Metabolome of Epinephrine-treated or untreated M.tb
| Title | Metabolome of Epinephrine-treated or untreated M.tb |
|---|---|
| Description | Human stress hormones have been studied as a source of communication among human micro biota and their hosts. Therefore, we hypothesized thatHowever, whether M. tuberculosis would also sense and response to certain types of human stress hormones remain elusive. Here we screened human catecholamin stress hormones against M. tuberculosis and checked their effects on the bacteria. Our results showed that epinephrine significantly stimulated the growth of M. tuberculosis in serum-based medium as well as macrophages. In silico analysis and molecular docking results suggested that the senser part of the mprB might be the putative adrenergic sensor. Further study showed that epinephrine significantly enhances M. tuberculosis biofilm formation, which with distinct textures and compositions and is resistant to antibiotics. Together these results demonstrated that epinephrine stimulates the growth and biofilm formation of M. tuberculosis. |
| Organism | Mycobacterium tuberculosis H37Ra |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA015999 |
| Release Date | 2024-01-04 |
| Submitter | Xiaojian Cao (Stargazer@webmail.hzau.edu.cn) |
| Organization | Huazhong Agricultural University |
| Submission Date | 2023-04-01 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003595-01 | Raw results | 1 | Metabolome Data by Mass Spectrometry (MS) | 26.24 KB | xlsx | 0 | |
| OMIX003595-02 | Positive assay of Epinephrine-treat-3 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 90 MB | raw | 0 | |
| OMIX003595-03 | Positive assay of Epinephrine-treat-2 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 88.56 MB | raw | 0 | |
| OMIX003595-04 | Positive assay of Epinephrine-treat-1 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 85.07 MB | raw | 0 | |
| OMIX003595-05 | Positive assay of Control-3 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 89.98 MB | raw | 0 | |
| OMIX003595-06 | Positive assay of Control-2 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 86.48 MB | raw | 0 | |
| OMIX003595-07 | Positive assay of Control-1 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 86.31 MB | raw | 0 | |
| OMIX003595-08 | Negative assay of Epinephrine-treat-3 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.91 MB | raw | 0 | |
| OMIX003595-09 | Negative assay of Epinephrine-treat-2 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.51 MB | raw | 0 | |
| OMIX003595-10 | Negative assay of Epinephrine-treat-1 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.36 MB | raw | 0 | |
| OMIX003595-11 | Negative assay of Control-3 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.55 MB | raw | 0 | |
| OMIX003595-12 | Negative assay of Control-2 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.76 MB | raw | 0 | |
| OMIX003595-13 | Negative assay of Control-1 sample | 1 | Metabolome Data by Mass Spectrometry (MS) | 64.72 MB | raw | 0 |