Difference between revisions of "LIVAR"
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LIVAR:liver cell viability associated lncRNA. | LIVAR:liver cell viability associated lncRNA. | ||
| − | lnc18q22.2<ref name="ref1" /> | + | RP11-484N16.1 <ref name="ref1" /> |
| + | |||
| + | lnc18q22.2 <ref name="ref1" /> | ||
===Characteristics=== | ===Characteristics=== | ||
| − | The | + | The length of lnc18q22.2 transcript is estimated to be 633 bp <ref name="ref1" />. |
===Cellular Localization=== | ===Cellular Localization=== | ||
| − | Lnc18q22.2 is mainly present in | + | Lnc18q22.2 is mainly present in cytoplasm <ref name="ref1" />. |
===Function=== | ===Function=== | ||
[[File:Lnc18q22.2.JPG|right|thumb|400px|'''Association of lnc18q22.2 expression with different degrees of NASH'''<ref name="ref1" />.]] | [[File:Lnc18q22.2.JPG|right|thumb|400px|'''Association of lnc18q22.2 expression with different degrees of NASH'''<ref name="ref1" />.]] | ||
| − | Lnc18q22.2 is | + | Lnc18q22.2 is significantly associated with NASH (Nonalcoholic steatohepatiti) grade, lobular inflammation, and NAS (AFLD activity score) <ref name="ref1" />. In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis (including ASH (alcoholic steatohepatit) and NASH) <ref name="ref1" />. Knockdown of lnc18q22.2 results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells <ref name="ref1" />. |
| − | |||
===Expression=== | ===Expression=== | ||
| − | Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino)cell line HepG2 | + | Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino) cell line HepG2 <ref name="ref1" />. |
===Diseases=== | ===Diseases=== | ||
| − | Nonalcoholic steatohepatiti<ref name="ref1" /> | + | Nonalcoholic steatohepatiti <ref name="ref1" /> |
==Labs working on this lncRNA== | ==Labs working on this lncRNA== | ||
| Line 24: | Line 25: | ||
==References== | ==References== | ||
<references> | <references> | ||
| − | <ref name="ref1"> | + | <ref name="ref1">Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.</ref> |
| − | Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, | ||
| − | Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de | ||
| − | Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell | ||
| − | viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 | ||
| − | Sep;66(3):794-808. | ||
| − | </ref> | ||
</references> | </references> | ||
Latest revision as of 08:25, 29 September 2017
Contents
Annotated Information
Name
LIVAR:liver cell viability associated lncRNA.
RP11-484N16.1 [1]
lnc18q22.2 [1]
Characteristics
The length of lnc18q22.2 transcript is estimated to be 633 bp [1].
Cellular Localization
Lnc18q22.2 is mainly present in cytoplasm [1].
Function
Association of lnc18q22.2 expression with different degrees of NASH[1].
Lnc18q22.2 is significantly associated with NASH (Nonalcoholic steatohepatiti) grade, lobular inflammation, and NAS (AFLD activity score) [1]. In addition, lnc18q22.2 is also significantly associated with liver steatosis and steatohepatitis (including ASH (alcoholic steatohepatit) and NASH) [1]. Knockdown of lnc18q22.2 results in reduced growth in HepG2 and IHH cells and promoted cell death in Huh7 and Hep3B cells [1].
Expression
Lnc18q22.2 is predominantly expressed in liver tissue and in the HCC (hepatocellular carcino) cell line HepG2 [1].
Diseases
Nonalcoholic steatohepatiti [1]
Labs working on this lncRNA
- Department of Pediatrics, Molecular Genetics, University Medical Center Groningen, Groningen, The Netherlands.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Atanasovska B, Rensen SS, van der Sijde MR, Marsman G, Kumar V, Jonkers I, Withoff S, Shiri-Sverdlov R, Greve JWM, Faber KN, Moshage H, Wijmenga C, van de Sluis B, Hofker MH, Fu J. A liver-specific long noncoding RNA with a role in cell viability is elevated in human nonalcoholic steatohepatitis. Hepatology. 2017 Sep;66(3):794-808.
