Single-cell dissection of cellular and molecular features underlying MSCs therapy in ischemic acute kidney injury
| Title | Single-cell dissection of cellular and molecular features underlying MSCs therapy in ischemic acute kidney injury |
|---|---|
| Description | Mesenchymal stem cells (MSCs) exert beneficial therapeutic effects in acute kidney injury (AKI), while the detailed repair mechanism remains unclear. Herein, we probed the underlying mechanisms of MSC therapy in AKI by performing unbiased single-cell-RNA sequencing in IRI model with/without MSC treatment. Our analyses uncovered the tubular epithelial cells (TECs) and immune cells transcriptomic diversity and highlighted a repair trajectory involving renal stem/progenitor cell differentiation. |
| Organism | Mus musculus |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA008567 |
| Release Date | 2023-08-23 |
| Submitter | Min Zhang (mzhangcool@yeah.net) |
| Organization | the First Medical Center of PLA General Hospital |
| Submission Date | 2023-06-26 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004421-01 | IRI1d_1 | 1 | Expression Profiling by NGS | 15.74 MB | tar | 0 | |
| OMIX004421-02 | IRI3d_2 | 1 | Expression Profiling by NGS | 17.77 MB | tar | 0 | |
| OMIX004421-03 | IRI3d_3 | 1 | Expression Profiling by NGS | 20.83 MB | tar | 0 | |
| OMIX004421-04 | IRI3d_1 | 1 | Expression Profiling by NGS | 18.84 MB | tar | 0 | |
| OMIX004421-05 | sham1 | 1 | Expression Profiling by NGS | 31.89 MB | tar | 0 | |
| OMIX004421-06 | IRI1d_3 | 1 | Expression Profiling by NGS | 19.19 MB | tar | 0 | |
| OMIX004421-07 | IRI1d_2 | 1 | Expression Profiling by NGS | 32.95 MB | tar | 0 | |
| OMIX004421-08 | IRI1d_4 | 1 | Expression Profiling by NGS | 10.11 MB | tar | 0 | |
| OMIX004421-09 | IRI3d_4 | 1 | Expression Profiling by NGS | 22.39 MB | tar | 0 | |
| OMIX004421-10 | MSC1 | 1 | Expression Profiling by NGS | 22.37 MB | tar | 0 | |
| OMIX004421-11 | MSC3 | 1 | Expression Profiling by NGS | 22.19 MB | tar | 0 | |
| OMIX004421-12 | MSC2 | 1 | Expression Profiling by NGS | 15.73 MB | tar | 0 | |
| OMIX004421-13 | sham2 | 1 | Expression Profiling by NGS | 22.46 MB | tar | 0 | |
| OMIX004421-14 | Sham3 | 1 | Expression Profiling by NGS | 45.38 MB | tar | 0 |