| Title | Single-cell analysis reveals cellular heterogeneity and novel therapeutic targets in relapsed/refractory AML |
|---|---|
| Description | To explore the intratumoral heterogeneity and identify potential therapeutic targets for RR-AML, we performed scRNA-seq on bone marrow specimens from seven AML patients who were short-term relapsed or primary refractory after cytarabine-based chemotherapy. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA005787 |
| Release Date | 2022-10-24 |
| Submitter | Wang Qianghu (wangqh@njmu.edu.cn) |
| Organization | Nanjing Medical University |
| Submission Date | 2022-10-24 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX002180-01 | scRNA matrix of Pt#1 | 1 | Expression Profiling | 44.28 MB | tar | Unavailable |
| OMIX002180-02 | scRNA matrix of diagnostic Pt#10 | 1 | Expression Profiling | 135.82 MB | tar | Unavailable |
| OMIX002180-03 | scRNA matrix of Pt#10 after treatment | 1 | Expression Profiling | 69.68 MB | tar | Unavailable |
| OMIX002180-04 | scRNA matrix of Pt#2 | 1 | Expression Profiling | 41.11 MB | tar | Unavailable |
| OMIX002180-05 | scRNA matrix of diagnostic Pt#3 | 1 | Expression Profiling | 111.35 MB | tar | Unavailable |
| OMIX002180-06 | scRNA matrix of Pt#3 after treatment | 1 | Expression Profiling | 85.84 MB | tar | Unavailable |
| OMIX002180-07 | scRNA matrix of Pt#4 | 1 | Expression Profiling | 57.63 MB | tar | Unavailable |
| OMIX002180-08 | scRNA matrix of Pt#5 | 1 | Expression Profiling | 32.11 MB | tar | Unavailable |
| OMIX002180-09 | scRNA matrix of Pt#6 | 1 | Expression Profiling | 142.62 MB | tar | Unavailable |
| OMIX002180-10 | scRNA matrix of Pt#7 | 1 | Expression Profiling | 32.9 MB | tar | Unavailable |
| OMIX002180-11 | scRNA matrix of Pt#8 | 1 | Expression Profiling | 59.7 MB | tar | Unavailable |
| OMIX002180-12 | scRNA matrix of diagnostic Pt#9 | 1 | Expression Profiling | 61.9 MB | tar | Unavailable |
| OMIX002180-13 | scRNA matrix of Pt#9 after treatment | 1 | Expression Profiling | 89.02 MB | tar | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed/refractory acute myeloid leukemia | Leukemia | 2022-12 | OMIX002180 | Deposit |
| Single-cell transcriptome analysis defines novel molecular subtypes and reveals therapeutic implications of T/myeloid mixed-phenotype acute leukemia | Genome Medicine | 2025-11 | OMIX006728 OMIX005014 OMIX002180 | Deposit |
| Identification of cell surface markers for acute myeloid leukemia prognosis based on multi-model analysis | Journal of Biomedical Research | 2024-05 | OMIX002180 | Deposit |