| Title |
Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders |
| Description |
In this study, high-throughput T-cell receptor (TCR) sequencing was performed on peripheral blood from 151 pre-treatment AQP4-IgG+ NMOSD patients and 151 healthy individuals. We compared the TCR repertoire of NMOSD and healthy individuals and to identify TCR clones that were significantly enriched in NMOSD. In addition, we treated 28 AQP4-IgG+ NMOSD patients with immunosuppressants and followed them for 6 months to compare changes in NMOSD-specific TCRs (NMOSD-TCRs) before and after treatment. |
| Organism |
Homo sapiens |
| Data Type |
Other Type of Genomic Data |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA013167 |
| Release Date |
2023-09-13 |
| Submitter |
Hong-yu Zhou (zhouhy@scu.edu.cn) |
| Organization |
West China Hospital of Sichuan University |
| Submission Date |
2023-05-09 |