Proteogenomics landscape of Acute Myeloid Leukemia
| Title | Proteogenomics landscape of Acute Myeloid Leukemia |
|---|---|
| Description | Acute myeloid leukemia (AML) is a malignant hematological cancer with the worst prognosis of all leukemia categories. Here, we reported a comprehensive proteogenomic analysis of 101 Chinese AML patients, including proteomic, phosphoproteomic analysis and an ex vivo drug sensitivity analysis in addition to Whole exome and transcriptome sequencing. We explored the impact of genomic alterations on proteomic and phosphoproteomic characterizations, and also uncovered the protein and phosphosite panel as prognostic indicators. Proteome-based unsupervised clustering revealed three subtypes with different molecular characterizations and clinical outcomes. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA012927 |
| Release Date | 2023-08-12 |
| Submitter | Jia Li (jli@simm.ac.cn) |
| Organization | Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
| Submission Date | 2022-11-14 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002335-01 | AMLG2 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.58 GB | zip | 0 | Controlled |
| OMIX002335-02 | AMLG1 | 24 | Proteomic Data by Mass Spectrometry (MS) | 23.04 GB | zip | 0 | Controlled |
| OMIX002335-03 | PHO-AML-G12 | 12 | Proteomic Data by Mass Spectrometry (MS) | 11.76 GB | zip | 0 | Controlled |
| OMIX002335-04 | PHO-AML-G11 | 12 | Proteomic Data by Mass Spectrometry (MS) | 11.82 GB | zip | 0 | Controlled |
| OMIX002335-05 | PHO-AML-G9 | 12 | Proteomic Data by Mass Spectrometry (MS) | 11.45 GB | zip | 0 | Controlled |
| OMIX002335-06 | PHO-AML-G10 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.01 GB | zip | 0 | Controlled |
| OMIX002335-07 | PHO-AML-G8 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.77 GB | zip | 0 | Controlled |
| OMIX002335-08 | PHO-AML-G7 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.58 GB | zip | 0 | Controlled |
| OMIX002335-09 | PHO-AML-G5 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.2 GB | zip | 0 | Controlled |
| OMIX002335-10 | PHO-AML-G6 | 12 | Proteomic Data by Mass Spectrometry (MS) | 11.82 GB | zip | 0 | Controlled |
| OMIX002335-11 | AMLG4 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.83 GB | zip | 0 | Controlled |
| OMIX002335-12 | AMLG5 | 24 | Proteomic Data by Mass Spectrometry (MS) | 23.19 GB | zip | 0 | Controlled |
| OMIX002335-13 | AMLG3 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.02 GB | zip | 0 | Controlled |
| OMIX002335-14 | PHO-AML-G4 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.19 GB | zip | 0 | Controlled |
| OMIX002335-15 | PHO-AML-G3 | 12 | Proteomic Data by Mass Spectrometry (MS) | 13.51 GB | zip | 0 | Controlled |
| OMIX002335-16 | AMLG9 | 24 | Proteomic Data by Mass Spectrometry (MS) | 26.16 GB | zip | 0 | Controlled |
| OMIX002335-17 | AMLG8 | 24 | Proteomic Data by Mass Spectrometry (MS) | 25.17 GB | zip | 0 | Controlled |
| OMIX002335-18 | AMLG7 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.77 GB | zip | 0 | Controlled |
| OMIX002335-19 | AMLG12 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.8 GB | zip | 0 | Controlled |
| OMIX002335-20 | AMLG11 | 24 | Proteomic Data by Mass Spectrometry (MS) | 22.57 GB | zip | 0 | Controlled |
| OMIX002335-21 | AMLG10 | 24 | Proteomic Data by Mass Spectrometry (MS) | 24.13 GB | zip | 0 | Controlled |
| OMIX002335-22 | PHO-AML-G1 | 12 | Proteomic Data by Mass Spectrometry (MS) | 13.16 GB | zip | 0 | Controlled |
| OMIX002335-23 | PHO-AML-G2 | 12 | Proteomic Data by Mass Spectrometry (MS) | 12.86 GB | zip | 0 | Controlled |
| OMIX002335-24 | AMLG6 | 24 | Proteomic Data by Mass Spectrometry (MS) | 21.87 GB | zip | 0 | Controlled |