A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
| Title | A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body |
|---|---|
| Description | Exercise is generally considered to have beneficial effects on the body, including improving tissue homeostasis, promoting regeneration, and improving disease resistance. But this effect has not been studied at multi-tissue, single-cell resolution, nor has it been carefully examined in young and old individuals. In order to systematically study the effects of exercise on multiple tissues and organs of the body, especially the effects on neural, immune, vascular, and stem cells, we performed aerobic exercise in young and old mice, and evaluated in detail at the single-cell level the changes in cell composition and gene expression of 14 different tissues and organs including brain, heart, muscle, liver, and kidney. We also treated exercised and non-exercise mice with the pro-inflammatory bacterial lipopolysaccharide, aiming to reveal the effect of exercise on pro-inflammatory injuries at single cell resolution. |
| Organism | Mus musculus |
| Data Type | Expression Profiling by Array |
| Data Accessibility | Open-access |
| BioProject | PRJCA009794 |
| Release Date | 2023-01-06 |
| Submitter | Guanghui Liu (ghliu@ioz.ac.cn) |
| Organization | Institute of Zoology, Chinese Academy of Sciences |
| Submission Date | 2022-12-14 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002605-01 | OC-LPS-Liver-sn | 1 | Expression Profiling by Array | 30.15 MB | tar | 0 | |
| OMIX002605-02 | OC-Muscle | 1 | Expression Profiling by Array | 45.16 MB | tar | 0 | |
| OMIX002605-03 | YC-Lung | 1 | Expression Profiling by Array | 68.55 MB | tar | 0 | |
| OMIX002605-04 | YC-SC | 1 | Expression Profiling by Array | 59.21 MB | tar | 0 | |
| OMIX002605-05 | YE-Aorta-sn | 1 | Expression Profiling by Array | 44.86 MB | tar | 0 | |
| OMIX002605-06 | YC-Liver | 1 | Expression Profiling by Array | 62.07 MB | tar | 0 | |
| OMIX002605-07 | YE-Aorta | 1 | Expression Profiling by Array | 84.8 MB | tar | 0 | |
| OMIX002605-08 | YC-LPS-Lung | 1 | Expression Profiling by Array | 87.58 MB | tar | 0 | |
| OMIX002605-09 | YC-Heart | 1 | Expression Profiling by Array | 42.44 MB | tar | 0 | |
| OMIX002605-10 | YC-Brain | 1 | Expression Profiling by Array | 34.49 MB | tar | 0 | |
| OMIX002605-11 | YE-Heart | 1 | Expression Profiling by Array | 48.67 MB | tar | 0 | |
| OMIX002605-12 | OC-BM | 1 | Expression Profiling by Array | 73.81 MB | tar | 0 | |
| OMIX002605-13 | OC-Cerebellum | 1 | Expression Profiling by Array | 38.62 MB | tar | 0 | |
| OMIX002605-14 | YC-Aorta | 1 | Expression Profiling by Array | 62.58 MB | tar | 0 | |
| OMIX002605-15 | OE-Muscle | 1 | Expression Profiling by Array | 42.76 MB | tar | 0 | |
| OMIX002605-16 | OE-LPS-Aorta-sn | 1 | Expression Profiling by Array | 33.81 MB | tar | 0 | |
| OMIX002605-17 | OE-Intestine | 1 | Expression Profiling by Array | 67.27 MB | tar | 0 | |
| OMIX002605-18 | OE-Kidney | 1 | Expression Profiling by Array | 104.54 MB | tar | 0 | |
| OMIX002605-19 | YC-Blood | 1 | Expression Profiling by Array | 40.15 MB | tar | 0 | |
| OMIX002605-20 | YE-Brain | 1 | Expression Profiling by Array | 38.4 MB | tar | 0 | |
| OMIX002605-21 | OE-Heart | 1 | Expression Profiling by Array | 54.16 MB | tar | 0 | |
| OMIX002605-22 | YC-Muscle | 1 | Expression Profiling by Array | 49.78 MB | tar | 0 | |
| OMIX002605-23 | YE-Muscle | 1 | Expression Profiling by Array | 50.21 MB | tar | 0 | |
| OMIX002605-24 | YE-BM | 1 | Expression Profiling by Array | 78.2 MB | tar | 0 | |
| OMIX002605-25 | YC-Cerebellum | 1 | Expression Profiling by Array | 38.4 MB | tar | 0 | |
| OMIX002605-26 | OC-LPS-BM | 1 | Expression Profiling by Array | 82.76 MB | tar | 0 | |
| OMIX002605-27 | OC-Liver-sn | 1 | Expression Profiling by Array | 25.05 MB | tar | 0 | |
| OMIX002605-28 | OE-Liver-sn | 1 | Expression Profiling by Array | 7.62 MB | tar | 0 | |
| OMIX002605-29 | YC-LPS-Blood | 1 | Expression Profiling by Array | 76.31 MB | tar | 0 | |
| OMIX002605-30 | OE-Aorta-sn | 1 | Expression Profiling by Array | 25.61 MB | tar | 0 | |
| OMIX002605-31 | YC-Intestine | 1 | Expression Profiling by Array | 51.81 MB | tar | 0 | |
| OMIX002605-32 | YC-Kidney | 1 | Expression Profiling by Array | 49.15 MB | tar | 0 | |
| OMIX002605-33 | OE-Blood | 1 | Expression Profiling by Array | 39.05 MB | tar | 0 | |
| OMIX002605-34 | OE-BM | 1 | Expression Profiling by Array | 59.97 MB | tar | 0 | |
| OMIX002605-35 | OE-Spleen | 1 | Expression Profiling by Array | 67.41 MB | tar | 0 | |
| OMIX002605-36 | YE-LPS-Aorta-sn | 1 | Expression Profiling by Array | 19.53 MB | tar | 0 | |
| OMIX002605-37 | OE-Aorta | 1 | Expression Profiling by Array | 93.47 MB | tar | 0 | |
| OMIX002605-38 | YE-LPS-Blood | 1 | Expression Profiling by Array | 60.65 MB | tar | 0 | |
| OMIX002605-39 | YC-Aorta-sn | 1 | Expression Profiling by Array | 27.75 MB | tar | 0 | |
| OMIX002605-40 | YE-Cerebellum | 1 | Expression Profiling by Array | 34.88 MB | tar | 0 | |
| OMIX002605-41 | YE-Liver-sn | 1 | Expression Profiling by Array | 21.5 MB | tar | 0 | |
| OMIX002605-42 | OC-Kidney | 1 | Expression Profiling by Array | 130.94 MB | tar | 0 | |
| OMIX002605-43 | OC-Brain | 1 | Expression Profiling by Array | 40.81 MB | tar | 0 | |
| OMIX002605-44 | YC-BM | 1 | Expression Profiling by Array | 67.3 MB | tar | 0 | |
| OMIX002605-45 | YE-Spleen | 1 | Expression Profiling by Array | 64.47 MB | tar | 0 | |
| OMIX002605-46 | YE-SC | 1 | Expression Profiling by Array | 61.73 MB | tar | 0 | |
| OMIX002605-47 | OC-SC | 1 | Expression Profiling by Array | 50.39 MB | tar | 0 | |
| OMIX002605-48 | YE-LPS-Lung | 1 | Expression Profiling by Array | 110.19 MB | tar | 0 | |
| OMIX002605-49 | YE-Intestine | 1 | Expression Profiling by Array | 72.72 MB | tar | 0 | |
| OMIX002605-50 | OE-LPS-BM | 1 | Expression Profiling by Array | 96.33 MB | tar | 0 | |
| OMIX002605-51 | OC-Testis | 1 | Expression Profiling by Array | 72.3 MB | tar | 0 | |
| OMIX002605-52 | YE-Liver | 1 | Expression Profiling by Array | 98.91 MB | tar | 0 | |
| OMIX002605-53 | OE-LPS-Liver-sn | 1 | Expression Profiling by Array | 28.26 MB | tar | 0 | |
| OMIX002605-54 | OE-Brain | 1 | Expression Profiling by Array | 23.36 MB | tar | 0 | |
| OMIX002605-55 | OC-LPS-Aorta-sn | 1 | Expression Profiling by Array | 19.12 MB | tar | 0 | |
| OMIX002605-56 | YE-LPS-BM | 1 | Expression Profiling by Array | 87.24 MB | tar | 0 | |
| OMIX002605-57 | OE-LPS-Lung | 1 | Expression Profiling by Array | 110.75 MB | tar | 0 | |
| OMIX002605-58 | OC-LPS-Blood | 1 | Expression Profiling by Array | 58.98 MB | tar | 0 | |
| OMIX002605-59 | OC-Aorta-sn | 1 | Expression Profiling by Array | 28.99 MB | tar | 0 | |
| OMIX002605-60 | OC-Liver | 1 | Expression Profiling by Array | 91.12 MB | tar | 0 | |
| OMIX002605-61 | OC-Aorta | 1 | Expression Profiling by Array | 234.95 MB | tar | 0 | |
| OMIX002605-62 | YE-Testis | 1 | Expression Profiling by Array | 87.58 MB | tar | 0 | |
| OMIX002605-63 | YE-LPS-Liver-sn | 1 | Expression Profiling by Array | 30.15 MB | tar | 0 | |
| OMIX002605-64 | OC-Spleen | 1 | Expression Profiling by Array | 57.31 MB | tar | 0 | |
| OMIX002605-65 | YE-Lung | 1 | Expression Profiling by Array | 79.07 MB | tar | 0 | |
| OMIX002605-66 | YC-LPS-Aorta-sn | 1 | Expression Profiling by Array | 19.95 MB | tar | 0 | |
| OMIX002605-67 | OE-Cerebellum | 1 | Expression Profiling by Array | 36.58 MB | tar | 0 | |
| OMIX002605-68 | OC-LPS-Lung | 1 | Expression Profiling by Array | 61.12 MB | tar | 0 | |
| OMIX002605-69 | OC-Heart | 1 | Expression Profiling by Array | 46.75 MB | tar | 0 | |
| OMIX002605-70 | OE-LPS-Blood | 1 | Expression Profiling by Array | 76.48 MB | tar | 0 | |
| OMIX002605-71 | OE-Testis | 1 | Expression Profiling by Array | 46.74 MB | tar | 0 | |
| OMIX002605-72 | OC-Lung | 1 | Expression Profiling by Array | 83.51 MB | tar | 0 | |
| OMIX002605-73 | YC-Spleen | 1 | Expression Profiling by Array | 41.86 MB | tar | 0 | |
| OMIX002605-74 | OC-Intestine | 1 | Expression Profiling by Array | 73.59 MB | tar | 0 | |
| OMIX002605-75 | YE-Blood | 1 | Expression Profiling by Array | 63.44 MB | tar | 0 | |
| OMIX002605-76 | YC-LPS-Liver-sn | 1 | Expression Profiling by Array | 15.26 MB | tar | 0 | |
| OMIX002605-77 | OE-Lung | 1 | Expression Profiling by Array | 68.57 MB | tar | 0 | |
| OMIX002605-78 | OC-Blood | 1 | Expression Profiling by Array | 49.47 MB | tar | 0 | |
| OMIX002605-79 | YC-Liver-sn | 1 | Expression Profiling by Array | 21.99 MB | tar | 0 | |
| OMIX002605-80 | YC-LPS-BM | 1 | Expression Profiling by Array | 77.41 MB | tar | 0 | |
| OMIX002605-81 | YC-Testis | 1 | Expression Profiling by Array | 53.63 MB | tar | 0 | |
| OMIX002605-82 | YE-Kidney | 1 | Expression Profiling by Array | 198.38 MB | tar | 0 | |
| OMIX002605-83 | OE-SC | 1 | Expression Profiling by Array | 65.22 MB | tar | 0 | |
| OMIX002605-84 | OE-Liver | 1 | Expression Profiling by Array | 102.2 MB | tar | 0 |