Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders
| Title | Immune repertoire profiling reveals its clinical application potential and triggers for Neuromyelitis Optica Spectrum Disorders |
|---|---|
| Description | In this study, high-throughput T-cell receptor (TCR) sequencing was performed on peripheral blood from 151 pre-treatment AQP4-IgG+ NMOSD patients and 151 healthy individuals. We compared the TCR repertoire of NMOSD and healthy individuals and to identify TCR clones that were significantly enriched in NMOSD. In addition, we treated 28 AQP4-IgG+ NMOSD patients with immunosuppressants and followed them for 6 months to compare changes in NMOSD-specific TCRs (NMOSD-TCRs) before and after treatment. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA013167 |
| Release Date | 2023-09-13 |
| Submitter | Hong-yu Zhou (zhouhy@scu.edu.cn) |
| Organization | West China Hospital of Sichuan University |
| Submission Date | 2023-05-09 |
The data cannot be downloaded as it has not yet been registered in the Human Genetic Resource Management Platform of MOST.
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX003989-01 | Clinical information of NMOSD patients and healthy individuals | 332 | Other Type of Genomic Data | 30.01 KB | xlsx | 0 | Unavailable |
| OMIX003989-02 | Processed TCR repertoire sequencing data of NMOSD patients and healthy individuals | 332 | Other Type of Genomic Data | 174.49 MB | bz2 | 0 | Unavailable |