DLGAP1-AS2
LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2),one kind cytoplasmic long non-coding RNA,was up-regulated in glioma and was quite correlated with poor prognosis of glioma patients.
Contents
Annotated Information
Name
Approved symbol:DLGAP1-AS2
Approved name:DLGAP1 antisense RNA 2
HGNC ID:HGNC:28146
Previous names:DLGAP1 antisense RNA 2 (non-protein coding)
Alias symbols:MGC11082
RefSeq ID:NR_119377
LncBook ID:[1]
Characteristics
Please input information here.
Function
Depletion of DLGAP1-AS2 in glioma cells could inhibit cell proliferation and cell migration, and induce cell apoptosis, resulting in the suppression of the progression of glioma consequently. [1].
Regulation
LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression[2].
Yes Associated Protein 1 (YAP1) was the downstream target of DLGAP1-AS2 and DLGAP1-AS2 modulated glioma cell proliferation, migration and apoptosis via regulating YAP1[2].
Diseases
- glioma cells [3]
Labs working on this lncRNA
- Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.[2].
References
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedref - ↑ 2.0 2.1 2.2 Miao W, Li N, Gu B, Yi G, Su Z, Cheng H. LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression. J Biochem. 2020 Apr 1;167(4):411-418. doi: 10.1093/jb/mvz108.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedref2
