METTL3-mediated LINC00475 alternative splicing promotes mitochondrial fission in glioblastoma
| Title | METTL3-mediated LINC00475 alternative splicing promotes mitochondrial fission in glioblastoma |
|---|---|
| Description | This project intends to use MeRIP, Pulldown-IP and other technologies in glioma cells and animal models to determine the binding sites of LINC00475 and HNRNPH1, to reveal the mechanism of METTL3-mediated LINC00475 splicing promoting mitochondrial fission by inhibiting MIF, and to clarify the clinical significance of the splicing variant 206 by analyzing the clinical samples and data. This project will reveal a new mechanism of mitochondrial fission in glioma and provide new ideas for glioma therapy. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA017574 |
| Release Date | 2024-03-03 |
| Submitter | Xiao ping Liu (liu_xiaoping@gwcmc.org) |
| Organization | Guangzhou Women and Children's Medical Center |
| Submission Date | 2023-07-04 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004463-01 | Protein profile data-2 | 1 | Proteomic Data by Mass Spectrometry (MS) | 637.78 MB | raw | 0 | |
| OMIX004463-02 | Protein profile data-1 | 1 | Proteomic Data by Mass Spectrometry (MS) | 622.72 MB | raw | 0 | |
| OMIX004463-03 | Protein profile data-3 | 1 | Proteomic Data by Mass Spectrometry (MS) | 622.86 MB | raw | 0 | |
| OMIX004463-04 | Protein profile data-4 | 1 | Proteomic Data by Mass Spectrometry (MS) | 691.52 MB | raw | 0 | |
| OMIX004463-05 | Protein profile data-5 | 1 | Proteomic Data by Mass Spectrometry (MS) | 652.36 MB | raw | 0 | |
| OMIX004463-06 | Protein profile data-6 | 1 | Proteomic Data by Mass Spectrometry (MS) | 601.97 MB | raw | 0 |