OMIX

Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype

OMIX001084

1Summary
Title Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype
Description Analysis on genetic data confirmed common features of GBM, including gain of chr.7 and loss of chr.10, loss of critical tumor suppressors, high frequency of PDGFA and EGFR amplification. Through profiling DNA methylome of individual tumor foci, we found that promoter methylation status of genes involved in detection of chemical stimulus, immune response, and Hippo/YAP1 pathway was significantly changed in mGBM.
Organism Homo
Data Type -
Data Accessibility Open-access
BioProject PRJCA005262
Release Date 2022-04-14
Submitter Xiuwu Bian (bianxiuwuoffice@163.com)
Organization military
Submission Date 2022-04-13
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download Times Download
OMIX001084-06-01 Dataset 1 1 Genotype 618.8 KB xlsx 0
OMIX001084-06-02 Dataset 2 1 Genotype 4.0 MB xlsx 0
OMIX001084-06-03 Dataset 3 1 Genotype 10.5 MB xlsx 0
OMIX001084-06-04 Dataset 4 1 Genotype 3.4 MB xlsx 0
OMIX001084-06-05 Dataset 5 1 Genotype 1.8 MB xlsx 0
OMIX001084-06-06 Table S1 - S19 1 Genotype 1.1 MB xlsx 0

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