Multiple ctDNA-based biomarkers of selective RET inhibition in non-small cell lung cancer patients
| Title | Multiple ctDNA-based biomarkers of selective RET inhibition in non-small cell lung cancer patients |
|---|---|
| Description | We analyzed a prospective cohort of Chinese RET fusion-positive, pralsetinib-treated advanced NSCLC patients. We examined the association between tumor response/progression and genomic aberration, baseline ctDNA level, ctDNA clearance as defined by multiple metrics, and ctDNA dynamic patterns. Paired samples at baseline and after progression were also analyzed to identify potential resistance mechanisms. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA017936 |
| Release Date | 2024-02-27 |
| Submitter | Chang Lu (luchang@gdph.org.cn) |
| Organization | Guangdong Provincial People's Hospital |
| Submission Date | 2023-06-27 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004427-01 | selective RET inhibition-mutation data | 1 | Other Type of Genomic Data | 36.0 KB | xlsx | 0 | Controlled |