| Title | Single-cell dissection of cellular and molecular features underlying MSCs therapy in ischemic acute kidney injury |
|---|---|
| Description | Mesenchymal stem cells (MSCs) exert beneficial therapeutic effects in acute kidney injury (AKI), while the detailed repair mechanism remains unclear. Herein, we probed the underlying mechanisms of MSC therapy in AKI by performing unbiased single-cell-RNA sequencing in IRI model with/without MSC treatment. Our analyses uncovered the tubular epithelial cells (TECs) and immune cells transcriptomic diversity and highlighted a repair trajectory involving renal stem/progenitor cell differentiation. |
| Organism | Mus musculus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA008567 |
| Release Date | 2023-08-23 |
| Submitter | Min Zhang (mzhangcool@yeah.net) |
| Organization | the First Medical Center of PLA General Hospital |
| Submission Date | 2023-06-26 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX004421-01 | IRI1d_1 | 1 | Expression Profiling | 15.74 MB | tar | |
| OMIX004421-02 | IRI3d_2 | 1 | Expression Profiling | 17.77 MB | tar | |
| OMIX004421-03 | IRI3d_3 | 1 | Expression Profiling | 20.83 MB | tar | |
| OMIX004421-04 | IRI3d_1 | 1 | Expression Profiling | 18.84 MB | tar | |
| OMIX004421-05 | sham1 | 1 | Expression Profiling | 31.89 MB | tar | |
| OMIX004421-06 | IRI1d_3 | 1 | Expression Profiling | 19.19 MB | tar | |
| OMIX004421-07 | IRI1d_2 | 1 | Expression Profiling | 32.95 MB | tar | |
| OMIX004421-08 | IRI1d_4 | 1 | Expression Profiling | 10.11 MB | tar | |
| OMIX004421-09 | IRI3d_4 | 1 | Expression Profiling | 22.39 MB | tar | |
| OMIX004421-10 | MSC1 | 1 | Expression Profiling | 22.37 MB | tar | |
| OMIX004421-11 | MSC3 | 1 | Expression Profiling | 22.19 MB | tar | |
| OMIX004421-12 | MSC2 | 1 | Expression Profiling | 15.73 MB | tar | |
| OMIX004421-13 | sham2 | 1 | Expression Profiling | 22.46 MB | tar | |
| OMIX004421-14 | Sham3 | 1 | Expression Profiling | 45.38 MB | tar |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Single-cell dissection of cellular and molecular features underlying mesenchymal stem cell therapy in ischemic acute kidney injury | Molecular Therapy | 2023-08 | OMIX004421 | Deposit |
| Injury-Induced Epithelial Spp1 Engages Cd44 to Promote Neutrophil Recruitment and Exacerbate Acute Kidney Injury | Journal of Inflammation Research | 2026-02 | OMIX004421 | Secondary use |
| Trem2 activation by renal tubular debris sustains Arg1 + macrophage survival and promotes tubular epithelial repair in renal ischemia–reperfusion injury | Frontiers in Immunology | 2026-04 | OMIX004421 | Secondary use |