Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus
| Title | Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus |
|---|---|
| Description | This was a longitudinal case-control study. Cerebrospinal fluids in 37 iNPH patients and 16 age-balanced controls was collected from September 2020 to March 2022, and analyzed using a mass spectrometry-based proteomics workflow. Clinical evaluation was performed on all iNPH patients, and 32 patients underwent ventriculoperitoneal shunting. Postoperative CSF was also collected from 10 iNPH patients who underwent shunting surgery. Bioinformatics analysis and the random forest model were performed to identify CSF proteome changes and predictors of clinical outcome. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA014889 |
| Release Date | 2023-10-01 |
| Submitter | Junming Zhu (dr.zhujunming@zju.edu.cn) |
| Organization | The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date | 2023-02-11 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX002958-01 | proteomic data | 1 | Proteomic Data by Mass Spectrometry (MS) | 1.2 MB | xlsx | 0 | |
| OMIX002958-02 | characteristic data | 1 | Proteomic Data by Mass Spectrometry (MS) | 17.5 KB | xlsx | 0 |