The cryo-EM structures of the human CaV2.2 complex in apo, ziconotide-bound, and two CaV2.2-specific pore blockers-bound states
| Title | The cryo-EM structures of the human CaV2.2 complex in apo, ziconotide-bound, and two CaV2.2-specific pore blockers-bound states |
|---|---|
| Description | In this dataset, we report a cryo-electron microscopy (cryo-EM) structure of the human CaV2.2 complex in apo, ziconotide-bound, and two CaV2.2-specific pore blockers-bound states. This structure reveals the molecular basis for the unique inactivation process of CaV2.2 channels, in which the intracellular gate formed by S6 helices is closed and a W-helix from the domain II-III linker stabilizes closed-state inactivation. This dataset contains four structures: 7VFW (Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1);7VFS(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state);7VFU(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide);7VFV(Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212). |
| Organism | Homo sapiens |
| Data Type | Protein 3D Structure Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA015643 |
| Release Date | 2023-03-22 |
| Submitter | Yanli Dong (dongyl@ibp.ac.cn) |
| Organization | Institute of Biophysics, Chinese Academy of Sciences |
| Submission Date | 2023-03-21 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003414-01 | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to CaV2.2-blocker1 | 1 | Protein 3D Structure Data | 118.2 MB | zip | 0 | |
| OMIX003414-02 | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, apo state | 1 | Protein 3D Structure Data | 230.7 MB | zip | 0 | |
| OMIX003414-03 | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to ziconotide | 1 | Protein 3D Structure Data | 118.5 MB | zip | 0 | |
| OMIX003414-04 | Human N-type voltage gated calcium channel CaV2.2-alpha2/delta1-beta1 complex, bound to PD173212 | 1 | Protein 3D Structure Data | 118.3 MB | zip | 0 |