Lnc-OR10H5-1:1

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Annotated Information

Transcriptomic Nomeclature

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Function

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Regulation

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Expression

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Allelic Information and Variation

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Evolution

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Labs working on this lncRNA

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References

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Basic Information

Transcript ID	lnc-OR10H5-1:1
Source	LNCipedia2.1
Same with	,
Classification	intergenic
Length	1441 nt
Genomic location	chr19+:15939770..15947051
Exon number	,
Exons	,
Genome context
Sequence	000001 TGACATTCTT CTGGACAATG AGTCCCATCA TCTCTCCACC ATGCACCTTG TGACTCCCTC CTCTGCTGAC AACAGATAAC 000080 000081 CACCTTTAAC TGTAACTTTC CACAGCCTAC CCCAGCCCTA TAAAGCTGCC CCTCTCCTAT CTCCCTTCGC TGACTCTCTT 000160 000161 TTCAGACTCA GCCCACTTGC ACCCAAGTGA ATTAACAGCC TTGTTGCTCA CACAAAGCCT GTTTAGGTGG TCTTCTATAC 000240 000241 GGACATGCTT GACACTTGGT GCCAAAATCT GGGCCAGGGG GACTCCTTCG TGAGACCGGC CCCCTGTCCT GGCCCTCATT 000320 000321 CCGTGAAGAG ATCCACCTGC GACCTCGGGT CCTCAGACCA GCCCAAGGAA CATCTCACCA ATTTCAAATC GGATCTCCTC 000400 000401 GGCTTAGTGG CTGAAGACTG ATGCTGCCCG ATCGCCTCAG AAGCCCCTTG GACCATCACA GATGCCGAGC TTCGGGTAAC 000480 000481 TCTTACGGTG GAGGATTCCC AGCCATATGA AGACACCCTA GCTGGACGAT CAGTCCTTGT CAAAAGTCTG ACCCCTCAAA 000560 000561 CTCTACAGCC TCAATGGACC AGACCCTACC CGGTCATTTA TAGCACACCA ACTGCCGTCC ATCTGCAGGA CCCTCTCCAT 000640 000641 TGGGTTCACC ATTCCAGAAT AAAGCCATGC CCATCAGACA GCCAGCTTGA TCTCTCCTCT TCCTCCTGGA AGCCACAAGA 000720 000721 TTAGGCCGAG AGCCGATCAG ACAAACAACC TACAACCCTT AAGCTCCTGG CAGCGCCCAG CCAAGGCCAT GCTTCCATGC 000800 000801 AACACTCCTT CCAAATGGCC ATCCCAGCAT GCTTCCAAGC AGGCTTCATC CGTTCCTCTG GACCCTCATC TCTTAAGACC 000880 000881 TGCCGCCTAT AAAAAGGATT ATATCTTGAG ACCCTATCCT CTAAAATTTT TTCCACACCC AAAACAAAAA ATCTCTGGGT 000960 000961 CAAAAGTCTA AAACGCTTAG GCTGGCAACC ATCAGATCCT TGCCCATGGT GTCCTCAAGC CTACTCTCAT GAAATGGACA 001040 001041 ACAGTACACG CATATGGGGC CAGTTCCACA TATTTGGCAA CCAGACCAGC ATCCAGGACA ACACAAAGTA TGTTGTTTGT 001120 001121 TGTTAGAGGG CTTGGGACAT TTCACTCTTT GCCAGCCTCA GCTTAATCCA GGAGACAAAG ATTATTTTCC TTATTATCTC 001200 001201 TTCTGCATAG GATCTGCAAT CAGAACTATT GAACTTCTCC ATTCAGACCG CCACTCACAC CTATGGGAAA AGGGTAATGT 001280 001281 ATCATCGGCT TAGCAACAGG GAATACTATT CGTATGATGG AAAATGGGGA CAAAAGGCTT TGGTACATAA AACATTATTC 001360 001361 CTTCCTTGGC CTAAAAACTC ATCGCCACCT ACATTAAAGC TAATATGCCT GATAAAAAAA AAAAAAAAAA AAAAAAAAAA 001440 001441 A

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Annotation (From lncRNAdb)

[lnc-OR10H5-1:1]

Section	Description
ID	UCA1
Characteristics	Spliced and polyadenylated with 3 exons (Wang (2008)). Multiple isoforms (1.4kb, 2.2kb and 2.7kb). The 2.2kb isoform contains an extended final exon compared to the 1.4kb isoform while the 2.7kb isoform has not been characterised (Wang (2006), Tsang (2007), Wang (2008)). Sequence is mainly repeat elements. Initiates in an LTR, exons sample pieces of a HERV-H element and longer 2.2kb isoform contains a second LTR at the 3' end (Wang (2006)).
Expression	Widely expressed in embryonic development (Wang (2008)) and placenta (Wang (2006)). Low or no expression in normal adult tissue but highly upregulated in cell lines resistant to drug induced apoptotic cell death and bladder, colon and lung cancer (Wang (2006), Tsang (2007)). Identified as a biomarker for bladder cancer (Wang (2006)).
Function	Functions of 1.4kb and 2.2kb isoforms have been investigated, both appear to promote and enhance tumourigenesis (Tsang (2007), Wang (2008)). Over-expression of 1.4kb isoform enhanced tumorigenic behavior of bladder cancer cells in-vitro and in-vivo. Increased drug resistance and cell motility (Wang (2008)). Overexpression of 2.2kb isoform caused resistance to drug induced apoptosis, potentially by downregulation of caspase 3 levels (Tsang (2007)). 2.2kb isoform promoted transformation in-vitro, possibly because resistance to apoptosis is an important step in tumourigenesis (Tsang (2007)).
Conservation	Found in humans. May be present in other primates but not in more distantly related mammals (Wang (2008)).
Name	Cancer up-regulated drug resistant (CUDR). Urothelial cancer associated 1 (UCA1)

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