The active extra X chromosome drives germ cell aplasia in klinefelter syndrome fetuses
| Title | The active extra X chromosome drives germ cell aplasia in klinefelter syndrome fetuses |
|---|---|
| Description | The primary pathological alteration in Klinefelter syndrome (KS) is germ cell loss. The alterations prior to loss and the molecular events in germ cells remain largely unknown. Through single-cell RNA sequencing of the gonads of KS and normal male fetuses, the phenotypes of KS fetal gonads and the molecular mechanisms were comprehensively investigated. |
| Organism | Homo sapiens |
| Data Type | Expression Profiling by NGS |
| Data Accessibility | Open-access |
| BioProject | PRJCA012795 |
| Release Date | 2024-06-14 |
| Submitter | Liying Yan (yanliyingkind@aliyun.com) |
| Organization | Peking University Third Hospital |
| Submission Date | 2024-04-07 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX006160-03 | counts_from_10x.csv | 9 | Expression Profiling by NGS | 2.64 GB | csv | 0 | |
| OMIX006160-04 | metadata_from_10x.csv | 9 | Expression Profiling by NGS | 3.98 MB | csv | 0 | |
| OMIX006160-05 | Male_and_KS_TPM_matrix_from_Smart_seq2.csv | 19 | Expression Profiling by NGS | 56.97 MB | csv | 0 | |
| OMIX006160-06 | Male_and_KS_metadata_from_Smart_seq2.xls | 19 | Expression Profiling by NGS | 304.5 KB | xls | 0 | |
| OMIX006160-07 | Female_TPM_matrix_from_Smart_seq2.csv | 16 | Expression Profiling by NGS | 52.82 MB | csv | 0 | |
| OMIX006160-08 | Female_metadata_from_Smart_seq2.xls | 16 | Expression Profiling by NGS | 95.5 KB | xls | 0 | |
| OMIX006160-09 | SS200000513TL_C5.tissue.gem | 1 | Expression Profiling by NGS | 558.56 MB | gem | 0 | |
| OMIX006160-10 | SS200000513TL_C6.tissue.gem | 1 | Expression Profiling by NGS | 474.01 MB | gem | 0 | |
| OMIX006160-11 | D03058F1.tissue.gem | 1 | Expression Profiling by NGS | 1.19 GB | gem | 0 | |
| OMIX006160-12 | D03058E6.tissue.gem | 1 | Expression Profiling by NGS | 888.51 MB | gem | 0 | |
| OMIX006160-14 | methylation_data | 154 | Expression Profiling by NGS | 8.39 GB | tar.gz | 0 |