OMIX004542

1Summary
Title Tryptophan Metabolite Norharman Secreted by Cultivated Lactobacillus Attenuates Acute Pancreatitis as an Antagonist of Histone Deacetylases
Description Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites, regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial metabolites modulate the innate immune system in AP aggravation. lipid metabolomics further confirmed the imbalance of lipid metabolism in macrophages after Rftn1 knockdown and norharman treatment.
Organism Mus musculus
Data Type Lipidome Data by Mass Spectrometry (MS)
Data Accessibility Open-access
BioProject PRJCA018456
Release Date 2023-07-19
Submitter Qi Zhou (zhouqi94711@163.com)
Organization Dalian Medical University
Submission Date 2023-07-19
2Files & Download

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File ID File Title Number/Samples File Type File Size File Suffix Download
OMIX004542-01 upload 42 Lipidome Data by Mass Spectrometry (MS) 9.3 MB zip
3Relevant Publications
Paper Title Journal Name Publish Time Accession Citing Type
Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases BMC Medicine 2023-08 OMIX004542 OMIX004546 OMIX004547 Deposit

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