Plasma metabolic signatures uncover therapeutic response and prognosis of third-generation EGFR-TKI treatment in patients with NSCLC-the proteomic data
| Title | Plasma metabolic signatures uncover therapeutic response and prognosis of third-generation EGFR-TKI treatment in patients with NSCLC-the proteomic data |
|---|---|
| Description | Advanced EGFR T790M-mutated non-small cell lung cancer (NSCLC) inevitably develops resistance to third-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. Metabolic reprogramming support EGFR-TKI resistance, while thorough metabolomics clinical studies are limited. Here, we enrolled 186 NSCLC patients from Phase I and IIa clinical studies and characterized responsive metabolic features of third-generation EGFR-TKI. Our study included locally advanced or metastatic NSCLC patients from the open-label, single-arm, phase I/IIa study of BPI-7711(NCT03386955). Tumor diagnosis was confirmed by histology or cytology, with EGFR-sensitive mutations (including Exon19Deletion, L858R, G719X, L861QandS768I). Two hundred and twenty plasma samples of 186 patients were collected in 16 hospitals (220 for metabolism,49 for WES and 14 for proteomics). |
| Organism | Homo sapiens |
| Data Type | Other Type of Proteomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA018003 |
| Release Date | 2024-07-18 |
| Submitter | Yuankai Shi (syuankaipumc@126.com) |
| Organization | National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences |
| Submission Date | 2023-06-29 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004444-03 | The raw data of sample-1 | 1 | Other Type of Proteomic Data | 1.69 GB | raw | 0 | |
| OMIX004444-04 | The raw data of sample-2 | 1 | Other Type of Proteomic Data | 1.5 GB | raw | 0 | |
| OMIX004444-05 | The raw data of sample-3 | 1 | Other Type of Proteomic Data | 1.62 GB | raw | 0 | |
| OMIX004444-05 | The raw data of sample-3 | 1 | Other Type of Proteomic Data | 1.62 GB | raw | 0 | |
| OMIX004444-07 | The raw data of sample-4 | 1 | Other Type of Proteomic Data | 1.49 GB | raw | 0 | |
| OMIX004444-08 | The raw data of sample-5 | 1 | Other Type of Proteomic Data | 1.62 GB | raw | 0 | |
| OMIX004444-09 | The raw data of sample-6 | 1 | Other Type of Proteomic Data | 1.47 GB | raw | 0 | |
| OMIX004444-10 | The raw data of sample-7 | 1 | Other Type of Proteomic Data | 1.62 GB | raw | 0 | |
| OMIX004444-11 | The raw data of sample-11 | 1 | Other Type of Proteomic Data | 1.65 GB | raw | 0 | |
| OMIX004444-12 | The raw data of sample-12 | 1 | Other Type of Proteomic Data | 1.64 GB | raw | 0 | |
| OMIX004444-13 | The raw data of sample-14 | 1 | Other Type of Proteomic Data | 1.61 GB | raw | 0 | |
| OMIX004444-14 | The raw data of sample-16 | 1 | Other Type of Proteomic Data | 1.64 GB | raw | 0 | |
| OMIX004444-15 | The raw data of sample-18 | 1 | Other Type of Proteomic Data | 1.61 GB | raw | 0 | |
| OMIX004444-16 | The raw data of sample-19 | 1 | Other Type of Proteomic Data | 838.44 MB | raw | 0 | |
| OMIX004444-17 | The raw data of sample-20 | 1 | Other Type of Proteomic Data | 18.29 MB | raw | 0 |