Spatial Multiomics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC
| Title | Spatial Multiomics Reveals the Heterogeneity of Tumor Microenvironment in the OSF-Associated OSCC |
|---|---|
| Description | Oral submucous fibrosis (OSF) is one of the most common precancerous malignant lesions (PML) with high rates exacerbating into oral squamous cell carcinoma (OSCC), mostly occurred in patients with chewing betel-nut habits in Southeast Asia and Pacific region. However, the spatial characteristics and heteogeneities of tumor microenvironment (TME) in OSF-associated OSCC still remains unclear. Here. we characterized the spatiotemporal changes of OSF-associated OSCC at different malignant states by performing 10x Visium Spatial Transcriptomics (ST) sequencing and airflow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) analysis. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA015936 |
| Release Date | 2024-02-02 |
| Submitter | Wei Xiong (xiongwei@csu.edu.cn) |
| Organization | Central South University |
| Submission Date | 2023-03-30 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003566-01 | Patient 1 | 4 | Metabolome Data by Mass Spectrometry (MS) | 262.93 MB | zip | 0 | Controlled |
| OMIX003566-02 | Patient 2 | 4 | Metabolome Data by Mass Spectrometry (MS) | 295.57 MB | zip | 0 | Controlled |
| OMIX003566-03 | Patient 3 | 4 | Metabolome Data by Mass Spectrometry (MS) | 330.95 MB | zip | 0 | Controlled |
| OMIX003566-04 | Patient 4 | 4 | Metabolome Data by Mass Spectrometry (MS) | 339.48 MB | zip | 0 | Controlled |