Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype
| Title | Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype |
|---|---|
| Description | Analysis on genetic data confirmed common features of GBM, including gain of chr.7 and loss of chr.10, loss of critical tumor suppressors, high frequency of PDGFA and EGFR amplification. Through profiling DNA methylome of individual tumor foci, we found that promoter methylation status of genes involved in detection of chemical stimulus, immune response, and Hippo/YAP1 pathway was significantly changed in mGBM. |
| Organism | Homo |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA005262 |
| Release Date | 2022-04-14 |
| Submitter | Xiuwu Bian (bianxiuwuoffice@163.com) |
| Organization | military |
| Submission Date | 2022-04-13 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001084-06-01 | Dataset 1 | 1 | Genotype | 618.8 KB | xlsx | 0 | |
| OMIX001084-06-02 | Dataset 2 | 1 | Genotype | 4.0 MB | xlsx | 0 | |
| OMIX001084-06-03 | Dataset 3 | 1 | Genotype | 10.5 MB | xlsx | 0 | |
| OMIX001084-06-04 | Dataset 4 | 1 | Genotype | 3.4 MB | xlsx | 0 | |
| OMIX001084-06-05 | Dataset 5 | 1 | Genotype | 1.8 MB | xlsx | 0 | |
| OMIX001084-06-06 | Table S1 - S19 | 1 | Genotype | 1.1 MB | xlsx | 0 |