GCASPC
Contents
Annotated Information
Approved Symbol
GCASPC
Approved Name
gall bladder cancer associated suppressor of pyruvate carboxylase lncRNA
Synonyms
"TCONS_00011605, RP1-56L9.7-001, lnc-SOD2-1"
Chromosome
6q25.3
Disease
gallbladder cancer
Characteristics
GCASPC is a long noncoding RNA and it is located within the intron of insulin-like growth factor 2 receptor (IGF2R).[1] Subcellular fractionation analysis reveals GCASPC is mainly located in the cytoplasm of gallbladder cancer cells.[1]
Expression
Compared with the non tumor tissues, GCASPC is down-regulated in gallbladder cancer tissues.[1]
Function
Gain and loss of function studies in gallbladder cancer cells shows that GCASPC can suppresses gallbladder cancer cell proliferation.[1] GCASPC decreases the protein level and activity of PC by inhibiting its protein stability.[1]
Regulation
GCASPC can be directly targeted by miR-17-3p.[1]
Labs working on this lncRNA
- Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Institute of Biliary Tract Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, Shanghai, China.
