Several bacterial SUPs metabolome data
| Title | Several bacterial SUPs metabolome data |
|---|---|
| Description | Here, we demonstrate that an understudied murine commensal bacterium, Dubosiella newyorkensis, and its human homologue Clostridium innocuum, have a probiotic immunomodulatory effect on dextran sulfate sodium-induced colitis using conventional, antibiotic-treated and germ-free mouse models. We identify an important role for the D. newyorkensis in rebalancing Treg/Th17 responses and ameliorating mucosal barrier injury by producing short-chain fatty acids, especially propionate and L-Lysine (Lys). We further show that Lys induces the immune tolerance ability of dendritic cells (DCs) by enhancing Trp catabolism towards the kynurenine (Kyn) pathway through activation of the metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in an aryl hydrocarbon receptor (AhR)-dependent manner. |
| Organism | Bacteria |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA023021 |
| Release Date | 2024-01-22 |
| Submitter | Jinxin Meng (mengjx855@163.com) |
| Organization | College of Animal Sciences, Zhejiang University |
| Submission Date | 2024-01-20 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005712-01 | akk.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 751.1 KB | zip | 0 | |
| OMIX005712-02 | akk_control.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 756.6 KB | zip | 0 | |
| OMIX005712-03 | dub1.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 760.9 KB | zip | 0 | |
| OMIX005712-04 | dub2.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 759.5 KB | zip | 0 | |
| OMIX005712-05 | dub3.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 758.1 KB | zip | 0 | |
| OMIX005712-06 | dub_control.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 756.9 KB | zip | 0 | |
| OMIX005712-07 | ef.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 747.3 KB | zip | 0 | |
| OMIX005712-08 | ef_control.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 747.1 KB | zip | 0 | |
| OMIX005712-09 | QC1.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 754.4 KB | zip | 0 | |
| OMIX005712-10 | QC2.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 757.9 KB | zip | 0 | |
| OMIX005712-11 | QC3.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 757.7 KB | zip | 0 | |
| OMIX005712-12 | QC4.zip | 1 | Metabolome Data by Mass Spectrometry (MS) | 754.5 KB | zip | 0 |