ACCTTTATAA TGATCATGAA CTCTTAGTAT 009520 009521 CATTGGGAAG GCCACATTTG CCACTTATGA TTGTAAACCT TATCCTCCAT TTTTCCTGTT ATTGTTGGTG CAAAAAGCAC 009600 009601 CTATTATACC AGGACTTTAA AAATCAGTCT GATAAGTCTT TGATAAGTCT AATAATAATA ACTGATAAGT CCATTGAATT 009680 009681 TGCTTCTGAT TACTTTTTCT TTAGTAGCTA AACATGTATG TACTCCTATG ATTACAATGA ACACTCCTCT CCATTTAAAT 009760 009761 TAATTATTTA CATTGATGAA ATAGCAAAAT GTTAATGACT AAATACTGTC TTGGTTTTTT CGTTCCAGGT CAGTCAATAT 009840 009841 TAACTTCTTA TAATTTTCTT TTTTTTCTTT ATGTGTGTGT GTGTGTGTAT TTTTTTTTTT TTAATTTCAA TGGCTTTTGG 009920 009921 GGTACAAATG GCTTTTGGTC ATATAGATGA ATTCTACAGT AGTGAAGTCT GAGATTTTAC TGCACCGGTC ACCTGAGTAG 010000 010001 TGTACATTGT ACCCAATATG TGGTTTTTTA TACCTTGCCC CCCTCTTACC CTCCCCACTT TGAGTCTCTA GTGTCCATTA 010080 010081 TGTCACTCTG TATACCTTTT TGTACCCATA AGTTAGCTCT CACTTATAAG TGAGAACACA CAGTATTTGG TTTTCCATTC 010160 010161 CTGAGTTGCT TCACTTAGAA TAATATCCTC CAGCTCCATC CAAAATTGCT GCAAAAAAAA AAAAAACCAC AAACATTATT 010240 010241 TTGTTCTTTT TTATTGCTAA GTCATATTCC ATGGTGTAGA GATACCACAT TTTATTTATC CACTCACTGG TTGATGGGTT 010320 010321 GGTTCCACAT CTTTGCAATT GTGACTTGTA CTGCCATCAA GTGTCTTTCT GGTATAATGA CTTCTTTTCC TTTGGGTAGA 010400 010401 TACCCAGGAG TGGGATTGCT AGATCAAATG GTTCTTAACA TTTTCTCTCT GGATCTATTT CTGGAAATTT TAGGCTCCAG 010480 010481 TTTTTGTTGT TGTTGTTAAT AAAATGCAAT GGAATGTAAT GATCATCACT TTTCATTATG CTTTAAAATC TGGTAAATGG 010560 010561 AGGCTAGAAC ACTCCTGTAA GGCAAGAATA TTCTCTCTGT TGGAACTCAA ATACACAGAA CTGGGTAAAT CTCAATCTTA 010640 010641 ATCTTTGATT CAGGACACAA CATGGCTCTC TTTTACTTGC TTTCTTTAAT TGTTTTTTAA TAATGTGGTA AGCATTTCTG 010720 010721 AATCTCCTAT CCAATACAAA AACTAGGACA ATACAGACAG TAACTCCTAT GGTTACAATG AACACTCCTC TCCACTTAAA 010800 010801 TTAATTATTT ACACTGATGA AATTGAAATA GCAAAATTTT AATGACTAAA TACTGTCTTT GATTTTTTGT TCCAGGTCTG 010880 010881 TCAATATTAA CTTCTTATAA TTTTCTTTTT TTTTCTTTAT GTGTGTGTGT GTGTGTGTAT ATATATATAT TTAATTTCAA 010960 010961 TGGCTTTTGG GGTACAAATG GCTTTTGGTC ATATATATGA GTTCTACAGT AGTGAAGTCT GAGATTTTAC TACACCTTCC 011040 011041 ACTTATGTGG TCCCACACCA CCCGCCTCCC CTGCCGCCTC CTGCCACCCC CTAGGCCAAG GTAATAATCA TCCTGAATCC 011120 011121 TGGGTTTATC TCTCACTTGC TTTCTTTTCA TATAATTTTG CAAAAGAATC TGATCTAAAT GTGTTTTTCA GAGTATATAT 011200 011201 TTATATTTTA GCTGTTCTTA GAGAAAATTT ATTATTTTGC ATGTAATCTT ATGGAACATT CTCATTTAAT ACCATGGTAA 011280 011281 GATTCAGCCC TTGCCCAGGG GATAGTTCAT TTAGTTTGTT TACTGGATAG AGCTCATCAT GTGACTATAC CTCAGTTAGT 011360 011361 TTATCAGTTC TCCCATCCAT GGTGACTAGG TTGCCTCTCA GCCTCTCAAC AACACTGTTT CTCAGTGTCC TTGTAGAAGT 011440 011441 GATATGTGGG TGTTTTCTCC TTACACAGAG TTGAAAGGTG ACGACAACAA CGTTGGCACT ACCAATCCCC CACCCTCCAG 011520 011521 AGGGGTAACC AGTGTTACCA GTTTGCTGTG TTTCCTGCTA CACCTCGCCT TATTCACTTC CATTTGTATC TGAAAAACGT 011600 011601 GTTGCATGGT TTCTTTTCTA TAGAAGTGGT AAAATGCTAT TGTGTCCTGT ACATTATTGA TTACTTTTTT TCATTTAACA 011680 011681 GTAGGGAGAT GCCTGGGAGT ACACAGAGAA CTGCCCTCAT TGTTTTCAAC TTCTGCACTG TATGTCTGTG AGTTTAGCCA 011760 011761 TTCTGCTGTT AATGGAAATT TACAGTATTC TAATCTTTTG ATATTACAAA CAGTTCTGTG CGATCATCGT CATACACAAC 011840 011841 CCCTTGTGCA CAATGCATGA GTGTTTCTCA GGGTAGGTAC CAAGAAGTGA AATTCCTGGG TCATAGGGCG TGAGTCCGAC 011920 011921 ATTTTTCTCC ATTCTGCCCT GTTGCCCTCC AGAGTGGGTG TCCAGCTTTG CATACCTAAG TATGAGAGTA TCTGTTGTTC 012000 012001 ATATCCTCTA CGACGCTCCA TATATGAAAC TTAAGTTTCT GCTAGTTGCC ATCTTTGATC TATCATGTAT GCAGTGACCT 012080 012081 ACTAAGACTG TAATTGGTAC AGTAGATTCT TGTCATCTGT GTGTGAATTT AGCATTCATG GGCTTAATGC TGACAAGGCC 012160 012161 CCCAGGGTCC AAGACATATA ATCATGTATA ATTTTGTCAA GGTATAATTT TTTAAATTGC TTTTGTCATG TGTCTGCTGG 012240 012241 TGATGCCCAA CCCAGTGCTC TGCACCCAGG TCACACTGTG GCTTTGTCCT CTGCTTATGC CTGCATTGCA GCAACTGTCC 012320 012321 TGAAGAGACC AAAATTATGC AGATTTAGGT AAGTCCATGG CTAATGTTAT TATATTATGT GCTATTGTAA TGGATGGGGC 012400 012401 TGTGGAGTGT ATGAATTTAT AAATCACTGG TCTTGTAATT AAAATTCAAA CACTATAGAA AAAGGCCATG TAGAAGATAA 012480 012481 AAGTTCCTCT ATAATCCCGG ACCCCTAAGA TAACTACTAA TGACAACTTC ATTTATATTC CTTCAGACAT TTTCTGGCTG 012560 012561 TGGATGTACT AAAATGTATC CTATTATTCT CTGCCCTAAA ATGGAATCAT ACAAGGTGTA CTGTTATTTT TATGGCTCTA 012640 012641 TAACATGTCA TATTGTACGT GTTGGTATGG TCATTTTAAC CATTTTTCTA GTGATGGCTT TGAGGTTATT TGCAGTTTCC 012720 012721 TAGCCATCTC AAAGTGTGCT GCGGGGATCT CTTTTGCATC CCTCTGGGTG CAGAGCTGAG GCACCCAGAG GCAGTGTCCA 012800 012801 GAGGAGGCAG CATCTGTAGG TGTCTTCACC TGCTCTGGCT CTTGGCACAT CTGGTTGGTG ACACTGTTTT GTGAGATGGG 012880 012881 TTGAAAGCAC GTGCTGCCAA AATAGAATAA TGTTGGTCCT CTCCTCATGT GCCGTGGAAC TGGGGTAAAA CTGCGTAGTG 012960 012961 GCTGCAGCTG CCTGTCCATA CCGGAATCGA GTATAACACG GTGCCTGGCT TAGCACAAAA CAGTAGTGGG TCCTGCAGGC 013040 013041 CCCAGAGTCT AATTCCTGGT ATTCTTTCCC CTACACAGAT TAAATAAACC AAAAACAAAC TATTCTAGGA AAGCGTCTGT 013120 013121 GACATTTGTA AAAAGTGGTA TTTAATGATC TTTTATTCAC TTGTCTGTTT AGTTTGTTGA AATCTTAAGT GGCATCCTGG 013200 013201 TCTGGGAAGG AGTGCTGTCT GCGCCTGCCC TCCGCTGGGC ACAGCGTGGC TGCTTCAGGG GCTAAGCACA CACTTTCTGT 013280 013281 CTTCTAAAGG GCCGCCACAT GCCAGGAGCT CAGGTGTGAG CCCGGCTCTG GCTCTTACCT CATAGGGTCA CTCATAGGGG 013360 013361 CACAGGGAGC AGAACATTGT ACACAGCGAG GCACCACCCG GCTTGGCATC TGCCTCGGTG GACTTACTAC CTCTAGAAGG 013440 013441 AAATACCTGA GTTCCTCTGG CCTCAGCTCC TAGAGTGACT GGTGTGCTGT CCCTGTTACT CTTCTGTCAA GGTGACAACT 013520 013521 GTGTGACCCA TCATCTGTGT GTCAAAGCAA GGCCCTGCCT GGGCCTCTGC TCCTGTGCTG ACCCCAAAGG CAAATGCTTT 013600 013601 GCTAGTTTCC TTCCAGTTAA TTTCACCTAT GAATAGATGT GTGAAAACTG TTCAAAGCCA TACCTGCACA TGTTTGAACT 013680 013681 TCAAACCCTG TGGGTGATTC AGTGGCATCT TTCTCTAACC CCCAGCCTCC CTTCCCACAG AGGCCACCGT CATGGCCAGT 013760 013761 TGCTGCAGTT TCTTTCCAGA GAACCTGTGT ATGTGTAAAG CTGTACAGGC GTGGGTACAC CACACAGCCT GTCTTGCACT 013840 013841 GTGGACTGTT GAGTTACTAG TACATCTAGG TAAGCACCGC ATATCTGTAT TCATGTCTGC CTTGGTCTTT TCAACATCTG 013920 013921 TGTGGTAGCC GTGTTTGAAT TACCCATTCC CTTTTTGGGG AACCATTAAG TTGTTTCAGC AATTTTTACT GTAGATAAGG 014000 014001 CTATACCGCA TATCTGTGTA CATGGGTTTT TATGTACATG GGCAAGTATA TCTGTGAGAG AAAAGTTTCC TCAGGAGGAA 014080 014081 TTCTGGGCAC AGCATGTGTA AATTTCTAAA TATGATGGAC ACCCCCAGCT TCCACCTCAA GGAGGTTGGT CCCATTGACA 014160 014161 TTTCCCCACA CCTTCACCCA GGCTGTGCCC TTAAACTTGG TTATTTGTCA ATGTGAGAAG TGGAAAATAG TATTTAATTG 014240 014241 TAGTTTGGAT TTGTATTTCT ATTGGGTTGT ATACTTACTG ATTAATAATA AGAGCTCTTT ACATATTAAG GAAATTAACC 014320 014321 CTTTTCAAAT ACATTCCTAT TTCTCACTAA TCTTTAAGTT TTATTGTAAT ATTTTGCTCT TTAGTTTATA TATATATGTA 014400 014401 TATATATATA TATGTATATA TATATATATA CATATATATA TACATATATA TATACTAATT TTCTTTTATG GTTCCTGGAT 014480 014481 TTTGTGAGTA GTTTGAAAAG GCTAATCCAG CTGAAGATTT TGTTGTTGTT GTTAAACCCC ATGTTTTCTC CTAACTCTTT 014560 014561 TTATTTTTAT TTTGGAGGAC TCTATCTAGA CTTAATTTTA GCATAACAAG TGACAGGGTT AGTTAGCCTG TTGTCCTTAC 014640 014641 ACCATTTTCT GGCTAATACA GCTATTAACT ATTGATCTGT CTATTCACGT GCCAGTTCCT AATGGTTTTA CATAGTGTAA 014720 014721 TCTGCACTTC AAAATAGCGA AGGGAAGCCC TACCTCATTA TTCTACTTTT CCAGAATTCT CCTGGCTATT CCAGGCTGCA 014800 014801 TGTTTACCTT AACCTTCCCT GTGATGTCTT CATGCCGTTG TCTTCTTATG CAAGAATAAG GTACGTCTTT CCATCCACTC 014880 014881 ACGTCTATTT AATTTGACTT TGCATTACAC AGAAAGCTGG TCTTGGTCTG TCTACCTCGG CATCTAGTTG TCCTCACTGC 014960 014961 CCCCTAGCCG ACCCCACCCC ATCTGACTGA CTACCCCATC ACAGAGTACT TTTATTTACG TTTTGCTCTG CCTAATGGTT 015040 015041 ACTTGATACT GTCACGCCGA CAGTGTCCAG TTCAGTGGTC TTTGCAGTTG AAATGCTCCC GTACACACTG TCTTGTTAAA 015120 015121 AATGCCAGTA AGTTCATACA AACCCAGCTT GCACCCAAGG TCACATTCAG AGAGCGTAGG GCTGGGATGG GTTGTTTTCC 015200 015201 AAGCTTCTGC CACTGTGTGG CTAGCTCTTC CCACTGGGAA GTTCTGTGTA CCCGGAATGT CGGAGTGGAG TCCTGTTCTA 015280 015281 GTGTCCAGCA CCTGACCCTG TGCCCAACCC CTCAACAGCC TATTCCTGCT GTCCACAGCC TGCTGGAACT TTTTACAAAA 015360 015361 TATGTTGCCA TGCTGGACCC TGGGCACTGG ACATAAGCCC CCTGGCAGCC TTTTTCATGT CACCCAAAGG GGTAATTGTC 015440 015441 CTACTGGTGG TCTGTAAGAT GAGTTAGGGT GACTTGCTAA TAGACATTGT AAATCTTAAT ATTTATGTAT GTATTTTATT 015520 015521 ATTACCGGTT TTCCATTTAT GATGGTAATA TTGTTTCTTC TAAGAATATT TATTTTTCCT TCTAAATATT GAGATAAAAT 015600 015601 TCATGCTTTT GAAATGTTCT ATTCAGTGGC TTTTAGTATA TTTGCTATGT TGTGCAACCA TCGACACTAT CCATTTCTAG 015680 015681 AACTTTTTCG TCATCCCAAA CAGACGCTCT GTATTCATAA AAAAATAACT TCCTACCTGT CTCTCCCCCT AGTCTTTGGT 015760 015761 AACCTTTGTT ATACTGGTAA ACTTTGTTGT GCTCTCTGTC TGTGTGAATT TGCCTATTCT AGGGGCCTCA TATAAGTGTA 015840 015841 ATCATACAGT ATTTGTCTTT TTGGGTCTGT CTGATTTCAC TTAGCGGGTT TTCAGGGTTC ATTCATGTTG CAGCATATAA 015920 015921 CAGTACTGCG TTCCTTTTTC TGGCTGAATA ATATTCCACT GTATGGATAG ACCCCATTTT GTTTATTCAC ACATCATTTG 016000 016001 GACATTTGGA TTATTTCTGG TTTTTGGCTA TTATGAACAA TGGTGCTATG AACAGTTGCG TACAAGTTTT TGTGTGAACA 016080 016081 TATGTTTTCA ATTCTCTCAT TATATACCTA GGAGTAGAAT TACTGGGTCA TATGGTAACT GTATATTTTT GAGGAACTGC 016160 016161 CAAACTATTT TCCCACGTCC ATGCACCATT TCACATTCCC ACCAGTAAGT AAGAGGGTTC CAATTTCTGC GCATTCTTGC 016240 016241 CAACACTAGT TATTATCTGA CTTTCTGGTT ATAATCATTC TAATGAGTGT GAAGTAGCCT CTGGTGTCAT TTGGATTTGC 016320 016321 ATTTCTCTGA TGAGTGATGC TATCAAGCAC CTTTGCTGGT GCTGTTGGCC ATATGTGTAT GTTCCCTGGA GAAGTGTCTG 016400 016401 TGCTGAGCCT TGGCCCACTT TTTAATTAGG CGTTTGTCTT TTTATTACTG AGTTGTAAGA GTTCTTTATA TATTCTGGAT 016480 016481 TCTAGACCCT TATCAGATAC ATGGTTTGCA AATATTTTCT CCCATTCTGT GGGTTGTGTT TTCACTTTAT CGATAATGTC 016560 016561 CTTAGACATA TAATAAATTT GTATTTTAAA AGTGACTTGA TTTGGCTGTG CAAGGTGGCT CACGCTTGTA ATCCCAGCAC 016640 016641 TTTGGGAGAC TGAGGTGGGT GGATCATATG AGGAGGCTAG GAGTTCGAGG TCAGCCTGGC CAGCATAGCG AAAACTTGTC 016720 016721 TCTACTAAAA ATACAAAAAT TAGTCAGGCA TGGTGGTGCA CGTCTGTAAT ACCAGCTTCT CAGGAGGCTG AGGCACGAGG 016800 016801 ATCACTTGAA CCCAGGAGGA GGAGGTTGCA GTGAGCTGAG ATCATGCCAG GGCAACAGAA TGAGACTTTG TTTAAAAAAA 016880 016881 AAAAAAAGTG ACTTGATTTA AGGGAAAAAA TGACTGGCTA TATTCAGTCA GATATGGCAA AAAGTCTCAA GGTGTTAATG 016960 016961 TGAATGATTA AGGTCTTGGG GGGGGTGTCC CCTATCAGAC TACAGGTGTT TAGAGGCACA GAAAAAGGTG CAGTTGGGTT 017040 017041 CTTAATGTGA AATGATGAGA AGCACAACTC CAGTGTGTCT CTTTGTGTAG AATGTCAGCA GACACCCCCT GCTAGATGTG 017120 017121 CTGGATCATG GGAAAGCATT TCCATTTGTT ACTAGATTGT TCAGAAGTTT TAATTTATGA TGGGTGTGGT GGCTCATGCC 017200 017201 TGTAGTCCCA GCACTGTGGG AGGCTGAGGC AGGAGGATCA TCTGAGGCCA AGAGTTCAAG ATCAGCCTGG GCAACATAGT 017280 017281 GATACCCTAT CTCTTAAAAA AGAAGAAGTT TTTAAATTTG AAATAATAAT AGGTACTGGA TTTATGCAAA TGTCTTTTCT 017360 017361 GCGTCTTTTG AGATGAGTAT CAGGTTTTTT TTTTTCCTTT TATCATCTGA TGATGAACTT AATGTTTCCA TTTGTATTAA 017440 017441 TGGAATACTA AGTCCCTCTG TGATTTCTGA ACCAAGCTAT TCCTAGGCCT GAGTTTTATT TTGTTGACAC AGAAATAAAT 017520 017521 TAGAAGGCCA AGCGTGGTGG CATGTGCCTG TAGTCCTAGT TGCTGAGGTA AGAGGATTGC TTGAGCCCAG GAGTTCAAGG 017600 017601 CTGCAGCAAG CTTTGATTGC GCCACTGCAC TCCAGCCTTG GCGACAGACT AAGACGCTGT CTCAAAAAAA AACAAAAACG 017680 017681 ACAAAAAAAA AACAAAACAG AAAAAATAAA CTAAGGCAAT GACAGTCCCT GGCAAATGCT GGGAGGGAGG CAGCAGTGGT 017760 017761 CAGGGAAGGT AACCCTGAAG CAGGACTTGT AAAGCAAATA AGATTGGGAG GCCAAGGTGG GTGGATCACG AGGTCAGGAG 017840 017841 TTCGAGACCA GCCTGGCCAA CATAGTGAAA CCCCGTCTTT ACTAAAAATA CAAAAAAATT AGCCAGGTGT GGTGGTGGGT 017920 017921 GCCTGTAGTC CCAGCTACTT GGGAGGCTGA GGCAGGAGAA TCTCGAACCC AGGAGGCGGA GGTTACAGTC AGCTGAGACC 018000 018001 GCACCATTGC ACTCCAGCCT GGGTGACAGA GCAAGATTCC GTCTCAAAAA AAAAAAAAAA AAAAAAACCA AGAAGAAAAG 018080 018081 GAATGAATTA GAACTTCTTC TGCTTGGACT TAAGGGCATC ATCAGGCAGG TTTTGGGTAG GATAGCAGGG GAGGCAGAGA 018160 018161 CATAGTCGGG GTCAGTGGTC ATGAGTGTGG CTTTGAGCCC AAAAACTTGG TTTCTGTTCC CTACTTTGCC ACTCAGTAGT 018240 018241 GCATGACTTT GGCCAAATTT CTTAAATTCA TGAAGCAAGT TTCCGGGTGA ATGAAATGGG GATAAAAATA GTGTTCAAAC 018320 018321 CTATCCGTTG GTTTGTGTGA AACTGAAATG AATAGTATCG TGCAGGTACT TGTGAGCAAG GGGAGCTGCT GTTTCCTGTC 018400 018401 CCTTTATGAT GGGAAATATC TAGACAAGTT CCCAACCCTC TGCACTGCAG GCTGCATGGC ACGGAGGGTC TTGTAACACC 018480 018481 AGCTGGGGCT GGCCTTCTTT TAGGAGCTTC AGTGGTTCTG AAAACTTTTA TTTGTTTGTT TGTTTTAGTA GATGTGGGGT 018560 018561 CTTTCTGTGT TGCCCGGACT GGTCTCAAAC TTCTGGACTC AAGTGATCCT CCCCCGCTCA ACCTCCCAAA GTGTTGGGAT 018640 018641 TACAGGTGTG AGCCACTGTG CCCAGCCTTG AAAACTTTTT CAGGTTCTTC CAGGGTTACT GGGCTATTAA ATATTTCTAT 018720 018721 TTCATTATAA GTCAGTTTTT CAAAGTTATA TTATCTTAAT TACCTTTTTT ATATGTATTA GTGTAGAGTA GCATTTTATA 018800 018801 TTTTGATATC CTCCTTATGC ATAGTTTTTC ACTTTTTATT CCTAGTTTTT CGTTTTTAAT AAGACTTTCA AGAAATTTAT 018880 018881 TTTATTGGCC TTTTGAAAAA AGCAGCTTTA GATAAAGTAA GCAGTTCTGC TTTCATTTTA TAATTTATTT CTACTTTTGT 018960 018961 TTCATTAATC TTTTCCTCCG GCATGCCTTG GATTTTGTTG TGTTACTCTT TTTCTAGAGG CTCGCATTGT GTGTCTGGTT 019040 019041 CACTTATGAT CACGCTTGCC TACTTTTAAG AATGGAAGAG GGGAGGTGGA GGGTGGCTGC ACAGTCGAGG GTGTGAGGCA 019120 019121 GTCTTGCTCT AGCCCCACCA TGCCCTCAGC CCGCTGTGGC CACGCTGGTT CCTCAATTGC TGGGGCGTGC AGTGTCTGTA 019200 019201 AGGGAGGCTA CTGATGCCAT CCGAGGAAGA TGTAAGGTTT CGTGTGGGCA GCGAGAGCCT AGCAGGCATG TGGGGTGCCC 019280 019281 AGCAAAGGGT AACAGTGGAC AGTTGTTGCC TCATTCCACA GAGTTTTGAT TTTTTTTTTT TTTTTAATGG TCACTCCATC 019360 019361 AACATCCCCC ATGGCCAGAG CCTGAGCTGG TCCCCAGAGA CACAGGCATT CAGCTGACAG CCTCGCCTTC ACGCTGCTGC 019440 019441 TGTTCTCATG GGGGACAGGC CTCAGGTGGC AATGCACAAA TCATTAGTTA AGGGCAGTTG TGACAGTTAC CAAGGAGTGT 019520 019521 AGTCCCCCGC CCCCCGCCCA GTGAAAACAG CCCTAACCAG GGGTGGGGAC CTTTGGGCTC TGACCCGAAG GGTAGGAGAA 019600 019601 GCTGGAAGGA CAGCATTCCT GTCTGCGAAG GCAGGAGCAA AGCTGCCAGG CTATGAAGGA AATGGCTGGA GCCTGAAGTC 019680 019681 ATGCAAGCTG GGGCTGGCAG GGACAGGGCC AACTTCCAGG CCTGGGGGCC ACCATGAGGA TTCAGGACGT GACCCCCAGG 019760 019761 GCACATGAAG GCCTTCCATC TGTATTTAAG AAAAGACTTT ATCAGACGAG TATGGTGGCT CACGCCTGAA TCTTAGCACT 019840 019841 TTGGGAGGCT GAGGCAGGTG GATCACGAGG TCAGGAGTTC AATACCAGCC TGGCCAATAT GGTAAAACCC CATCTCTACT 019920 019921 AAAACTACAA AAATTAGCCA GGCATGGTGG CGCACGCCTG TAGTCCCAGC TACTCGGGAG GCTGAGGCAG AAGAATCACT 020000 020001 TGAACCCGGG AGGTGGAGGT TACAGTGAGC CAAGATCGCG CCACTACACT CCAGCCTGGG TGACAGAGTG AGACTCCGTC 020080 020081 TCAAAAAAAC CAAAAGACTT TATCTTATTT CCTATATGTT TGTGGTTTCA GTCCTGATGT ATAATTTGAC CCTAGTTAGA 020160 020161 ATGGTTATCT GAGGAAGTGG CCTGTACGAT TTCTGCTTTT TTAAATGTGT GGCTCCCTTT CTTCATTGAT TAACGTATGA 020240 020241 TTATTTTTAT AAATGTTCCA TGGCAGTGGG AAGGGATTCT CTGTCACATT CCACATCTGG ATCAGTTCCT CCCCATTTTG 020320 020321 TTGGTCAAAT CCGATCTGCC ATATCCTGTG TAATGACAAG TGAGTTGCAT TCTCACCGTC ACTCCTGGGG TCTCTCCGCT 020400 020401 TCCCCTGAGC TGGCTCAGCA GTCTGCTCCA TGTGTTTTGA TGCAGGGTGA CCCATTGGTA TTCCCGACAC TAACGCCCCC 020480 020481 GTCTGTGGAC TGCTTGCTGC TTGGGCTTCA CTGTGTCTGG TGTTGACAGT GCAGACCTAA AGGTGTGCAC ACATGTGCAC 020560 020561 ACACACTCCG CTGTCTTCTT GTTTGCACTG GACTTAAATA TCTATGAGGG TTATTTTCAA CTGCTGAATT TGGAATGATT 020640 020641 TTTATATCTT TTCTGCTTTC TGCCCATGTA CATGTGTTTA TTTTACACTG TTGTGATTGG TAGTTACTAT GTGGGGACAC 020720 020721 AATTACTTGG GCTGAAATAA TCCACCTGTT GTGGTTGGGG TCCTCTGGGG CATTCCAGGG TGAGAGGTTG TCACTGCCAC 020800 020801 CTGGGCCATG TGGGCCGGCA CCAGCATTTT GTGGTTACGA ATTCTACAGT CACAAATATC TTTGGGCAAA TCCCCTTCTA 020880 020881 TACCTCAAGG CAGCTTTTGG TTTGCAACCC CACTGGCCAG AGGGAAGGGC CAGTCACTTG GCTCTCTCAC TGCCCTGCGC 020960 020961 CCCAGATGGT TCTAGGGCTG CTGTTTTCCC TTGGCCCTGC CAACACCACT GTTTTTACTT CTGCTCATTG GCTGAGTGCA 021040 021041 GTGGTTCCTG GAAGCCAGTG GCACGTTTCC CCGCGTAGCT CGCTTATCCC ACAGCACACA CCCAAGGGTT CTGTTGCTAA 021120 021121 CACGCTGAAT TAATTCTTTG CTCATCTTAC AGAGTGTGTT TTGACTGCCC CCATTTCTGA GGCCTTGTAA GGCCAGAGCT 021200 021201 TTGTTGCTTC ATCGGCAGGT TGGGACTTAG ATGGCCGTGA ATGTTTCCTC TCTGCTGCTG CAGTAAGTAA GTGCCCGCAC 021280 021281 CATAGTGTGT TTGGAGGCTG AAGTTGAAGC GAGGCTGTGA GGGGAGATGG ACGTGTGAGG AGGGATGATG GGGCTTGAGC 021360 021361 AAAGTGGGGG AGGGGGCAAA GGCAGTTGGC CCAACACATT CCCCACCCCT TTGAGAGGTC TGAGGCCTGC AGACCTGGCT 021440 021441 CGGAGCCCAC CTGGTAGTCC TCAGACTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG TGTGTGTGTG 021520 021521 TGTGTAAAAG AGAGAAGTTG TGGAGAAATG GGGGGCTGAT TCTGCTCAGA TTCATCAGGA TGAGTAGAAG GCACCCAGCT 021600 021601 CTCACCCTGG CCTGACATGT GTGTCCCTGA GCAGGTTACA GTCCTCTCTG AGCCTCTGCT TCCCATCTGG ACCCTGCTGG 021680 021681 GCAGGGCTTC TGAGCTCCTT AGCACTAGCA GGAGGGGCTC CAGGGGCCCT CCCTCCATGG CAGCCAGGAC AGGACTCTCA 021760 021761 AATGAGGACA GCAGAGCTCG TGGGGGGCTC CCACGGACCC GCCGTGGGCC CAGGGGAGGC AGAGCCTGAG CCAACAGCAG 021840 021841 TGGTGCTGTG GACCGTGGAT CCTGAGGGTG GCCTGGGGCA AGTACCGGCT GAGGGTCCAG GTGGGCTTTG TGTACCTTTG 021920 021921 GGTCCTGGGG CCCTGGTGAC TTGGACTCCA GGTTAGAGTC AAGTGACAGG AGAAAGGCTG GTGGGGCCCT GTGCTTCCGA 022000 022001 CTTCATTTCG AGTGATGGCA GTTCCCAGGA AGGAATCCAC AGCTGACGGT GGCTGACAGA TCAGAGAATG GAAGGCGAGG 022080 022081 CAGGCGGGCG TCTGCGTGAC CTCAGGTGCT TGGGGCCCAG CAGACCCAGA GAACCATTTC CACTAGGCCA GGGTGCCGGA 022160 022161 AGTGTCCACA GGTCTTAGAT TCCCTGTTCA GATGAAAAGA TTTGTGCCTT TAATGATAAA AGTGATCTGC ATAGAGTCAA 022240 022241 AAATTCAAGC CATGGGTATA AAATGCAAGT AAAATCCCTG CCCTCACCTA TCCCACCCTA CTACACAGAG ATGTCCTCTC 022320 022321 GAGTTTCCTA GACTCACTCT GGAAATTTCT GTATACACAC AGAAGCTTGT GCCTCTGCTC GTGAAGGCAG AGGGAGGGAG 022400 022401 AGCTGAAGGG CCAGCACCTT CTCACCTGTG GGCCCCCTCA GTGCTCGGTC CCAGAGCATG CAGGACTGTG CCTCGTGTTC 022480 022481 AGTTTGCTGG TCTGACTTCA TGCTCCTTGG GCAGGATATG CATGTGCCAT GCTAGGAGAC ATGTGGATGT GAAGCTGGGG 022560 022561 GACAATGTCC CCTGGCTATG CCTTTACAAG GGAAGTAAGG AAGGTAGGAG GTGAGCCTGG GAGGGAGGGA GGGAGGCGCG 022640 022641 GAGCCGCCGC AGGTGTTTCT TTTACTGAGT GCAGCCCATG GCCGCACTCA GGTTTTGCTT TTCACCTTCC CATCTGTGAA 022720 022721 AGAGTGAGCA GGAAAAAGCA AAA |
