The structures of the human T-type CaV3.3 channel, in the absence and presence of antihypertensive drug mibefradil, antispasmodic drug otilonium bromide and antipsychotic drug pimozide
| Title | The structures of the human T-type CaV3.3 channel, in the absence and presence of antihypertensive drug mibefradil, antispasmodic drug otilonium bromide and antipsychotic drug pimozide |
|---|---|
| Description | In this dataset, we determine structures of the human T-type CaV3.3 channel, in the absence and presence of antihypertensive drug mibefradil, antispasmodic drug otilonium bromide and antipsychotic drug pimozide. CaV3.3 contains a long bended S6 helix from domain III, with a positive charged region protruding into the cytosol, which is critical for T-type CaV channel activation at low voltage. This dataset contains four structures: 7WLL(CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ)); 7WLK (CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB)); 7WLI (CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo)); 7WLJ (CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB)). |
| Organism | Homo sapiens |
| Data Type | Protein 3D Structure Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA015643 |
| Release Date | 2023-03-22 |
| Submitter | Yanli Dong (dongyl@ibp.ac.cn) |
| Organization | Institute of Biophysics, Chinese Academy of Sciences |
| Submission Date | 2023-03-21 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003416-01 | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with pimozide(PMZ) | 1 | Protein 3D Structure Data | 60.0 MB | zip | 0 | |
| OMIX003416-02 | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with Otilonium Bromide(OB) | 1 | Protein 3D Structure Data | 1.7 MB | zip | 0 | |
| OMIX003416-03 | CryoEM structure of human low-voltage activated T-type calcium channel CaV3.3 (apo) | 1 | Protein 3D Structure Data | 59.7 MB | zip | 0 | |
| OMIX003416-04 | CryoEM structure of human low-voltage activated T-type calcium channel Cav3.3 in complex with mibefradil (MIB) | 1 | Protein 3D Structure Data | 59.8 MB | zip | 0 |