Unveiling the Immune Cell Lineage Mechanisms in COVID-19-Induced Bronchoalveolar Dysfunction
| Title | Unveiling the Immune Cell Lineage Mechanisms in COVID-19-Induced Bronchoalveolar Dysfunction |
|---|---|
| Description | This study utilized the 10x Genomics single-cell RNA sequencing method to analyze changes in immune cell lineages in the bronchoalveolar lavage fluid (BALF) of three severe COVID-19 patients. The research revealed a significant increase in the activation of specific immune cell lineages in COVID-19 patients compared to healthy controls, notably monocytes/neutrophils and macrophages. Furthermore, our study found that the highly activated monocytes and neutrophils, rather than macrophages, were the source of the exacerbated immune response characterized by increased IL1β. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA023917 |
| Release Date | 2024-07-01 |
| Submitter | Jiekai Chen (chen_jiekai@gibh.ac.cn) |
| Organization | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission Date | 2024-03-04 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005927-01 | Human bronchoalveolar lavage fluid single-cell transcriptome counts data (sample 1) | 1 | Expression Profiling by NGS | 782.3 KB | zip | 0 | |
| OMIX005927-02 | Human bronchoalveolar lavage fluid single-cell transcriptome counts data (sample 2) | 1 | Expression Profiling by NGS | 986.2 KB | zip | 0 | |
| OMIX005927-03 | Human bronchoalveolar lavage fluid single-cell transcriptome counts (sample 3) | 1 | Expression Profiling by NGS | 750.5 KB | zip | 0 |