Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
| Title | Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites |
|---|---|
| Description | CTCF, a conserved 3D genome architecture protein, determines proper genome-wide chromatin looping interactions through directional binding to specific sequence elements of four modules within numerous CTCF-binding sites (CBSs) by its 11 zinc fingers (ZFs). We report four crystal structures of human CTCF in complex with CBSs of the protocadherin (Pcdh) clusters.CTCF and DNA complex structures provide important insights into the molecular mechanisms for the directionality, diversity, flexibility, dynamics, and conservation of multivalent CTCF binding to its cognate sites across the entire human genome. |
| Organism | DNA-binding vector pODB80 |
| Data Type | Protein 3D Structure Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA011997 |
| Release Date | 2022-09-27 |
| Submitter | Yunran Zhan (yunranzhan@ibp.ac.cn) |
| Organization | Institute of Biophysics Chinese Academy of Sciences |
| Submission Date | 2022-09-20 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX001886-01 | CTCF-DNA complexes | 4 | Protein 3D Structure Data | 865.7 KB | zip | 0 |