| Title | Single cell RNA sequencing of patients with Richter's syndrome |
|---|---|
| Description | One CLL patient was diagnosed with CLL and received treatment with fludarabine, cyclophosphamide, and rituximab regimens. Three years later, he was diagnosed with RS. To dissect the precise molecular mechanism of RS, and to identify clonal architecture and candidate driver genes of RS, we performed high-throughput RNA sequencing at the single-cell level. Paired samples of peripheral blood mononuclear cells and the Richter transformed lymphonodus tissue of the patient were analyzed for cell type-specific transcriptional changes by single-cell RNA-seq (scRNA-seq). |
| Organism | Homo sapiens |
| Data Type | Expression Profiling |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA015982 |
| Release Date | 2024-12-31 |
| Submitter | Hongling Peng (penghongling@csu.edu.cn) |
| Organization | The Second Xiangya Hospital, Central South University |
| Submission Date | 2023-04-13 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX003727-01 | the expression matrix of the CLL patient | 1 | Expression Profiling | 87.79 MB | tar | Unavailable |
| OMIX003727-02 | the expression matrix of the Richter syndrome patient | 1 | Expression Profiling | 66.59 MB | tar | Unavailable |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Clonal architecture and single-cell transcriptome landscape in Richter's syndrome | British Journal of Haematology | 2023-06 | OMIX003727 | Deposit |