OMIX

Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites

OMIX001886

1Summary
Title Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Description CTCF, a conserved 3D genome architecture protein, determines proper genome-wide chromatin looping interactions through directional binding to specific sequence elements of four modules within numerous CTCF-binding sites (CBSs) by its 11 zinc fingers (ZFs). We report four crystal structures of human CTCF in complex with CBSs of the protocadherin (Pcdh) clusters.CTCF and DNA complex structures provide important insights into the molecular mechanisms for the directionality, diversity, flexibility, dynamics, and conservation of multivalent CTCF binding to its cognate sites across the entire human genome.
Organism DNA-binding vector pODB80
Data Type Protein 3D Structure Data
Data Accessibility Open-access
BioProject PRJCA011997
Release Date 2022-09-27
Submitter Yunran Zhan (yunranzhan@ibp.ac.cn)
Organization Institute of Biophysics Chinese Academy of Sciences
Submission Date 2022-09-20
2Files & Download

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OMIX001886-01 CTCF-DNA complexes 4 Protein 3D Structure Data 865.7 KB zip 0

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