A Cytological Atlas of the Human Liver Proteome from PROTEOMESKY-LIVERHu 2.0, a Publicly Available Database
| Title | A Cytological Atlas of the Human Liver Proteome from PROTEOMESKY-LIVERHu 2.0, a Publicly Available Database |
|---|---|
| Description | We establish a cell type-resolved healthy human liver proteome including hepatocytes (HCs), hepatic stellate cells (HSCs), Kupffer cells (KCs), and liver sinusoidal endothelial cells (LSECs) by high-resolution mass spectrometry. We quantify total 8354 proteins for four cell types and over 6000 proteins for each cell type.Human liver cells show some novel molecular features: HCs maintain KCs and LSECs homeostasis by producing cholesterol and ketone bodies; HSCs participate in xenobiotics metabolism as an agent deliverer; KCs and LSECs mediate immune response through MHC class 2-TLRs and MHC class 1-TGFBeta cascade, respectively; and KCs play a central role in diurnal rhythms regulation through sensing diurnal IGF and temperature flux. Together, this work expands our understandings of liver physiology and provides a useful resource for future analyses of normal and diseased livers. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA017467 |
| Release Date | 2023-06-07 |
| Submitter | PUMIN ZHANG (pzhangbcm@zju.edu.cn) |
| Organization | Beijing Proteome Research Center |
| Submission Date | 2023-06-06 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004291-01 | 2 | 6 | Proteomic Data by Mass Spectrometry (MS) | 5.1 GB | zip | 0 | |
| OMIX004291-02 | 5 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.32 GB | zip | 0 | |
| OMIX004291-03 | 8 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.33 GB | zip | 0 | |
| OMIX004291-04 | 20 | 6 | Proteomic Data by Mass Spectrometry (MS) | 6 GB | zip | 0 | |
| OMIX004291-05 | 21 | 6 | Proteomic Data by Mass Spectrometry (MS) | 6.66 GB | zip | 0 | |
| OMIX004291-06 | 22 | 4 | Proteomic Data by Mass Spectrometry (MS) | 4.21 GB | zip | 0 | |
| OMIX004291-07 | 1 | 6 | Proteomic Data by Mass Spectrometry (MS) | 5.19 GB | zip | 0 | |
| OMIX004291-08 | 4 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.91 GB | zip | 0 | |
| OMIX004291-09 | 7 | 6 | Proteomic Data by Mass Spectrometry (MS) | 2.96 GB | zip | 0 | |
| OMIX004291-10 | 15 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.04 GB | zip | 0 | |
| OMIX004291-11 | 16 | 6 | Proteomic Data by Mass Spectrometry (MS) | 5.07 GB | zip | 0 | |
| OMIX004291-12 | 17 | 6 | Proteomic Data by Mass Spectrometry (MS) | 7.41 GB | zip | 0 | |
| OMIX004291-13 | 18 | 6 | Proteomic Data by Mass Spectrometry (MS) | 6.65 GB | zip | 0 | |
| OMIX004291-14 | 19 | 6 | Proteomic Data by Mass Spectrometry (MS) | 7.02 GB | zip | 0 | |
| OMIX004291-15 | 3 | 6 | Proteomic Data by Mass Spectrometry (MS) | 4.82 GB | zip | 0 | |
| OMIX004291-16 | 6 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.22 GB | zip | 0 | |
| OMIX004291-17 | 9 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.36 GB | zip | 0 | |
| OMIX004291-18 | 10 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.48 GB | zip | 0 | |
| OMIX004291-19 | 11 | 6 | Proteomic Data by Mass Spectrometry (MS) | 2.98 GB | zip | 0 | |
| OMIX004291-20 | 12 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.24 GB | zip | 0 | |
| OMIX004291-21 | 13 | 6 | Proteomic Data by Mass Spectrometry (MS) | 3.36 GB | zip | 0 | |
| OMIX004291-22 | 14 | 6 | Proteomic Data by Mass Spectrometry (MS) | 2.94 GB | zip | 0 |