Tryptophan Metabolite Norharman Secreted by Cultivated Lactobacillus Attenuates Acute Pancreatitis as an Antagonist of Histone Deacetylases
| Title | Tryptophan Metabolite Norharman Secreted by Cultivated Lactobacillus Attenuates Acute Pancreatitis as an Antagonist of Histone Deacetylases |
|---|---|
| Description | Patients with acute pancreatitis (AP) exhibit specific phenotypes of gut microbiota associated with severity. Gut microbiota and host interact primarily through metabolites, regrettably, little is known about their roles in AP biological networks. This study examines how enterobacterial metabolites modulate the innate immune system in AP aggravation. lipid metabolomics further confirmed the imbalance of lipid metabolism in macrophages after Rftn1 knockdown and norharman treatment. |
| Organism | Mus musculus |
| Data Type | Lipidome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA018456 |
| Release Date | 2023-07-19 |
| Submitter | Qi Zhou (zhouqi94711@163.com) |
| Organization | Dalian Medical University |
| Submission Date | 2023-07-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX004542-01 | upload | 42 | Lipidome Data by Mass Spectrometry (MS) | 9.3 MB | zip | 0 |