The peripheral blood microbiome analysis via NIPT reveals the complexity of circulating microbial cell-free DNA baselines
| Title | The peripheral blood microbiome analysis via NIPT reveals the complexity of circulating microbial cell-free DNA baselines |
|---|---|
| Description | Here we utilized the standard low-pass whole genome sequencing-based NIPT to establish the microbial cfDNA baseline in health people. Totally 107,763 sequencing data from pregnant women peripheral blood samples who underwent NIPT screening were collected and re-analyzed for microbiome DNA screening. Overall and regional abundance patterns were illustrated, and normal baselines for individual microorganism were estimated and evaluated together with model parameters potentially useful for other sequencing schemes. The unique inter-species and symbiosis relationship was also established with regional features. It was found that the prevalence of major viruses showed great diversity in different regions. To sum up, our study revealed the complexity of circulating microbial cfDNA baselines, and the interpretation of microbial cfDNA sequencing results should be performed in a more comprehensive manner. |
| Organism | human blood metagenome |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA008591 |
| Release Date | 2022-05-15 |
| Submitter | Yang Du (yangdu@annoroad.com) |
| Organization | Annoroad Gene Technology |
| Submission Date | 2022-03-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001022-99-01 | CountMatrix.gz | 1 | others | 8.6 MB | gz | 0 |