Urine metabolomics phenotyping in mild cognitive impairment and Alzheimer's disease
| Title | Urine metabolomics phenotyping in mild cognitive impairment and Alzheimer's disease |
|---|---|
| Description | Alzheimer's disease is a prevalent disease with a heavy global burden and is suggested to be a metabolic disease in the brain in recent years. The metabolome is considered to be the most promising phenotype which reflects changes in genetic, transcript, and protein profiles as well as environmental effects. Aiming to obtain a comprehensive understanding and convenient diagnosis of MCI and AD from another perspective, researchers are working on AD metabolomics. Urine is more convenient which could reflect the change of disease at an earlier stage. Thus, we conducted a cross-sectional study to investigate urine metabolomics during AD continuum. We enrolled participants from China-Japan Friendship Hospital from April 2022 to November 2022, collected urine samples and conducted an LC-MS/MS analysis. Fifty-seven AD patients, 43 MCI patients and 62 CN subjects were enrolled. A total of 2140 metabolites were identified. |
| Organism | Homo sapiens |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA022206 |
| Release Date | 2023-12-20 |
| Submitter | Yuye Wang (pumcwyy@126.com) |
| Organization | China-Japan Friendship Hospital |
| Submission Date | 2023-12-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005414-01 | POS_QC | 21 | Metabolome Data by Mass Spectrometry (MS) | 3.07 GB | zip | 0 | |
| OMIX005414-02 | POS_CP3 | 43 | Metabolome Data by Mass Spectrometry (MS) | 6.22 GB | zip | 0 | |
| OMIX005414-03 | POS_CP2 | 62 | Metabolome Data by Mass Spectrometry (MS) | 8.99 GB | zip | 0 | |
| OMIX005414-04 | POS_CP1 | 57 | Metabolome Data by Mass Spectrometry (MS) | 8.2 GB | zip | 0 | |
| OMIX005414-05 | NEG_QC | 21 | Metabolome Data by Mass Spectrometry (MS) | 2.63 GB | zip | 0 | |
| OMIX005414-06 | NEG_CN3 | 43 | Metabolome Data by Mass Spectrometry (MS) | 5.3 GB | zip | 0 | |
| OMIX005414-07 | NEG_CN2 | 62 | Metabolome Data by Mass Spectrometry (MS) | 7.62 GB | zip | 0 | |
| OMIX005414-08 | NEG_CN1 | 57 | Metabolome Data by Mass Spectrometry (MS) | 6.99 GB | zip | 0 | |
| OMIX005414-09 | IDnumber | 1 | Metabolome Data by Mass Spectrometry (MS) | 15.97 KB | xlsx | 0 |