Analysis of metabolic characteristics and metabolic fragility in acute lymphoblastic leukemia
| Title | Analysis of metabolic characteristics and metabolic fragility in acute lymphoblastic leukemia |
|---|---|
| Description | Metabolic reprogramming is a hallmark and therapeutic target in cancer, as cancer cells accumulate metabolic changes to meet biosynthetic and energy demands, sustaining rapid proliferation while generating metabolic heterogeneity. Heterogeneous metabolic preferences and dependencies exist among different cancer types and even within cancer cells of the same tissue. Cancer cells acquire metabolic adaptability by responding to various endogenous and exogenous signals, some of which promote malignant cell growth and render them vulnerable to inhibition by key pathway inhibitors. To explore the metabolic features of acute B-cell lymphoblastic leukemia (B-ALL), we collected bone marrow samples from newly diagnosed patients in the PDT-ALL-2016 cohort at Southern Hospital from 2016-2020 for transcriptome sequencing (n=91) and untargeted metabolomics profiling (n=69), in addition to conducting transcriptome sequencing on two B-ALL cell lines (BALL-1 and HAL-01). |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA018245 |
| Release Date | 2023-07-17 |
| Submitter | Hongsheng Zhou (zhs1@i.smu.edu.cn) |
| Organization | Nanfang Hospital, Southern Medical University |
| Submission Date | 2023-07-16 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004528-01 | The raw metabolomics positive data of 42 samples | 42 | Metabolome Data by Mass Spectrometry (MS) | 5.57 GB | zip | 0 | |
| OMIX004528-02 | The raw metabolomics positive data of 27 samples | 27 | Metabolome Data by Mass Spectrometry (MS) | 3.57 GB | zip | 0 | |
| OMIX004528-03 | The raw metabolomics negative data of all samples | 69 | Metabolome Data by Mass Spectrometry (MS) | 7.36 GB | zip | 0 |