Cellular landscapes of osteogenically differentiated valvular interstitial cells stimulated with XCT790-loaded nanoparticles
| Title | Cellular landscapes of osteogenically differentiated valvular interstitial cells stimulated with XCT790-loaded nanoparticles |
|---|---|
| Description | The pathogenesis of calcific aortic valve disease (CAVD) is unknown. XCT790 is a specific inhibitor of estrogen-associated receptor alpha (ERR-alpha) that inhibits valve calcification in mouse models. Here, we designed a nanocarrier targeting osteoblast-differentiated valve interstitial cells (VICs) for targeted delivery of XCT790 to the calcified area. We stimulated osteogenic differentiated VICs with this targeting nanoparticle, and performed RNA-seq to assess transcriptional alterations of VICs and explore specific mechanisms. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA020678 |
| Release Date | 2024-01-01 |
| Submitter | Jinyong Chen (chen_jinyong@zju.edu.cn) |
| Organization | The Second Affiliated Hospital, Zhejiang University School of Medicine |
| Submission Date | 2023-10-21 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005123-01 | RNA-seq of osteogenically differentiated valvular interstitial cells stimulated with XCT790-loaded nanoparticles | 12 | Expression Profiling by NGS | 6.3 MB | txt | 0 |