| Title | Single-cell and spatial transcriptomic profiling of human glioblastomas |
|---|---|
| Description | This deposition includes scRNA-seq and Spatial Transcriptomics data for 24 GBM patients, which are categorized as follows: a) 7 patients with newly diagnosed GBM (ND group) b) 5 patients with recurrent GBM (Rec group) c) 12 patients who have undergone neoadjuvant therapy (Neo group). Additionally, this deposition contains scRNA-seq data for both wild-type (WT) and SiglecE knockout (KO) mice bearing intracranial CT2A glioma. The provided data includes both the raw matrix and the processed Seurat objects. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA015974 |
| Release Date | 2023-06-28 |
| Submitter | Guangshuai Jia (guangshuaijia@icloud.com) |
| Organization | Guangzhou Medical University |
| Submission Date | 2023-03-31 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX003593-01 | Processed Seurat object for mouse scRNA-seq data | 1 | Expression Profiling | 585.07 MB | rds | Unavailable |
| OMIX003593-02 | Raw matrix for Spatial Transcriptomics | 20 | Expression Profiling | 554.57 MB | zip | Unavailable |
| OMIX003593-03 | Processed Seurat object for ST data | 1 | Expression Profiling | 4.15 GB | rds | Unavailable |
| OMIX003593-04 | Processed Seurat object for scRNA-seq data | 1 | Expression Profiling | 5.78 GB | rds | Unavailable |
| OMIX003593-06 | Raw matrix for mouse scRNA-seq data | 2 | Expression Profiling | 222.85 MB | zip | Unavailable |
| OMIX003593-07 | Raw matrix for scRNA-seq data | 24 | Expression Profiling | 1.1 GB | zip | Unavailable |
| OMIX003593-08 | bulkRNAseq_count_table | 1 | Expression Profiling | 4.0 MB | zip | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response | Nature Cancer | 2023-07 | OMIX003593 | Deposit |
| Spatial-reprogramming derived GPNMB+ macrophages interact with COL6A3+ fibroblasts to enhance vascular fibrosis in glioblastoma | Genome Medicine | 2025-10 | OMIX003593 | Deposit |