Vitronectin enhances hematopoiesis of human pluripotent stem cells
| Title | Vitronectin enhances hematopoiesis of human pluripotent stem cells |
|---|---|
| Description | VTN and MTG are routinely used for hPSC culture. To investigate their roles in hematopoiesis, we compared the molecular changes between VTN and MTG.A transcriptome analysis was applied after 6 days of hematopoietic differentiation from H1-ESC. The genes in VTN-cultured cells were strongly enriched for the GO terms related to hematopoietic differentiation, including SPN, GATA2, SPI1, GFI1B and KLF1, and were significantly upregulated. Downregulated genes in VTN-cultured cells were related to neurogenesis and were mainly enriched for axon development. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA024065 |
| Release Date | 2024-07-01 |
| Submitter | Jiekai Chen (chen_jiekai@gibh.ac.cn) |
| Organization | Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
| Submission Date | 2024-03-05 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX005933-01 | MTG&VTN Expression Profiling | 1 | Expression Profiling by NGS | 2.6 MB | zip | 0 |