Research and development of new technologies for preimplantation genetic diagnosis
| Title | Research and development of new technologies for preimplantation genetic diagnosis |
|---|---|
| Description | This subject conducts clinical translational research on novel preimplantation genetic testing technology. The research is divided into two parts. In the first part, the construction and clinical translation of a preimplantation genetic testing platform based on single-molecule high-throughput sequencing (third-generation sequencing) technology were carried out. This technology will also effectively evaluate the chromosomal mosaicism embryos; and build libraries separately after biopsy samples are split to reduce the incidence of allelic dropout, provide a way to solve the two major problems faced by PGT, and open up new fields of PGT development.The second part studies the clinical translation research of non-invasive preimplantation genetic testing technology based on cell-free DNA detection in embryo culture medium. The development of non-invasive embryo chromosome screening technology will revolutionize the development of embryo developmental potential detection. |
| Organism | Homo sapiens |
| Data Type | - |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA008201 |
| Release Date | 2024-04-01 |
| Submitter | YAO yuanqing (yaoyuanqing@301hospital.com.cn) |
| Organization | Chinese PLA General Hospital |
| Submission Date | 2022-03-10 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001018-99-01 | Clinicaltrial Samples | 1002 | others | 409.75 KB | zip | 0 | Controlled |
| OMIX001018-99-02 | Standarddized sampleing method samples | 201 | others | 91.03 KB | zip | 0 | Controlled |
| OMIX001018-99-03 | NICS results assess samples | 1037 | others | 46.87 KB | zip | 0 | Controlled |
| OMIX001018-99-04 | Assess cotamination sequecing samples | 178 | others | 23.16 KB | zip | 0 | Controlled |
| OMIX001018-50-05 | Assess cotamination samples arraydata | 393 | DNA Microarray | 9.38 GB | zip | 0 | Controlled |