Gene regulatory innovations underlying human neocortical diversification
| Title | Gene regulatory innovations underlying human neocortical diversification |
|---|---|
| Description | To explore the cellular diversity and spatial organization of adult human neocortical areas, we conducted spatial transcriptomie and single-nucleus multiome analysis (snATAC-seq and snRNA-seq from the same cell) on the dorsolateral prefrontal cortex (dlPFC), the primary visual cortex (V1C), the primary motor cortex (M1C), and the anterior cingulate cortex (ACC). Joint analysis of snATAC-seq and snRNA-seq further revealed the regulatory mechanisms underlying human neocortical area specification and its evolution. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA020002 |
| Release Date | 2023-11-01 |
| Submitter | Ying Zhu (ying_zhu@fudan.edu.cn) |
| Organization | Fudan University |
| Submission Date | 2023-04-14 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003750-01 | Single-nucleus multiome (RNA + ATAC) data from four human neocortical areas | 1 | Expression Profiling by NGS | 8.04 GB | rds | 0 | Unavailable |
| OMIX003750-02 | Spatial transcriptome data from male human anterior cingulate cortex | 1 | Expression Profiling by NGS | 218.81 MB | h5ad | 0 | Unavailable |
| OMIX003750-03 | Spatial transcriptome data from male human dorsolateral prefrontal cortex | 1 | Expression Profiling by NGS | 243.91 MB | h5ad | 0 | Unavailable |
| OMIX003750-04 | Spatial transcriptome data from male human primary motor cortex | 1 | Expression Profiling by NGS | 150.05 MB | h5ad | 0 | Unavailable |
| OMIX003750-05 | Spatial transcriptome data from male human primary visual cortex | 1 | Expression Profiling by NGS | 156.8 MB | h5ad | 0 | Unavailable |
| OMIX003750-06 | Spatial transcriptome data from female human anterior cingulate cortex | 1 | Expression Profiling by NGS | 162.3 MB | h5ad | 0 | Unavailable |
| OMIX003750-07 | Spatial transcriptome data from female human dorsolateral prefrontal cortex | 1 | Expression Profiling by NGS | 174.94 MB | h5ad | 0 | Unavailable |
| OMIX003750-08 | Spatial transcriptome data from female human primary motor cortex | 1 | Expression Profiling by NGS | 160.23 MB | h5ad | 0 | Unavailable |
| OMIX003750-09 | Spatial transcriptome data from female human primary visual cortex | 1 | Expression Profiling by NGS | 163.73 MB | h5ad | 0 | Unavailable |
| OMIX003750-10 | Single-nucleus transcriptome data of transposable elements from four human neocortical areas | 1 | Expression Profiling by NGS | 3.55 GB | rds | 0 | Unavailable |