OMIX002605

1Summary

Title	A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Description	Exercise is generally considered to have beneficial effects on the body, including improving tissue homeostasis, promoting regeneration, and improving disease resistance. But this effect has not been studied at multi-tissue, single-cell resolution, nor has it been carefully examined in young and old individuals. In order to systematically study the effects of exercise on multiple tissues and organs of the body, especially the effects on neural, immune, vascular, and stem cells, we performed aerobic exercise in young and old mice, and evaluated in detail at the single-cell level the changes in cell composition and gene expression of 14 different tissues and organs including brain, heart, muscle, liver, and kidney. We also treated exercised and non-exercise mice with the pro-inflammatory bacterial lipopolysaccharide, aiming to reveal the effect of exercise on pro-inflammatory injuries at single cell resolution.
Organism	Mus musculus
Data Type	Expression Profiling by Array
Data Accessibility	Open-access
BioProject	PRJCA009794
Release Date	2023-01-06
Submitter	Guanghui Liu (ghliu@ioz.ac.cn)
Organization	Institute of Zoology, Chinese Academy of Sciences
Submission Date	2022-12-14

2Files & Download

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File ID	File Title	Number/Samples	File Type	File Size	File Suffix	Download
OMIX002605-01	OC-LPS-Liver-sn	1	Expression Profiling by Array	30.15 MB	tar	FTP HTTPs
OMIX002605-02	OC-Muscle	1	Expression Profiling by Array	45.16 MB	tar	FTP HTTPs
OMIX002605-03	YC-Lung	1	Expression Profiling by Array	68.55 MB	tar	FTP HTTPs
OMIX002605-04	YC-SC	1	Expression Profiling by Array	59.21 MB	tar	FTP HTTPs
OMIX002605-05	YE-Aorta-sn	1	Expression Profiling by Array	44.86 MB	tar	FTP HTTPs
OMIX002605-06	YC-Liver	1	Expression Profiling by Array	62.07 MB	tar	FTP HTTPs
OMIX002605-07	YE-Aorta	1	Expression Profiling by Array	84.8 MB	tar	FTP HTTPs
OMIX002605-08	YC-LPS-Lung	1	Expression Profiling by Array	87.58 MB	tar	FTP HTTPs
OMIX002605-09	YC-Heart	1	Expression Profiling by Array	42.44 MB	tar	FTP HTTPs
OMIX002605-10	YC-Brain	1	Expression Profiling by Array	34.49 MB	tar	FTP HTTPs
OMIX002605-11	YE-Heart	1	Expression Profiling by Array	48.67 MB	tar	FTP HTTPs
OMIX002605-12	OC-BM	1	Expression Profiling by Array	73.81 MB	tar	FTP HTTPs
OMIX002605-13	OC-Cerebellum	1	Expression Profiling by Array	38.62 MB	tar	FTP HTTPs
OMIX002605-14	YC-Aorta	1	Expression Profiling by Array	62.58 MB	tar	FTP HTTPs
OMIX002605-15	OE-Muscle	1	Expression Profiling by Array	42.76 MB	tar	FTP HTTPs
OMIX002605-16	OE-LPS-Aorta-sn	1	Expression Profiling by Array	33.81 MB	tar	FTP HTTPs
OMIX002605-17	OE-Intestine	1	Expression Profiling by Array	67.27 MB	tar	FTP HTTPs
OMIX002605-18	OE-Kidney	1	Expression Profiling by Array	104.54 MB	tar	FTP HTTPs
OMIX002605-19	YC-Blood	1	Expression Profiling by Array	40.15 MB	tar	FTP HTTPs
OMIX002605-20	YE-Brain	1	Expression Profiling by Array	38.4 MB	tar	FTP HTTPs
OMIX002605-21	OE-Heart	1	Expression Profiling by Array	54.16 MB	tar	FTP HTTPs
OMIX002605-22	YC-Muscle	1	Expression Profiling by Array	49.78 MB	tar	FTP HTTPs
OMIX002605-23	YE-Muscle	1	Expression Profiling by Array	50.21 MB	tar	FTP HTTPs
OMIX002605-24	YE-BM	1	Expression Profiling by Array	78.2 MB	tar	FTP HTTPs
OMIX002605-25	YC-Cerebellum	1	Expression Profiling by Array	38.4 MB	tar	FTP HTTPs
OMIX002605-26	OC-LPS-BM	1	Expression Profiling by Array	82.76 MB	tar	FTP HTTPs
OMIX002605-27	OC-Liver-sn	1	Expression Profiling by Array	25.05 MB	tar	FTP HTTPs
OMIX002605-28	OE-Liver-sn	1	Expression Profiling by Array	7.62 MB	tar	FTP HTTPs
OMIX002605-29	YC-LPS-Blood	1	Expression Profiling by Array	76.31 MB	tar	FTP HTTPs
OMIX002605-30	OE-Aorta-sn	1	Expression Profiling by Array	25.61 MB	tar	FTP HTTPs
OMIX002605-31	YC-Intestine	1	Expression Profiling by Array	51.81 MB	tar	FTP HTTPs
OMIX002605-32	YC-Kidney	1	Expression Profiling by Array	49.15 MB	tar	FTP HTTPs
OMIX002605-33	OE-Blood	1	Expression Profiling by Array	39.05 MB	tar	FTP HTTPs
OMIX002605-34	OE-BM	1	Expression Profiling by Array	59.97 MB	tar	FTP HTTPs
OMIX002605-35	OE-Spleen	1	Expression Profiling by Array	67.41 MB	tar	FTP HTTPs
OMIX002605-36	YE-LPS-Aorta-sn	1	Expression Profiling by Array	19.53 MB	tar	FTP HTTPs
OMIX002605-37	OE-Aorta	1	Expression Profiling by Array	93.47 MB	tar	FTP HTTPs
OMIX002605-38	YE-LPS-Blood	1	Expression Profiling by Array	60.65 MB	tar	FTP HTTPs
OMIX002605-39	YC-Aorta-sn	1	Expression Profiling by Array	27.75 MB	tar	FTP HTTPs
OMIX002605-40	YE-Cerebellum	1	Expression Profiling by Array	34.88 MB	tar	FTP HTTPs
OMIX002605-41	YE-Liver-sn	1	Expression Profiling by Array	21.5 MB	tar	FTP HTTPs
OMIX002605-42	OC-Kidney	1	Expression Profiling by Array	130.94 MB	tar	FTP HTTPs
OMIX002605-43	OC-Brain	1	Expression Profiling by Array	40.81 MB	tar	FTP HTTPs
OMIX002605-44	YC-BM	1	Expression Profiling by Array	67.3 MB	tar	FTP HTTPs
OMIX002605-45	YE-Spleen	1	Expression Profiling by Array	64.47 MB	tar	FTP HTTPs
OMIX002605-46	YE-SC	1	Expression Profiling by Array	61.73 MB	tar	FTP HTTPs
OMIX002605-47	OC-SC	1	Expression Profiling by Array	50.39 MB	tar	FTP HTTPs
OMIX002605-48	YE-LPS-Lung	1	Expression Profiling by Array	110.19 MB	tar	FTP HTTPs
OMIX002605-49	YE-Intestine	1	Expression Profiling by Array	72.72 MB	tar	FTP HTTPs
OMIX002605-50	OE-LPS-BM	1	Expression Profiling by Array	96.33 MB	tar	FTP HTTPs
OMIX002605-51	OC-Testis	1	Expression Profiling by Array	72.3 MB	tar	FTP HTTPs
OMIX002605-52	YE-Liver	1	Expression Profiling by Array	98.91 MB	tar	FTP HTTPs
OMIX002605-53	OE-LPS-Liver-sn	1	Expression Profiling by Array	28.26 MB	tar	FTP HTTPs
OMIX002605-54	OE-Brain	1	Expression Profiling by Array	23.36 MB	tar	FTP HTTPs
OMIX002605-55	OC-LPS-Aorta-sn	1	Expression Profiling by Array	19.12 MB	tar	FTP HTTPs
OMIX002605-56	YE-LPS-BM	1	Expression Profiling by Array	87.24 MB	tar	FTP HTTPs
OMIX002605-57	OE-LPS-Lung	1	Expression Profiling by Array	110.75 MB	tar	FTP HTTPs
OMIX002605-58	OC-LPS-Blood	1	Expression Profiling by Array	58.98 MB	tar	FTP HTTPs
OMIX002605-59	OC-Aorta-sn	1	Expression Profiling by Array	28.99 MB	tar	FTP HTTPs
OMIX002605-60	OC-Liver	1	Expression Profiling by Array	91.12 MB	tar	FTP HTTPs
OMIX002605-61	OC-Aorta	1	Expression Profiling by Array	234.95 MB	tar	FTP HTTPs
OMIX002605-62	YE-Testis	1	Expression Profiling by Array	87.58 MB	tar	FTP HTTPs
OMIX002605-63	YE-LPS-Liver-sn	1	Expression Profiling by Array	30.15 MB	tar	FTP HTTPs
OMIX002605-64	OC-Spleen	1	Expression Profiling by Array	57.31 MB	tar	FTP HTTPs
OMIX002605-65	YE-Lung	1	Expression Profiling by Array	79.07 MB	tar	FTP HTTPs
OMIX002605-66	YC-LPS-Aorta-sn	1	Expression Profiling by Array	19.95 MB	tar	FTP HTTPs
OMIX002605-67	OE-Cerebellum	1	Expression Profiling by Array	36.58 MB	tar	FTP HTTPs
OMIX002605-68	OC-LPS-Lung	1	Expression Profiling by Array	61.12 MB	tar	FTP HTTPs
OMIX002605-69	OC-Heart	1	Expression Profiling by Array	46.75 MB	tar	FTP HTTPs
OMIX002605-70	OE-LPS-Blood	1	Expression Profiling by Array	76.48 MB	tar	FTP HTTPs
OMIX002605-71	OE-Testis	1	Expression Profiling by Array	46.74 MB	tar	FTP HTTPs
OMIX002605-72	OC-Lung	1	Expression Profiling by Array	83.51 MB	tar	FTP HTTPs
OMIX002605-73	YC-Spleen	1	Expression Profiling by Array	41.86 MB	tar	FTP HTTPs
OMIX002605-74	OC-Intestine	1	Expression Profiling by Array	73.59 MB	tar	FTP HTTPs
OMIX002605-75	YE-Blood	1	Expression Profiling by Array	63.44 MB	tar	FTP HTTPs
OMIX002605-76	YC-LPS-Liver-sn	1	Expression Profiling by Array	15.26 MB	tar	FTP HTTPs
OMIX002605-77	OE-Lung	1	Expression Profiling by Array	68.57 MB	tar	FTP HTTPs
OMIX002605-78	OC-Blood	1	Expression Profiling by Array	49.47 MB	tar	FTP HTTPs
OMIX002605-79	YC-Liver-sn	1	Expression Profiling by Array	21.99 MB	tar	FTP HTTPs
OMIX002605-80	YC-LPS-BM	1	Expression Profiling by Array	77.41 MB	tar	FTP HTTPs
OMIX002605-81	YC-Testis	1	Expression Profiling by Array	53.63 MB	tar	FTP HTTPs
OMIX002605-82	YE-Kidney	1	Expression Profiling by Array	198.38 MB	tar	FTP HTTPs
OMIX002605-83	OE-SC	1	Expression Profiling by Array	65.22 MB	tar	FTP HTTPs
OMIX002605-84	OE-Liver	1	Expression Profiling by Array	102.2 MB	tar	FTP HTTPs

3Relevant Publications

Paper Title	Journal Name	Publish Time	Accession	Citing Type
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body	The Innovation	2023-01	OMIX002605	Deposit

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