DLGAP1-AS2
LncRNA DLGAP1 antisense RNA 2 (DLGAP1-AS2),one kind cytoplasmic long non-coding RNA,was up-regulated in glioma and was quite correlated with poor prognosis of glioma patients.
Contents
Annotated Information
Name
Approved symbol:DLGAP1-AS2
Approved name:DLGAP1 antisense RNA 2
HGNC ID:28146
Previous names:DLGAP1 antisense RNA 2 (non-protein coding)
Alias symbols:MGC11082
RefSeq ID:NR_119377
LncBook ID:[1]
Characteristics
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Function
Depletion of DLGAP1-AS2 in glioma cells could inhibit cell proliferation and cell migration, and induce cell apoptosis, resulting in the suppression of the progression of glioma consequently. [1].
Regulation
LncRNA DLGAP1-AS2 modulates glioma development by up-regulating YAP1 expression[1].
Yes Associated Protein 1 (YAP1) was the downstream target of DLGAP1-AS2 and DLGAP1-AS2 modulated glioma cell proliferation, migration and apoptosis via regulating YAP1[1].
Diseases
- glioma cells [1]
Labs working on this lncRNA
- Department of Neurosurgery, Zhongda Hospital, Southeast University, 87 DingJiaQiao Road, Gulou District, Nanjing, Jiangsu 210009, China.[1].
