Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer
| Title | Spermine Is a Natural Suppressor of AR Signaling in Castration-Resistant Prostate Cancer |
|---|---|
| Description | We demonstrate spermine as an anti-cancer metabolite by inhibiting PRMT1 to transcriptionally inhibit AR-FL and AR-V7 signaling in CRPC, and indicate spermine and PRMT1 inhibition as powerful strategies overcoming limitations of current AR-based therapies in CRPC. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA015535 |
| Release Date | 2023-06-07 |
| Submitter | dong gao (dong.gao@sibcb.ac.cn) |
| Organization | Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences |
| Submission Date | 2023-03-15 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003328-01 | RNA_raw_count_matrix | 1 | Expression Profiling by NGS | 2.7 MB | csv | 0 | Unavailable |