| Title |
The cryo-EM structures of the human CaV2.2 complex in apo, ziconotide-bound, and two CaV2.2-specific pore blockers-bound states |
| Description |
In this dataset, we report a cryo-electron microscopy (cryo-EM) structure of the human CaV2.2 complex in apo, ziconotide-bound, and two CaV2.2-specific pore blockers-bound states. This structure reveals the molecular basis for the unique inactivation process of CaV2.2 channels, in which the intracellular gate formed by S6 helices is closed and a W-helix from the domain II-III linker stabilizes closed-state inactivation. This dataset contains four structures: 7VFW (Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1);7VFS(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state);7VFU(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide);7VFV(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212). |
| Organism |
Homo sapiens |
| Data Type |
Protein 3D Structure Data |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA015643 |
| Release Date |
2023-03-22 |
| Submitter |
Yanli Dong (dongyl@ibp.ac.cn) |
| Organization |
Institute of Biophysics, Chinese Academy of Sciences |
| Submission Date |
2023-03-21 |