LINC01021

From LncRNAWiki
Revision as of 08:59, 5 August 2019 by Qianpeng Li (talk | contribs)
Jump to: navigation, search

Annotated Information

Name

Approved symbol: PURPL

Approved name: PURPL : p53 upregulated regulator of p53 levels

Previous symbols: LINC01021

Alias symbols: LOC643401, RP11-46C20.1

HGNC ID: HGNC: 48995

RefSeq ID：NR_038848

Ensembl ID: ENSG00000250337

LncBook transcript ID: HSALNT0289082

Characteristics

PURPL is a p53-dependent transcription driven by a MER61C LTR. CMS4 tumors with low PURPL expression were associated with poor patient survival[1].

Function

  • PURPL contributes to cellular survival in response to genotoxic stress by suppressing apoptosis[1].

Regulation

PURPL is activated by P53 in colorectal cancer (CRC)[1].

Diseases

Colorectal cancer (CRC)[1].

Expression

In CRC patient samples, PURPL expression positively correlated with a wild-type p53-associated gene expression signature. PURPL expression was increased in primary colorectal tumors and displayed a bimodal distribution that was particularly pronounced in the mesenchymal CMS4 consensus molecular subtype of CRCs[1].


Evolution

-

pubmed IDs

26183718, 29262524

Labs working on this lncRNA

  • Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany.

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Kaller M, Götz U, Hermeking H. Loss of p53-inducible long non-coding RNA LINC01021 increases chemosensitivity[J]. Oncotarget, 2017, 8(61): 102783.


Sequence

>gi|336391099|ref|NR_038848.1| Homo sapiens long intergenic non-protein coding RNA 1021 (LINC01021), long non-coding RNA

000001 CTGGGAATCA ATGTGTGAGG TGGTGCTATG TAGCAGGAAC CCCTCTTGCT TTGCAAATAG TTTTTTGTTT GTTTTCCTTT 000080
000081 TTGCCCAATA GAGCCCTGCT CTACTGACCC TTCAATGTGC CCGTGTGCCT AAATATTCCT GGTCGTGTGA AAAGAACCCA 000160
000161 GGTATTAGCT GAACTAAGGA GCACAATTCT GCAACATTTT GGCACCCAAA CACGGGGCTT GAGAAATGAA TGCAATTGGA 000240
000241 GAAACTGGTT GTTTTACCAG GCGTTGATTG GAAATGTGTG CTTCCCTTTA AGCAGTCAAG CTCAACTTGC AGAACTGATG 000320
000321 GGAACCCCTT GGGAAAACTG GCCTCAAATG TTTGTCTACA CAGTCCACAT ACAGGGTTCT TAACCTGCGA TGAGGGAAAC 000400
000401 TTCCCAGGGC TTGTCTGGGT ATGCCCACAG TGGACTGGAG CCCAAAATGC ACACTGGAGG AAGTGGATGG AGCCACGTGG 000480
000481 ATGTCATGCC TTATGCAGGG GAGGAGCCTG CTCTCTTCAG CTCCTGTGGT AATGTGGGAA TCGATCTGTG AGCATATTTA 000560
000561 ACTATCCGGC TATTTTGGAG ATTGAAAAAA GAAGACCTGA TTTATCATGT GCAATATCTC ACACATCTGT CATTTCTATT 000640
000641 CTACCGCAAT TCGATGGAGT CTTGTTCTGT GGTCCAGGCT AGAGGGCAGT GGCATGATCT CGGCTCACTA CAAGCTCTGC 000720
000721 CTCCCGGGTT CACGCCATTC TCCTGCCTCA GCCTCCTGAG TAGCTGGGAC TACAGGCGCC CGCCACCACG CCTGGCTAAT 000800
000801 TTTTTGTATA TTTACTAGAG ATGGCTAGTG TTAGCCAAGA TGGTCTCGAT CTCCTGACCT CGTGATCTGC CCACCTCAGC 000880
000881 CTGCCAAAGT GCTGGGATTA CTGGCGTGAG CCACCGTGCC TGGCCAGCAT CCTCTAATTA TTATTCATAG TTTGTGAATT 000960
000961 TAGGCCTACG TGAATAATAA TATAATATTT ACTATGATGT TACTATCTAC CAACCTTATT TTTCTTTTCT ATAAAATAGG 001040
001041 AGCCAAAATA ATATTTATGT CATACCTTAT GAAGTTAAAA TAAAATATAA CGAATGAGGG GCTTAAAAAA AAAAAAAAAA 001120

Predicted Small Protein

Name LINC01021_smProtein_653:817
Length 54
Molecular weight 6173.0232
Aromaticity 0.148148148148
Instability index 66.1351851852
Isoelectric point 7.82427978516
Runs 11
Runs residual 0.0410117434508
Runs probability 0.0251240545358
Amino acid sequence MESCSVVQARGQWHDLGSLQALPPGFTPFSCLSLLSSWDYRRPPPRLANFLYIY
Secondary structure LLEEEEEELLLEEELLLLLLLLLLLLLLHHHHHHLLLLLLLLLLLHHHLEEEEL
PRMN -
PiMo -
Retrieved from "https://ngdc.cncb.ac.cn/lncrnawiki1/index.php?title=LINC01021&oldid=1276058"