| Title | Integrated single-cell transcriptomics and proteomics reveal dihydroartemisinin regulates the MMPs mediated cellular microenvironment to alleviate rheumatoid arthritis |
|---|---|
| Description | This study aims to investigate the pharmacodynamic mechanism of DHA against RA by means of a combination of single-cell RNA sequencing (RNA-Seq), proteomics, and transcriptomics both in vivo and in vitro. In our results, DHA effectively reduced the degree of redness, swelling, and pain in RA rats, and significantly changed the synovial tissue microenvironment under the pathological state. Within this microenvironment, fibroblasts, macrophages, and B cells were the major affected cell types, primarily through DHA targeting the extracellular matrix (ECM) structural constituent signaling pathway. |
| Organism | Mus |
| Data Type | Expression Profiling |
| Data Accessibility | Open-access |
| BioProject | PRJCA022190 |
| Release Date | 2024-12-07 |
| Submitter | yunmeng bai (2856450699@qq.com) |
| Organization | Shenzhen People's Hospital |
| Submission Date | 2023-12-19 |
HTTP download speed may be slow. It is highly recommended that you download the dataset using a dedicated FTP tool (such as FileZilla Client).
| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download |
|---|---|---|---|---|---|---|
| OMIX005405-02 | Control1 | 3 | Expression Profiling | 29.1 MB | zip | |
| OMIX005405-03 | Control2 | 3 | Expression Profiling | 23.8 MB | zip | |
| OMIX005405-04 | Model 1 | 3 | Expression Profiling | 15.5 MB | zip | |
| OMIX005405-05 | Model 2 | 3 | Expression Profiling | 12.9 MB | zip | |
| OMIX005405-06 | ART 1 | 3 | Expression Profiling | 12.9 MB | zip | |
| OMIX005405-07 | ART 2 | 3 | Expression Profiling | 11.5 MB | zip |
| Paper Title | Journal Name | Publish Time | Accession | Citing Type |
|---|---|---|---|---|
| Dihydroartemisinin regulated the MMPs mediated cellular microenvironment to alleviate rheumatoid arthritis | Research | 2024-09 | OMIX005405 | Deposit |