Exploring molecular profiles of osteogenically differentiated aortic valvular interstitial cells
| Title | Exploring molecular profiles of osteogenically differentiated aortic valvular interstitial cells |
|---|---|
| Description | Aortic valve calcifications are often associated with calcium deposition and tissue mineralization, resulting in stiffness and dysfunction. To better understand the diversity of molecular and cellular processes for calcification in valve structures, we isolated human aortic valve interstitial cells (AVICs) and exposed them to calcification stimulation. RNA-seq revealed that in response to calcified stimuli, AVIC activates a robust ossification program, although the signaling pathways, cellular processes, and osteogenesis-related markers involved are diverse. In conclusion, this study provides a wealth of information suggesting that the pathogenesis of aortic valve calcification may be much more than previously understood. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA020676 |
| Release Date | 2024-01-01 |
| Submitter | Jinyong Chen (chen_jinyong@zju.edu.cn) |
| Organization | The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date | 2023-10-21 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005122-01 | RNA-seq of osteogenically differentiated aortic valve interstitial cells | 6 | Expression Profiling by NGS | 1.3 MB | txt | 0 |