Plasma Landscape of Proteins and Metabolites in Acute Promyelocytic Leukemia: Metabolome
| Title | Plasma Landscape of Proteins and Metabolites in Acute Promyelocytic Leukemia: Metabolome |
|---|---|
| Description | The treatment of acute promyelocytic leukemia (APL) with ATRA/ATO has been recognized as a model for translational medicine research. Here we reported a cross-sectional correlation network framework that was successfully applied to interpret multi-layered datasets of paired plasma samples from APL patients before or after ATRA/ATO induction therapy. Our study identified an untreated APL plasma network, revealing two prominent features: one characterized by altered secretory protein and metabolite profiles, indicative of heightened proliferative and energy consumption states of APL blasts; the other featuring APL plasma-enriched proteins, catalyzing the metabolism of plasma metabolites that were potential trans-regulatory targets of PML/RARA, suggesting a possible involvement of APL blasts in modulating their plasma microenvironment. This work sheds new light into the pathophysiology and treatment of APL and provides an information-rich reference data cohort for exploratory study of leukemia microenvironment. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA013709 |
| Release Date | 2023-08-12 |
| Submitter | Niu Qiao (qn12425@rjh.com.cn) |
| Organization | Ruijin Hospital, Shanghai jiaotong University School of Medicine |
| Submission Date | 2022-12-06 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002538-01 | POS_QC.45s.zip | 45 | Metabolome Data by Mass Spectrometry (MS) | 2.5 GB | zip | 0 | |
| OMIX002538-02 | NEG_QC.45s.zip | 45 | Metabolome Data by Mass Spectrometry (MS) | 2.62 GB | zip | 0 | |
| OMIX002538-03 | POS_HC.106s.zip | 106 | Metabolome Data by Mass Spectrometry (MS) | 5.8 GB | zip | 0 | |
| OMIX002538-04 | NEG_HC.106s.zip | 106 | Metabolome Data by Mass Spectrometry (MS) | 6.05 GB | zip | 0 | |
| OMIX002538-05 | POS_DX.169s.zip | 169 | Metabolome Data by Mass Spectrometry (MS) | 9.31 GB | zip | 0 | |
| OMIX002538-06 | NEG_DX.169s.zip | 169 | Metabolome Data by Mass Spectrometry (MS) | 9.82 GB | zip | 0 | |
| OMIX002538-07 | POS_CR.169s.zip | 169 | Metabolome Data by Mass Spectrometry (MS) | 9.31 GB | zip | 0 | |
| OMIX002538-08 | NEG_CR.169s.zip | 169 | Metabolome Data by Mass Spectrometry (MS) | 9.81 GB | zip | 0 | |
| OMIX002538-09 | meta_matrix_log2.PeakArea_489s.xlsx | 489 | Metabolome Data by Mass Spectrometry (MS) | 2.68 MB | xls | 0 |