Single-cell sequencing reveals the effects of hyperbaric oxygen therapy on the cellular components of tumor microenvironment in of a mouse colon cancer homologous xenografts model in mice
| Title | Single-cell sequencing reveals the effects of hyperbaric oxygen therapy on the cellular components of tumor microenvironment in of a mouse colon cancer homologous xenografts model in mice |
|---|---|
| Description | Solid tumors cancers have complex cellular components in the tumor microenvironments. , in which Hypoxia hypoxia playsis an important feature of the solid tumor microenvironment, an important role. Indeed, hypoxia which may lead s to heterogeneity of cells in different spatial locations and create creates an environment for tumors that is pro--proliferative and pro-migratory environment thatbut lacks an immune response.Here, we established aused a mouse model of MC38 colon cancer cell homologous transplantation to explore the underlying cellular mechanisms and treated withinduced by hyperbaric oxygenHBO therapy. We performed single-cell sequencing to comprehensively assess the We described a transcriptome landscape of MC38 colon cancer under hyperbaric oxygenHBO conditions therapy by advanced ScRNA-seq technology. |
| Organism | Mus musculus |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA010335 |
| Release Date | 2022-07-02 |
| Submitter | siyu xia (syxbestmayer@whu.edu.cn) |
| Organization | Jinan University |
| Submission Date | 2022-07-01 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001279-01 | H3_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-02 | H3_barcodes | 1 | Expression Profiling by NGS | 62.2 KB | tsv | 0 | |
| OMIX001279-03 | H3_matrix | 1 | Expression Profiling by NGS | 160.09 MB | matrix.mtx | 0 | |
| OMIX001279-04 | H1_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-05 | H1_barcodes | 1 | Expression Profiling by NGS | 51.92 KB | tsv | 0 | |
| OMIX001279-06 | H1_matrix | 1 | Expression Profiling by NGS | 131.2 MB | matrix.mtx | 0 | |
| OMIX001279-07 | H2_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-08 | H2_barcodes | 1 | Expression Profiling by NGS | 49.4 KB | tsv | 0 | |
| OMIX001279-09 | H2_matrix | 1 | Expression Profiling by NGS | 127.81 MB | matrix.mtx | 0 | |
| OMIX001279-10 | C3_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-11 | C3_barcodes | 1 | Expression Profiling by NGS | 40.8 KB | tsv | 0 | |
| OMIX001279-12 | C3_matrix | 1 | Expression Profiling by NGS | 116.5 MB | matrix.mtx | 0 | |
| OMIX001279-13 | C1_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-14 | C1_barcodes | 1 | Expression Profiling by NGS | 66.62 KB | tsv | 0 | |
| OMIX001279-15 | C1_matrix | 1 | Expression Profiling by NGS | 146.61 MB | matrix.mtx | 0 | |
| OMIX001279-16 | C2_features | 1 | Expression Profiling by NGS | 284.08 KB | tsv | 0 | |
| OMIX001279-17 | C2_barcodes | 1 | Expression Profiling by NGS | 53.75 KB | tsv | 0 | |
| OMIX001279-18 | C2_matrix | 1 | Expression Profiling by NGS | 137.58 MB | matrix.mtx | 0 |