The structures of homotetrameric GluK2 in complex with NETO2
| Title | The structures of homotetrameric GluK2 in complex with NETO2 |
|---|---|
| Description | In this dataset, we report cryo-electron microscopy structures of homotetrameric GluK2 in complex with NETO2 at inhibited and desensitized states, illustrating variable stoichiometry of GluK2-NETO2 complexes, with one or two NETO2 subunits associating with GluK2.We find that NETO2 accesses only two broad faces of kainate receptors, intermolecularly crosslinking the lower lobe of ATDA/C, the upper lobe of LBDB/D and the lower lobe of LBDA/C, illustrating how NETO2 regulates receptor-gating kinetics.This dataset contains five structures: 7F57 (Kainate-bound GluK2-1xNeto2 complex, at the desensitized state); 7F56(DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD);7F59(DNQX-bound GluK2-1xNeto2 complex);7F5A (DNQX-bound GluK2-2xNeto2 complex); 7F5B(LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex). |
| Organism | Homo sapiens |
| Data Type | Protein 3D Structure Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA015643 |
| Release Date | 2023-03-22 |
| Submitter | Yanli Dong (dongyl@ibp.ac.cn) |
| Organization | Institute of Biophysics, Chinese Academy of Sciences |
| Submission Date | 2023-03-21 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003412-01 | Kainate-bound GluK2-1xNeto2 complex, at the desensitized state | 1 | Protein 3D Structure Data | 34.6 MB | zip | 0 | |
| OMIX003412-02 | DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD | 1 | Protein 3D Structure Data | 34.5 MB | zip | 0 | |
| OMIX003412-03 | DNQX-bound GluK2-1xNeto2 complex | 1 | Protein 3D Structure Data | 34.5 MB | zip | 0 | |
| OMIX003412-04 | DNQX-bound GluK2-2xNeto2 complex | 1 | Protein 3D Structure Data | 34.2 MB | zip | 0 | |
| OMIX003412-05 | LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex | 1 | Protein 3D Structure Data | 34.4 MB | zip | 0 |