RCAN3AS
RCAN3AS plays an important role in regulating HUVEC proliferation independent of inflammation and angiogenesis.[1] Bidirectional transcription and selective splicing of human RCAN3AS sites are complex.[2]
Contents
Annotated Information
Name
Approved symbol:RCAN3AS
Approved name:RCAN3 antisense RNA
HGNC ID HGNC:39009
Previous name:RCAN3 antisense
Alias symbol:TCONS_00001428
RefSeq ID:NR_045408
LncBook ID:HSALNG0001716
Characteristics
RCAN3AS belongs to the human RCAN gene family.[1] RCAN3AS overlaps in part with exon 1a.[2]
Function
RCAN3AS inhibits HUVEC proliferation both basally and under VEGF or phorbol 12-myristate 13-acetate-stimulated conditions, however it does not modulate gene expression of the chosen inflammatory genes.[1] RCAN3AS 5′UTR and of the shared downstream coding sequence indicates a possible 5′UTR different use, due to a specific regulative role.[2]
Regulation
RCAN3AS inhibits inflammation by regulating calcineurin.[1]
Expression
RCAN3AS plays an important role in inhibiting HUVEC inflammation and proliferation.[1]
Diseases
Inflammation[1]
Labs working on this lncRNA
- Department of Histology, Embryology and Applied Biology, University of Bologna, Via Belmeloro 8, Bologna, Italy. silvia.canaider@unibo.it[1]
- Center for Research in Molecular Genetics (Fondazione CARISBO), Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy. federica.facchin2@unibo.it[2]
References
</references>- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Canaider S, Vettraino M, Norling LV, Spisni E, Facchin F, Cooper D, Perretti M. Human RCAN3 gene expression and cell growth in endothelial cells. Int J Mol Med. 2010 Dec;26(6):913-8. doi: 10.3892/ijmm_00000542.
- ↑ 2.0 2.1 2.2 2.3 2.4 Facchin F, Vitale L, Bianconi E, Piva F, Frabetti F, Strippoli P, Casadei R, Pelleri MC, Piovesan A, Canaider S. Complexity of bidirectional transcription and alternative splicing at human RCAN3 locus. PLoS One. 2011;6(9):e24508. doi: 10.1371/journal.pone.0024508. Epub 2011 Sep 22.
