| Title | Single-cell RNA sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer |
|---|---|
| Description | Radiochemotherapy (RCT) is a powerful treatment for cervical cancer, which affects not only malignant cells but also the immune and stromal compartments of the tumor. Understanding the remodeling of the local ecosystem induced by RCT would provide valuable insights into improving treatment strategies for cervical cancer. In this study, we applied single-cell RNA sequencing to paired pre- and post-RCT tumor biopsies from patients with cervical cancer and adjacent normal cervical tissues. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA011382 |
| Release Date | 2026-06-24 |
| Submitter | Chao Liu (charles.liu@whu.edu.cn) |
| Organization | Peking University First Hospital |
| Submission Date | 2022-12-02 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX002494-01 | human_Serum | 8 | Expression Profiling | 115.57 MB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Single-cell RNA-sequencing reveals radiochemotherapy-induced innate immune activation and MHC-II upregulation in cervical cancer | Signal Transduction and Targeted Therapy | 2023-01 | OMIX002494 OMIX001005 | Deposit Secondary use |
| Integrated system for screening tumor-specific TCRs, epitopes, and HLA subtypes using single-cell sequencing data | Journal for Immunotherapy of Cancer | 2025-07 | OMIX002494 | Secondary use |