Multiomics depicting the immunometabolism landscape of steatotic livers undergoing bariatric surgery and diet intervention
| Title | Multiomics depicting the immunometabolism landscape of steatotic livers undergoing bariatric surgery and diet intervention |
|---|---|
| Description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disease worldwide that encompasses a spectrum of steatosis, inflammation, and fibrosis. Evidence suggests that weight loss approaches such as dietary intervention (DI) and bariatric surgery (BS) can lead to remission of hepatic steatosis and inflammation. However, it remains unclear about the effects of weight loss on the hepatic immune mechanisms in MASLD. Therefore, this study aims to elucidate the intricate immunometabolic landscape of steatotic livers following DI and BS by employinh the sleeve gastrectomy (a typical BS procedure) and comparable food intake after sham surgery in a rat model of MASLD. Single-cell (sc) and single-nuclei (sn) transcriptome analysis together with spatial metabolomics and immunohistochemistry were utilized to depict immunometabolic landscape. |
| Organism | Rodentia |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA023404 |
| Release Date | 2024-05-30 |
| Submitter | Hanyang Liu (brandenliu@live.com) |
| Organization | The Affiliated Changzhou Second People's Hospital of Nanjing Medical University |
| Submission Date | 2024-02-02 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005793-01 | Spatial metabolomics_Rat liver | 1 | Metabolome Data by Mass Spectrometry (MS) | 37.3 MB | zip | 0 |