Lineage Reprogramming of Fibroblasts into Functional Neurons and Hepatocytes via Chemically Induced XEN-like State
| Title | Lineage Reprogramming of Fibroblasts into Functional Neurons and Hepatocytes via Chemically Induced XEN-like State |
|---|---|
| Description | Direct lineage reprogramming has emerged as a promising approach for generating desired cell types. We found that chemically induced XEN-like cells can be induced during chemical induction of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here, we show that these chemically induced XEN-like cells can also be induced to directly reprogram into functional hepatocytes and neurons, bypassing the pluripotent state. |
| Organism | Mus musculus |
| Data Type | Transcriptomic |
| Data Accessibility | Open-access |
| BioProject | PRJCA008621 |
| Release Date | 2023-12-16 |
| Submitter | Hongkui Deng (hongkui_deng@pku.edu.cn) |
| Organization | Peking University |
| Submission Date | 2022-03-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001026-20-01 | Hepatic_cell_seq01.xls | 1 | Transcriptomic | 9.0 MB | xls | 0 | |
| OMIX001026-20-02 | Neuronal_cell_seq01.xls | 1 | Transcriptomic | 6.1 MB | xls | 0 | |
| OMIX001026-20-03 | Neuronal_cell_seq02.xls | 1 | Transcriptomic | 3.7 MB | xls | 0 | |
| OMIX001026-20-04 | Neuronal_cell_seq03.xls | 1 | Transcriptomic | 6.5 MB | xls | 0 | |
| OMIX001026-20-05 | P24_XEN_derived_CiNs.xls | 1 | Transcriptomic | 6.1 MB | xls | 0 |